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Gene: ZNF730 |
Gene summary for ZNF730 |
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Gene information | Species | Human | Gene symbol | ZNF730 | Gene ID | 100129543 |
Gene name | zinc finger protein 730 | |
Gene Alias | ZNF730 | |
Cytomap | 19p12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q6ZMV8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
100129543 | ZNF730 | HTA11_4255_2000001011 | Human | Colorectum | SER | 8.80e-11 | 7.52e-01 | 0.0446 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF730 | insertion | Frame_Shift_Ins | novel | c.886_887insTAAAG | p.Ser296LeufsTer67 | p.S296Lfs*67 | Q6ZMV8 | protein_coding | TCGA-C9-A47Z-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
ZNF730 | SNV | Missense_Mutation | rs765070865 | c.1118G>A | p.Cys373Tyr | p.C373Y | Q6ZMV8 | protein_coding | deleterious(0.01) | probably_damaging(0.987) | TCGA-ZG-A9L0-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | SD |
ZNF730 | SNV | Missense_Mutation | novel | c.832N>A | p.His278Asn | p.H278N | Q6ZMV8 | protein_coding | deleterious(0) | benign(0.317) | TCGA-B7-5816-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF730 | SNV | Missense_Mutation | novel | c.29N>T | p.Ala10Val | p.A10V | Q6ZMV8 | protein_coding | tolerated(0.07) | possibly_damaging(0.469) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF730 | SNV | Missense_Mutation | novel | c.236C>T | p.Ser79Phe | p.S79F | Q6ZMV8 | protein_coding | tolerated(0.05) | benign(0.08) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
ZNF730 | SNV | Missense_Mutation | novel | c.1378G>T | p.Ala460Ser | p.A460S | Q6ZMV8 | protein_coding | deleterious(0.04) | probably_damaging(0.94) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
ZNF730 | SNV | Missense_Mutation | novel | c.1121N>A | p.Gly374Asp | p.G374D | Q6ZMV8 | protein_coding | deleterious(0.04) | possibly_damaging(0.53) | TCGA-BR-A4PE-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF730 | SNV | Missense_Mutation | novel | c.1076N>C | p.Lys359Thr | p.K359T | Q6ZMV8 | protein_coding | deleterious(0.01) | possibly_damaging(0.857) | TCGA-D7-6518-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
ZNF730 | SNV | Missense_Mutation | c.1496N>C | p.Lys499Thr | p.K499T | Q6ZMV8 | protein_coding | deleterious(0.01) | possibly_damaging(0.849) | TCGA-D7-A4YY-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | SD | |
ZNF730 | SNV | Missense_Mutation | c.146A>T | p.Lys49Met | p.K49M | Q6ZMV8 | protein_coding | deleterious(0.01) | possibly_damaging(0.661) | TCGA-HF-7134-01 | Stomach | stomach adenocarcinoma | Male | Unknown | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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