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Gene: ZNF574 |
Gene summary for ZNF574 |
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Gene information | Species | Human | Gene symbol | ZNF574 | Gene ID | 64763 |
Gene name | zinc finger protein 574 | |
Gene Alias | FP972 | |
Cytomap | 19q13.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A0C4DFM2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64763 | ZNF574 | LZE4T | Human | Esophagus | ESCC | 5.53e-04 | 1.76e-01 | 0.0811 |
64763 | ZNF574 | LZE7T | Human | Esophagus | ESCC | 2.88e-02 | 1.64e-01 | 0.0667 |
64763 | ZNF574 | LZE8T | Human | Esophagus | ESCC | 4.06e-05 | 1.26e-01 | 0.067 |
64763 | ZNF574 | LZE24T | Human | Esophagus | ESCC | 3.77e-11 | 3.53e-01 | 0.0596 |
64763 | ZNF574 | LZE21T | Human | Esophagus | ESCC | 2.21e-03 | 2.36e-01 | 0.0655 |
64763 | ZNF574 | P1T-E | Human | Esophagus | ESCC | 1.12e-06 | 1.92e-01 | 0.0875 |
64763 | ZNF574 | P2T-E | Human | Esophagus | ESCC | 1.01e-19 | 3.43e-01 | 0.1177 |
64763 | ZNF574 | P4T-E | Human | Esophagus | ESCC | 2.09e-09 | 1.62e-01 | 0.1323 |
64763 | ZNF574 | P5T-E | Human | Esophagus | ESCC | 2.92e-17 | 1.73e-01 | 0.1327 |
64763 | ZNF574 | P8T-E | Human | Esophagus | ESCC | 3.43e-20 | 3.10e-01 | 0.0889 |
64763 | ZNF574 | P10T-E | Human | Esophagus | ESCC | 5.76e-15 | 2.03e-01 | 0.116 |
64763 | ZNF574 | P11T-E | Human | Esophagus | ESCC | 1.20e-16 | 7.12e-01 | 0.1426 |
64763 | ZNF574 | P12T-E | Human | Esophagus | ESCC | 1.61e-20 | 3.82e-01 | 0.1122 |
64763 | ZNF574 | P15T-E | Human | Esophagus | ESCC | 6.84e-20 | 4.18e-01 | 0.1149 |
64763 | ZNF574 | P16T-E | Human | Esophagus | ESCC | 1.96e-15 | 2.51e-01 | 0.1153 |
64763 | ZNF574 | P20T-E | Human | Esophagus | ESCC | 3.43e-19 | 4.37e-01 | 0.1124 |
64763 | ZNF574 | P21T-E | Human | Esophagus | ESCC | 6.65e-10 | 2.56e-02 | 0.1617 |
64763 | ZNF574 | P22T-E | Human | Esophagus | ESCC | 3.69e-14 | 1.91e-01 | 0.1236 |
64763 | ZNF574 | P23T-E | Human | Esophagus | ESCC | 2.91e-16 | 4.75e-01 | 0.108 |
64763 | ZNF574 | P24T-E | Human | Esophagus | ESCC | 4.33e-14 | 1.54e-01 | 0.1287 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF574 | deletion | Frame_Shift_Del | novel | c.939delN | p.Gln314SerfsTer144 | p.Q314Sfs*144 | protein_coding | TCGA-56-7221-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
ZNF574 | SNV | Missense_Mutation | c.1376N>T | p.Cys459Phe | p.C459F | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CN-4728-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | vectibix | SD | ||
ZNF574 | SNV | Missense_Mutation | novel | c.1788N>C | p.Lys596Asn | p.K596N | protein_coding | deleterious(0.01) | probably_damaging(0.983) | TCGA-CR-6484-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD | |
ZNF574 | SNV | Missense_Mutation | rs369881574 | c.2180N>A | p.Arg727His | p.R727H | protein_coding | tolerated(0.37) | probably_damaging(0.968) | TCGA-CH-5769-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD | |
ZNF574 | SNV | Missense_Mutation | rs376269644 | c.1105C>T | p.Arg369Cys | p.R369C | protein_coding | deleterious(0.02) | probably_damaging(0.977) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD | |
ZNF574 | SNV | Missense_Mutation | novel | c.1531N>T | p.Pro511Ser | p.P511S | protein_coding | deleterious(0.03) | benign(0.042) | TCGA-ZG-A9LZ-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | SD | |
ZNF574 | SNV | Missense_Mutation | rs369467558 | c.2711N>A | p.Arg904His | p.R904H | protein_coding | tolerated(0.07) | possibly_damaging(0.766) | TCGA-BR-4256-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF574 | SNV | Missense_Mutation | c.1951N>G | p.Thr651Ala | p.T651A | protein_coding | tolerated(0.06) | benign(0.143) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF574 | SNV | Missense_Mutation | novel | c.2156N>A | p.Val719Asp | p.V719D | protein_coding | tolerated(0.62) | benign(0) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF574 | SNV | Missense_Mutation | c.2522C>T | p.Thr841Met | p.T841M | protein_coding | deleterious(0.01) | probably_damaging(0.989) | TCGA-BR-7901-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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