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Gene: ZNF518A |
Gene summary for ZNF518A |
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Gene information | Species | Human | Gene symbol | ZNF518A | Gene ID | 9849 |
Gene name | zinc finger protein 518A | |
Gene Alias | ZNF518 | |
Cytomap | 10q24.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q6AHZ1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9849 | ZNF518A | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.11e-11 | -4.38e-01 | 0.0155 |
9849 | ZNF518A | HTA11_696_2000001011 | Human | Colorectum | AD | 7.02e-03 | -2.74e-01 | -0.1464 |
9849 | ZNF518A | HTA11_7862_2000001011 | Human | Colorectum | AD | 3.25e-02 | -4.76e-01 | -0.0179 |
9849 | ZNF518A | HTA11_866_3004761011 | Human | Colorectum | AD | 2.78e-03 | -3.07e-01 | 0.096 |
9849 | ZNF518A | HTA11_8622_2000001021 | Human | Colorectum | SER | 8.68e-04 | -4.64e-01 | 0.0528 |
9849 | ZNF518A | HTA11_10711_2000001011 | Human | Colorectum | AD | 4.55e-03 | -4.20e-01 | 0.0338 |
9849 | ZNF518A | HTA11_7696_3000711011 | Human | Colorectum | AD | 9.54e-07 | -3.68e-01 | 0.0674 |
9849 | ZNF518A | HTA11_99999965104_69814 | Human | Colorectum | MSS | 7.50e-04 | 5.94e-01 | 0.281 |
9849 | ZNF518A | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.63e-03 | -2.73e-01 | 0.3859 |
9849 | ZNF518A | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.87e-06 | -5.94e-01 | 0.2585 |
9849 | ZNF518A | HTA11_99999974143_84620 | Human | Colorectum | MSS | 8.28e-14 | -4.70e-01 | 0.3005 |
9849 | ZNF518A | A001-C-207 | Human | Colorectum | FAP | 9.49e-03 | -1.05e-01 | 0.1278 |
9849 | ZNF518A | A015-C-203 | Human | Colorectum | FAP | 1.54e-33 | -2.13e-01 | -0.1294 |
9849 | ZNF518A | A015-C-204 | Human | Colorectum | FAP | 6.92e-04 | 3.49e-02 | -0.0228 |
9849 | ZNF518A | A014-C-040 | Human | Colorectum | FAP | 6.81e-05 | -6.20e-02 | -0.1184 |
9849 | ZNF518A | A002-C-201 | Human | Colorectum | FAP | 9.12e-13 | -2.04e-01 | 0.0324 |
9849 | ZNF518A | A002-C-203 | Human | Colorectum | FAP | 5.51e-03 | 7.30e-02 | 0.2786 |
9849 | ZNF518A | A001-C-119 | Human | Colorectum | FAP | 7.41e-12 | -4.31e-01 | -0.1557 |
9849 | ZNF518A | A001-C-108 | Human | Colorectum | FAP | 2.77e-19 | 6.34e-02 | -0.0272 |
9849 | ZNF518A | A002-C-205 | Human | Colorectum | FAP | 5.03e-24 | -4.09e-01 | -0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006325 | Colorectum | AD | chromatin organization | 119/3918 | 409/18723 | 4.85e-05 | 8.33e-04 | 119 |
GO:00063251 | Colorectum | SER | chromatin organization | 89/2897 | 409/18723 | 4.15e-04 | 6.17e-03 | 89 |
GO:00063252 | Colorectum | MSS | chromatin organization | 107/3467 | 409/18723 | 7.22e-05 | 1.21e-03 | 107 |
GO:00063253 | Colorectum | FAP | chromatin organization | 84/2622 | 409/18723 | 1.62e-04 | 2.47e-03 | 84 |
GO:00063254 | Colorectum | CRC | chromatin organization | 74/2078 | 409/18723 | 1.48e-05 | 4.61e-04 | 74 |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:00063255 | Liver | NAFLD | chromatin organization | 64/1882 | 409/18723 | 2.31e-04 | 3.89e-03 | 64 |
GO:000632511 | Liver | HCC | chromatin organization | 206/7958 | 409/18723 | 7.23e-04 | 4.41e-03 | 206 |
GO:000632520 | Thyroid | PTC | chromatin organization | 183/5968 | 409/18723 | 2.55e-08 | 5.70e-07 | 183 |
GO:0006325110 | Thyroid | ATC | chromatin organization | 189/6293 | 409/18723 | 6.40e-08 | 1.13e-06 | 189 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF518A | SNV | Missense_Mutation | novel | c.4367N>C | p.Arg1456Thr | p.R1456T | Q6AHZ1 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-B5-A11R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
ZNF518A | SNV | Missense_Mutation | novel | c.356N>C | p.Phe119Ser | p.F119S | Q6AHZ1 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF518A | SNV | Missense_Mutation | rs782765056 | c.521G>A | p.Ser174Asn | p.S174N | Q6AHZ1 | protein_coding | tolerated(0.07) | benign(0.012) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF518A | SNV | Missense_Mutation | rs782501732 | c.1328C>T | p.Thr443Met | p.T443M | Q6AHZ1 | protein_coding | deleterious(0) | benign(0.082) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF518A | SNV | Missense_Mutation | novel | c.861A>C | p.Glu287Asp | p.E287D | Q6AHZ1 | protein_coding | tolerated(1) | benign(0.037) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF518A | SNV | Missense_Mutation | novel | c.2292N>G | p.Ile764Met | p.I764M | Q6AHZ1 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-D1-A3DG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ZNF518A | SNV | Missense_Mutation | novel | c.842N>C | p.Val281Ala | p.V281A | Q6AHZ1 | protein_coding | deleterious(0) | benign(0.339) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
ZNF518A | SNV | Missense_Mutation | novel | c.2317N>A | p.Gln773Lys | p.Q773K | Q6AHZ1 | protein_coding | tolerated(0.34) | benign(0) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
ZNF518A | SNV | Missense_Mutation | novel | c.290C>T | p.Thr97Ile | p.T97I | Q6AHZ1 | protein_coding | tolerated(0.41) | benign(0) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
ZNF518A | SNV | Missense_Mutation | novel | c.4028G>T | p.Arg1343Ile | p.R1343I | Q6AHZ1 | protein_coding | deleterious(0) | possibly_damaging(0.879) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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