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Gene: ZNF407 |
Gene summary for ZNF407 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ZNF407 | Gene ID | 55628 |
Gene name | zinc finger protein 407 | |
Gene Alias | ZNF407 | |
Cytomap | 18q22.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9C0G0 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55628 | ZNF407 | CCI_1 | Human | Cervix | CC | 1.40e-09 | 9.92e-01 | 0.528 |
55628 | ZNF407 | CCI_2 | Human | Cervix | CC | 8.28e-08 | 8.20e-01 | 0.5249 |
55628 | ZNF407 | CCI_3 | Human | Cervix | CC | 8.04e-16 | 9.82e-01 | 0.516 |
55628 | ZNF407 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.47e-22 | -7.22e-01 | 0.0155 |
55628 | ZNF407 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.28e-04 | -4.89e-01 | -0.1808 |
55628 | ZNF407 | HTA11_1938_2000001011 | Human | Colorectum | AD | 7.81e-05 | -5.10e-01 | -0.0811 |
55628 | ZNF407 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.01e-09 | -7.38e-01 | -0.1207 |
55628 | ZNF407 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.14e-11 | -5.37e-01 | -0.1464 |
55628 | ZNF407 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.42e-12 | -4.91e-01 | -0.1001 |
55628 | ZNF407 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.32e-03 | -3.98e-01 | -0.059 |
55628 | ZNF407 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.27e-02 | -5.38e-01 | -0.0179 |
55628 | ZNF407 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.53e-15 | -6.43e-01 | 0.096 |
55628 | ZNF407 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.18e-02 | -6.55e-01 | 0.0528 |
55628 | ZNF407 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.83e-09 | -6.58e-01 | 0.0338 |
55628 | ZNF407 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.23e-22 | -6.44e-01 | 0.0674 |
55628 | ZNF407 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.62e-03 | -4.95e-01 | 0.0588 |
55628 | ZNF407 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.73e-17 | -5.28e-01 | 0.294 |
55628 | ZNF407 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.20e-15 | -5.89e-01 | 0.3859 |
55628 | ZNF407 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.16e-06 | -7.20e-01 | 0.2585 |
55628 | ZNF407 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.08e-23 | -6.59e-01 | 0.3005 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF407 | SNV | Missense_Mutation | novel | c.5455C>T | p.Arg1819Cys | p.R1819C | Q9C0G0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF407 | SNV | Missense_Mutation | rs199739482 | c.5573C>T | p.Pro1858Leu | p.P1858L | Q9C0G0 | protein_coding | tolerated(0.3) | benign(0.087) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF407 | SNV | Missense_Mutation | novel | c.4949N>G | p.His1650Arg | p.H1650R | Q9C0G0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF407 | SNV | Missense_Mutation | novel | c.6383N>T | p.Ala2128Val | p.A2128V | Q9C0G0 | protein_coding | tolerated(0.12) | benign(0.337) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF407 | SNV | Missense_Mutation | novel | c.4200G>T | p.Lys1400Asn | p.K1400N | Q9C0G0 | protein_coding | deleterious(0.02) | possibly_damaging(0.462) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF407 | SNV | Missense_Mutation | rs781417819 | c.6247N>A | p.Val2083Ile | p.V2083I | Q9C0G0 | protein_coding | deleterious(0.01) | possibly_damaging(0.592) | TCGA-AJ-A23O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF407 | SNV | Missense_Mutation | rs780972850 | c.1519C>T | p.Arg507Cys | p.R507C | Q9C0G0 | protein_coding | tolerated(0.16) | benign(0) | TCGA-AJ-A3BG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
ZNF407 | SNV | Missense_Mutation | novel | c.3682N>A | p.Val1228Ile | p.V1228I | Q9C0G0 | protein_coding | tolerated(0.4) | benign(0) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
ZNF407 | SNV | Missense_Mutation | novel | c.12T>G | p.Ser4Arg | p.S4R | Q9C0G0 | protein_coding | tolerated_low_confidence(0.19) | benign(0) | TCGA-AJ-A3BK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF407 | SNV | Missense_Mutation | novel | c.846N>T | p.Gln282His | p.Q282H | Q9C0G0 | protein_coding | tolerated(0.07) | benign(0.082) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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