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Gene: ZNF329 |
Gene summary for ZNF329 |
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Gene information | Species | Human | Gene symbol | ZNF329 | Gene ID | 79673 |
Gene name | zinc finger protein 329 | |
Gene Alias | ZNF329 | |
Cytomap | 19q13.43 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A024R4Q4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79673 | ZNF329 | HCC1 | Human | Liver | HCC | 1.40e-03 | 2.33e+00 | 0.5336 |
79673 | ZNF329 | HCC2 | Human | Liver | HCC | 1.54e-13 | 2.56e+00 | 0.5341 |
79673 | ZNF329 | HCC5 | Human | Liver | HCC | 9.64e-07 | 6.16e-01 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZNF329 | TRANS | Cervix | HSIL_HPV | AC012593.1,POSTN,HIST1H1A, etc. | 4.63e-02 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF329 | SNV | Missense_Mutation | novel | c.277N>T | p.Ala93Ser | p.A93S | Q86UD4 | protein_coding | tolerated(0.68) | benign(0.007) | TCGA-43-2581-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
ZNF329 | SNV | Missense_Mutation | novel | c.1521N>T | p.Arg507Ser | p.R507S | Q86UD4 | protein_coding | deleterious(0.02) | benign(0.255) | TCGA-56-8305-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF329 | SNV | Missense_Mutation | novel | c.632G>T | p.Cys211Phe | p.C211F | Q86UD4 | protein_coding | deleterious(0.04) | possibly_damaging(0.896) | TCGA-56-8628-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF329 | SNV | Missense_Mutation | rs755020594 | c.1057N>T | p.Arg353Trp | p.R353W | Q86UD4 | protein_coding | deleterious(0.01) | possibly_damaging(0.88) | TCGA-77-A5G3-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF329 | SNV | Missense_Mutation | novel | c.772N>G | p.Pro258Ala | p.P258A | Q86UD4 | protein_coding | deleterious(0) | possibly_damaging(0.78) | TCGA-79-5596-01 | Lung | lung squamous cell carcinoma | Male | Unknown | III/IV | Unknown | Unknown | SD |
ZNF329 | SNV | Missense_Mutation | novel | c.1000N>G | p.Leu334Val | p.L334V | Q86UD4 | protein_coding | tolerated(0.19) | benign(0.251) | TCGA-92-7340-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
ZNF329 | SNV | Missense_Mutation | c.1354G>A | p.Glu452Lys | p.E452K | Q86UD4 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-CN-4723-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF329 | SNV | Missense_Mutation | c.1181N>T | p.Ser394Phe | p.S394F | Q86UD4 | protein_coding | deleterious(0) | possibly_damaging(0.837) | TCGA-CN-4728-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | vectibix | SD | |
ZNF329 | SNV | Missense_Mutation | novel | c.72N>A | p.Phe24Leu | p.F24L | Q86UD4 | protein_coding | tolerated(0.77) | benign(0.075) | TCGA-CN-6010-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
ZNF329 | SNV | Missense_Mutation | rs368309022 | c.1534N>T | p.Arg512Trp | p.R512W | Q86UD4 | protein_coding | deleterious(0) | benign(0.417) | TCGA-CV-7243-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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