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Gene: ZNF182 |
Gene summary for ZNF182 |
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Gene information | Species | Human | Gene symbol | ZNF182 | Gene ID | 7569 |
Gene name | zinc finger protein 182 | |
Gene Alias | HHZ150 | |
Cytomap | Xp11.23 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P17025 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7569 | ZNF182 | HCC1_Meng | Human | Liver | HCC | 1.13e-10 | 6.09e-03 | 0.0246 |
7569 | ZNF182 | HCC1 | Human | Liver | HCC | 4.49e-17 | 4.48e+00 | 0.5336 |
7569 | ZNF182 | HCC2 | Human | Liver | HCC | 5.09e-04 | 2.57e+00 | 0.5341 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF182 | SNV | Missense_Mutation | novel | c.203A>G | p.Gln68Arg | p.Q68R | P17025 | protein_coding | deleterious(0.01) | benign(0) | TCGA-DD-AADB-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF182 | SNV | Missense_Mutation | c.1113N>T | p.Lys371Asn | p.K371N | P17025 | protein_coding | deleterious(0.04) | possibly_damaging(0.531) | TCGA-44-7672-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF182 | SNV | Missense_Mutation | c.617N>G | p.Tyr206Cys | p.Y206C | P17025 | protein_coding | tolerated(0.15) | benign(0.003) | TCGA-78-7147-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF182 | SNV | Missense_Mutation | novel | c.929G>T | p.Arg310Met | p.R310M | P17025 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-L9-A444-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF182 | SNV | Missense_Mutation | rs782204454 | c.1422G>A | p.Met474Ile | p.M474I | P17025 | protein_coding | tolerated(1) | benign(0.009) | TCGA-33-4589-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF182 | SNV | Missense_Mutation | novel | c.1668N>T | p.Gln556His | p.Q556H | P17025 | protein_coding | tolerated(0.16) | benign(0.039) | TCGA-56-8307-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF182 | SNV | Missense_Mutation | rs782543305 | c.481N>A | p.Glu161Lys | p.E161K | P17025 | protein_coding | tolerated(0.22) | benign(0.012) | TCGA-56-8625-01 | Lung | lung squamous cell carcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD |
ZNF182 | SNV | Missense_Mutation | novel | c.1067N>C | p.Ile356Thr | p.I356T | P17025 | protein_coding | tolerated(0.58) | benign(0.009) | TCGA-60-2715-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | docetaxel | PD |
ZNF182 | SNV | Missense_Mutation | novel | c.349C>A | p.Leu117Met | p.L117M | P17025 | protein_coding | tolerated(0.24) | benign(0.052) | TCGA-77-A5G3-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF182 | SNV | Missense_Mutation | novel | c.296N>A | p.Cys99Tyr | p.C99Y | P17025 | protein_coding | tolerated(1) | benign(0) | TCGA-85-A5B5-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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