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Gene: ZFYVE16 |
Gene summary for ZFYVE16 |
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Gene information | Species | Human | Gene symbol | ZFYVE16 | Gene ID | 9765 |
Gene name | zinc finger FYVE-type containing 16 | |
Gene Alias | PPP1R69 | |
Cytomap | 5q14.1 | |
Gene Type | protein-coding | GO ID | GO:0006605 | UniProtAcc | Q7Z3T8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9765 | ZFYVE16 | LZE5T | Human | Esophagus | ESCC | 5.47e-05 | 3.25e-01 | 0.0514 |
9765 | ZFYVE16 | LZE7T | Human | Esophagus | ESCC | 1.78e-02 | 2.11e-01 | 0.0667 |
9765 | ZFYVE16 | LZE8T | Human | Esophagus | ESCC | 2.87e-04 | 1.52e-01 | 0.067 |
9765 | ZFYVE16 | LZE20T | Human | Esophagus | ESCC | 1.29e-03 | 1.38e-01 | 0.0662 |
9765 | ZFYVE16 | LZE24T | Human | Esophagus | ESCC | 4.50e-11 | 2.28e-01 | 0.0596 |
9765 | ZFYVE16 | P1T-E | Human | Esophagus | ESCC | 1.72e-04 | 1.85e-01 | 0.0875 |
9765 | ZFYVE16 | P2T-E | Human | Esophagus | ESCC | 1.83e-19 | 2.79e-01 | 0.1177 |
9765 | ZFYVE16 | P4T-E | Human | Esophagus | ESCC | 4.90e-05 | 1.65e-01 | 0.1323 |
9765 | ZFYVE16 | P8T-E | Human | Esophagus | ESCC | 3.06e-17 | 2.01e-01 | 0.0889 |
9765 | ZFYVE16 | P9T-E | Human | Esophagus | ESCC | 1.10e-10 | 2.15e-01 | 0.1131 |
9765 | ZFYVE16 | P10T-E | Human | Esophagus | ESCC | 1.09e-14 | 1.52e-01 | 0.116 |
9765 | ZFYVE16 | P11T-E | Human | Esophagus | ESCC | 1.41e-02 | 2.42e-01 | 0.1426 |
9765 | ZFYVE16 | P12T-E | Human | Esophagus | ESCC | 1.62e-18 | 3.15e-01 | 0.1122 |
9765 | ZFYVE16 | P15T-E | Human | Esophagus | ESCC | 4.32e-08 | 2.25e-01 | 0.1149 |
9765 | ZFYVE16 | P16T-E | Human | Esophagus | ESCC | 2.33e-09 | 1.64e-01 | 0.1153 |
9765 | ZFYVE16 | P19T-E | Human | Esophagus | ESCC | 2.04e-02 | 3.68e-01 | 0.1662 |
9765 | ZFYVE16 | P20T-E | Human | Esophagus | ESCC | 7.36e-09 | 1.71e-01 | 0.1124 |
9765 | ZFYVE16 | P21T-E | Human | Esophagus | ESCC | 1.48e-13 | 1.86e-01 | 0.1617 |
9765 | ZFYVE16 | P22T-E | Human | Esophagus | ESCC | 6.20e-08 | 1.60e-01 | 0.1236 |
9765 | ZFYVE16 | P23T-E | Human | Esophagus | ESCC | 1.43e-09 | 2.73e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0072594110 | Esophagus | ESCC | establishment of protein localization to organelle | 311/8552 | 422/18723 | 3.02e-32 | 2.13e-29 | 311 |
GO:0006605111 | Esophagus | ESCC | protein targeting | 229/8552 | 314/18723 | 4.93e-23 | 1.01e-20 | 229 |
GO:001605014 | Esophagus | ESCC | vesicle organization | 211/8552 | 300/18723 | 2.85e-18 | 2.87e-16 | 211 |
GO:001619715 | Esophagus | ESCC | endosomal transport | 168/8552 | 230/18723 | 2.28e-17 | 1.93e-15 | 168 |
GO:000703417 | Esophagus | ESCC | vacuolar transport | 119/8552 | 157/18723 | 1.16e-14 | 6.30e-13 | 119 |
GO:00070419 | Esophagus | ESCC | lysosomal transport | 83/8552 | 114/18723 | 3.52e-09 | 7.41e-08 | 83 |
GO:003010018 | Esophagus | ESCC | regulation of endocytosis | 135/8552 | 211/18723 | 5.75e-08 | 1.02e-06 | 135 |
GO:00726659 | Esophagus | ESCC | protein localization to vacuole | 52/8552 | 67/18723 | 9.14e-08 | 1.52e-06 | 52 |
GO:00066238 | Esophagus | ESCC | protein targeting to vacuole | 31/8552 | 37/18723 | 1.95e-06 | 2.26e-05 | 31 |
GO:00726668 | Esophagus | ESCC | establishment of protein localization to vacuole | 37/8552 | 49/18723 | 2.05e-05 | 1.78e-04 | 37 |
GO:00066226 | Esophagus | ESCC | protein targeting to lysosome | 20/8552 | 23/18723 | 4.97e-05 | 3.86e-04 | 20 |
GO:00614626 | Esophagus | ESCC | protein localization to lysosome | 34/8552 | 46/18723 | 9.39e-05 | 6.70e-04 | 34 |
GO:00066233 | Liver | NAFLD | protein targeting to vacuole | 12/1882 | 37/18723 | 1.73e-04 | 3.08e-03 | 12 |
GO:00161975 | Liver | NAFLD | endosomal transport | 41/1882 | 230/18723 | 2.02e-04 | 3.53e-03 | 41 |
GO:00160505 | Liver | NAFLD | vesicle organization | 50/1882 | 300/18723 | 2.42e-04 | 4.06e-03 | 50 |
GO:00726653 | Liver | NAFLD | protein localization to vacuole | 16/1882 | 67/18723 | 7.94e-04 | 9.90e-03 | 16 |
GO:00726663 | Liver | NAFLD | establishment of protein localization to vacuole | 13/1882 | 49/18723 | 8.43e-04 | 1.03e-02 | 13 |
GO:00725947 | Liver | NAFLD | establishment of protein localization to organelle | 62/1882 | 422/18723 | 1.48e-03 | 1.64e-02 | 62 |
GO:00070345 | Liver | NAFLD | vacuolar transport | 28/1882 | 157/18723 | 1.91e-03 | 1.93e-02 | 28 |
GO:00070414 | Liver | NAFLD | lysosomal transport | 22/1882 | 114/18723 | 2.03e-03 | 2.02e-02 | 22 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04144210 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa043507 | Esophagus | ESCC | TGF-beta signaling pathway | 69/4205 | 108/8465 | 1.92e-03 | 5.54e-03 | 2.84e-03 | 69 |
hsa0414437 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0435014 | Esophagus | ESCC | TGF-beta signaling pathway | 69/4205 | 108/8465 | 1.92e-03 | 5.54e-03 | 2.84e-03 | 69 |
hsa0414412 | Liver | Cirrhotic | Endocytosis | 119/2530 | 251/8465 | 2.33e-09 | 4.56e-08 | 2.81e-08 | 119 |
hsa0414413 | Liver | Cirrhotic | Endocytosis | 119/2530 | 251/8465 | 2.33e-09 | 4.56e-08 | 2.81e-08 | 119 |
hsa0414422 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0414432 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZFYVE16 | SNV | Missense_Mutation | c.2687N>A | p.Ser896Tyr | p.S896Y | Q7Z3T8 | protein_coding | deleterious(0) | probably_damaging(0.91) | TCGA-BG-A0MQ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZFYVE16 | SNV | Missense_Mutation | novel | c.3788A>G | p.Tyr1263Cys | p.Y1263C | Q7Z3T8 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZFYVE16 | SNV | Missense_Mutation | novel | c.1540N>T | p.Asp514Tyr | p.D514Y | Q7Z3T8 | protein_coding | deleterious(0) | possibly_damaging(0.459) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZFYVE16 | SNV | Missense_Mutation | rs376948348 | c.3698N>A | p.Arg1233Gln | p.R1233Q | Q7Z3T8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZFYVE16 | SNV | Missense_Mutation | novel | c.634G>A | p.Asp212Asn | p.D212N | Q7Z3T8 | protein_coding | tolerated(0.14) | benign(0.395) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZFYVE16 | SNV | Missense_Mutation | novel | c.635A>G | p.Asp212Gly | p.D212G | Q7Z3T8 | protein_coding | tolerated(0.13) | benign(0.318) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZFYVE16 | SNV | Missense_Mutation | c.2751N>G | p.His917Gln | p.H917Q | Q7Z3T8 | protein_coding | tolerated(0.29) | benign(0.011) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
ZFYVE16 | SNV | Missense_Mutation | c.4082G>A | p.Arg1361Gln | p.R1361Q | Q7Z3T8 | protein_coding | deleterious(0.01) | possibly_damaging(0.862) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZFYVE16 | SNV | Missense_Mutation | c.4127N>C | p.Val1376Ala | p.V1376A | Q7Z3T8 | protein_coding | tolerated(1) | benign(0.02) | TCGA-D1-A15X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZFYVE16 | SNV | Missense_Mutation | c.3638G>A | p.Gly1213Asp | p.G1213D | Q7Z3T8 | protein_coding | tolerated(0.75) | benign(0.012) | TCGA-D1-A17U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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