![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ZFX |
Gene summary for ZFX |
![]() |
Gene information | Species | Human | Gene symbol | ZFX | Gene ID | 7543 |
Gene name | zinc finger protein X-linked | |
Gene Alias | ZNF926 | |
Cytomap | Xp22.11 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A024RC04 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7543 | ZFX | LZE4T | Human | Esophagus | ESCC | 4.98e-09 | 4.44e-01 | 0.0811 |
7543 | ZFX | LZE5T | Human | Esophagus | ESCC | 3.51e-03 | 2.92e-01 | 0.0514 |
7543 | ZFX | LZE20T | Human | Esophagus | ESCC | 5.40e-03 | 1.26e-01 | 0.0662 |
7543 | ZFX | LZE22T | Human | Esophagus | ESCC | 1.12e-03 | 2.65e-01 | 0.068 |
7543 | ZFX | LZE24T | Human | Esophagus | ESCC | 7.86e-06 | 1.14e-01 | 0.0596 |
7543 | ZFX | LZE21T | Human | Esophagus | ESCC | 1.93e-03 | 1.83e-01 | 0.0655 |
7543 | ZFX | LZE6T | Human | Esophagus | ESCC | 6.71e-03 | 1.49e-01 | 0.0845 |
7543 | ZFX | P2T-E | Human | Esophagus | ESCC | 1.35e-34 | 6.54e-01 | 0.1177 |
7543 | ZFX | P4T-E | Human | Esophagus | ESCC | 9.11e-17 | 3.72e-01 | 0.1323 |
7543 | ZFX | P5T-E | Human | Esophagus | ESCC | 4.04e-05 | 9.46e-02 | 0.1327 |
7543 | ZFX | P8T-E | Human | Esophagus | ESCC | 5.66e-17 | 3.70e-01 | 0.0889 |
7543 | ZFX | P9T-E | Human | Esophagus | ESCC | 1.62e-09 | 2.31e-01 | 0.1131 |
7543 | ZFX | P10T-E | Human | Esophagus | ESCC | 6.55e-09 | 2.61e-01 | 0.116 |
7543 | ZFX | P11T-E | Human | Esophagus | ESCC | 2.40e-13 | 6.03e-01 | 0.1426 |
7543 | ZFX | P12T-E | Human | Esophagus | ESCC | 1.65e-09 | 2.39e-01 | 0.1122 |
7543 | ZFX | P15T-E | Human | Esophagus | ESCC | 4.15e-14 | 4.01e-01 | 0.1149 |
7543 | ZFX | P16T-E | Human | Esophagus | ESCC | 2.43e-06 | 2.77e-01 | 0.1153 |
7543 | ZFX | P17T-E | Human | Esophagus | ESCC | 1.64e-03 | 2.58e-01 | 0.1278 |
7543 | ZFX | P20T-E | Human | Esophagus | ESCC | 1.71e-10 | 2.26e-01 | 0.1124 |
7543 | ZFX | P21T-E | Human | Esophagus | ESCC | 3.63e-13 | 1.74e-01 | 0.1617 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0061458110 | Esophagus | ESCC | reproductive system development | 247/8552 | 427/18723 | 2.24e-07 | 3.42e-06 | 247 |
GO:004860818 | Esophagus | ESCC | reproductive structure development | 245/8552 | 424/18723 | 2.82e-07 | 4.14e-06 | 245 |
GO:0048872111 | Esophagus | ESCC | homeostasis of number of cells | 163/8552 | 272/18723 | 1.40e-06 | 1.69e-05 | 163 |
GO:00097919 | Esophagus | ESCC | post-embryonic development | 56/8552 | 80/18723 | 9.08e-06 | 8.71e-05 | 56 |
GO:00352647 | Esophagus | ESCC | multicellular organism growth | 80/8552 | 132/18723 | 3.84e-04 | 2.22e-03 | 80 |
GO:004887212 | Liver | Cirrhotic | homeostasis of number of cells | 89/4634 | 272/18723 | 1.76e-03 | 1.12e-02 | 89 |
GO:00614585 | Liver | Cirrhotic | reproductive system development | 132/4634 | 427/18723 | 2.07e-03 | 1.28e-02 | 132 |
GO:00486085 | Liver | Cirrhotic | reproductive structure development | 131/4634 | 424/18723 | 2.19e-03 | 1.34e-02 | 131 |
GO:003526411 | Liver | Cirrhotic | multicellular organism growth | 47/4634 | 132/18723 | 3.40e-03 | 1.89e-02 | 47 |
GO:004887222 | Liver | HCC | homeostasis of number of cells | 147/7958 | 272/18723 | 7.48e-05 | 6.70e-04 | 147 |
GO:003526421 | Liver | HCC | multicellular organism growth | 70/7958 | 132/18723 | 9.29e-03 | 3.57e-02 | 70 |
GO:006145811 | Liver | HCC | reproductive system development | 205/7958 | 427/18723 | 1.16e-02 | 4.27e-02 | 205 |
GO:00614586 | Lung | IAC | reproductive system development | 79/2061 | 427/18723 | 2.39e-06 | 1.06e-04 | 79 |
GO:00486086 | Lung | IAC | reproductive structure development | 78/2061 | 424/18723 | 3.44e-06 | 1.44e-04 | 78 |
GO:00488728 | Lung | IAC | homeostasis of number of cells | 54/2061 | 272/18723 | 1.20e-05 | 3.64e-04 | 54 |
GO:00352644 | Lung | IAC | multicellular organism growth | 25/2061 | 132/18723 | 4.69e-03 | 3.68e-02 | 25 |
GO:006145812 | Lung | AIS | reproductive system development | 70/1849 | 427/18723 | 1.52e-05 | 5.50e-04 | 70 |
GO:004860811 | Lung | AIS | reproductive structure development | 69/1849 | 424/18723 | 2.23e-05 | 7.42e-04 | 69 |
GO:004887213 | Lung | AIS | homeostasis of number of cells | 47/1849 | 272/18723 | 1.03e-04 | 2.50e-03 | 47 |
GO:0008585 | Lung | AIS | female gonad development | 19/1849 | 95/18723 | 2.13e-03 | 2.30e-02 | 19 |
Page: 1 2 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZFX | SNV | Missense_Mutation | novel | c.2425N>G | p.His809Asp | p.H809D | P17010 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-55-8299-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
ZFX | SNV | Missense_Mutation | c.504G>T | p.Met168Ile | p.M168I | P17010 | protein_coding | tolerated(0.55) | benign(0) | TCGA-78-7158-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD | |
ZFX | SNV | Missense_Mutation | c.1513N>G | p.Asn505Asp | p.N505D | P17010 | protein_coding | deleterious(0.01) | possibly_damaging(0.842) | TCGA-91-6835-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZFX | SNV | Missense_Mutation | novel | c.1418N>A | p.Phe473Tyr | p.F473Y | P17010 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-22-1016-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZFX | SNV | Missense_Mutation | novel | c.542C>T | p.Ser181Phe | p.S181F | P17010 | protein_coding | deleterious(0.02) | possibly_damaging(0.567) | TCGA-37-A5EN-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
ZFX | SNV | Missense_Mutation | novel | c.1522A>G | p.Ile508Val | p.I508V | P17010 | protein_coding | tolerated(1) | benign(0.014) | TCGA-51-6867-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ZFX | SNV | Missense_Mutation | novel | c.2061G>C | p.Leu687Phe | p.L687F | P17010 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-77-7140-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ZFX | SNV | Missense_Mutation | c.2141C>T | p.Ser714Leu | p.S714L | P17010 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-85-A4CL-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZFX | SNV | Missense_Mutation | novel | c.259G>T | p.Asp87Tyr | p.D87Y | P17010 | protein_coding | deleterious(0.02) | probably_damaging(0.935) | TCGA-98-A538-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZFX | SNV | Missense_Mutation | rs748417793 | c.2474N>A | p.Arg825Gln | p.R825Q | P17010 | protein_coding | deleterious(0.05) | benign(0.351) | TCGA-CV-A463-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |