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Gene: ZFC3H1 |
Gene summary for ZFC3H1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ZFC3H1 | Gene ID | 196441 |
Gene name | zinc finger C3H1-type containing | |
Gene Alias | CCDC131 | |
Cytomap | 12q21.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | O60293 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
196441 | ZFC3H1 | CCI_1 | Human | Cervix | CC | 2.43e-03 | 6.71e-01 | 0.528 |
196441 | ZFC3H1 | CCI_2 | Human | Cervix | CC | 3.77e-16 | 1.39e+00 | 0.5249 |
196441 | ZFC3H1 | CCI_3 | Human | Cervix | CC | 5.12e-16 | 1.13e+00 | 0.516 |
196441 | ZFC3H1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.89e-16 | -5.94e-01 | 0.0155 |
196441 | ZFC3H1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.72e-07 | -5.84e-01 | -0.1808 |
196441 | ZFC3H1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.67e-03 | -4.35e-01 | -0.0811 |
196441 | ZFC3H1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.43e-02 | -3.81e-01 | -0.1088 |
196441 | ZFC3H1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.53e-05 | -5.60e-01 | -0.1207 |
196441 | ZFC3H1 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.19e-02 | -3.75e-01 | -0.1526 |
196441 | ZFC3H1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.66e-09 | -4.49e-01 | -0.1464 |
196441 | ZFC3H1 | HTA11_866_2000001011 | Human | Colorectum | AD | 6.44e-03 | -3.58e-01 | -0.1001 |
196441 | ZFC3H1 | HTA11_866_3004761011 | Human | Colorectum | AD | 8.33e-12 | -5.24e-01 | 0.096 |
196441 | ZFC3H1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 5.60e-04 | -3.96e-01 | 0.0338 |
196441 | ZFC3H1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.59e-04 | -3.48e-01 | 0.0674 |
196441 | ZFC3H1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.35e-06 | -5.17e-01 | 0.0588 |
196441 | ZFC3H1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 8.83e-04 | -3.57e-01 | 0.294 |
196441 | ZFC3H1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.28e-03 | -5.76e-01 | 0.2585 |
196441 | ZFC3H1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.37e-12 | -5.39e-01 | 0.3005 |
196441 | ZFC3H1 | A001-C-207 | Human | Colorectum | FAP | 4.91e-02 | -2.89e-02 | 0.1278 |
196441 | ZFC3H1 | A015-C-203 | Human | Colorectum | FAP | 9.89e-26 | -1.32e-01 | -0.1294 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZFC3H1 | SNV | Missense_Mutation | novel | c.3498A>C | p.Glu1166Asp | p.E1166D | O60293 | protein_coding | tolerated(0.11) | probably_damaging(0.942) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZFC3H1 | SNV | Missense_Mutation | novel | c.2743G>A | p.Glu915Lys | p.E915K | O60293 | protein_coding | tolerated(0.23) | benign(0.426) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZFC3H1 | SNV | Missense_Mutation | rs371029600 | c.2374C>T | p.Arg792Cys | p.R792C | O60293 | protein_coding | deleterious(0) | possibly_damaging(0.858) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZFC3H1 | SNV | Missense_Mutation | c.2228G>A | p.Arg743Gln | p.R743Q | O60293 | protein_coding | tolerated(0.1) | probably_damaging(0.988) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZFC3H1 | SNV | Missense_Mutation | novel | c.3708A>C | p.Glu1236Asp | p.E1236D | O60293 | protein_coding | tolerated(0.33) | benign(0.031) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
ZFC3H1 | SNV | Missense_Mutation | novel | c.3106T>G | p.Leu1036Val | p.L1036V | O60293 | protein_coding | tolerated(0.38) | benign(0.108) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
ZFC3H1 | SNV | Missense_Mutation | novel | c.2000G>T | p.Arg667Ile | p.R667I | O60293 | protein_coding | deleterious(0.01) | probably_damaging(0.916) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
ZFC3H1 | SNV | Missense_Mutation | c.888T>G | p.Phe296Leu | p.F296L | O60293 | protein_coding | deleterious(0.03) | benign(0.007) | TCGA-AX-A063-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZFC3H1 | SNV | Missense_Mutation | novel | c.3446C>A | p.Pro1149His | p.P1149H | O60293 | protein_coding | deleterious(0) | probably_damaging(0.936) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
ZFC3H1 | SNV | Missense_Mutation | c.5143N>T | p.Arg1715Trp | p.R1715W | O60293 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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