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Gene: USP8 |
Gene summary for USP8 |
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Gene information | Species | Human | Gene symbol | USP8 | Gene ID | 9101 |
Gene name | ubiquitin specific peptidase 8 | |
Gene Alias | HumORF8 | |
Cytomap | 15q21.2 | |
Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | A0A024R5S4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9101 | USP8 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.50e-08 | -4.45e-01 | 0.0155 |
9101 | USP8 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.15e-04 | -4.18e-01 | 0.096 |
9101 | USP8 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.49e-08 | -4.02e-01 | 0.0674 |
9101 | USP8 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.14e-02 | -4.12e-01 | 0.0588 |
9101 | USP8 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 6.72e-07 | -4.70e-01 | 0.294 |
9101 | USP8 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.53e-08 | -4.19e-01 | 0.3859 |
9101 | USP8 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 7.07e-04 | -5.60e-01 | 0.2585 |
9101 | USP8 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 9.94e-06 | -4.04e-01 | 0.3005 |
9101 | USP8 | A015-C-203 | Human | Colorectum | FAP | 1.18e-22 | -1.37e-02 | -0.1294 |
9101 | USP8 | A015-C-204 | Human | Colorectum | FAP | 2.24e-02 | -7.37e-02 | -0.0228 |
9101 | USP8 | A002-C-201 | Human | Colorectum | FAP | 8.61e-07 | -9.31e-02 | 0.0324 |
9101 | USP8 | A002-C-203 | Human | Colorectum | FAP | 3.03e-04 | -1.48e-01 | 0.2786 |
9101 | USP8 | A001-C-119 | Human | Colorectum | FAP | 9.80e-11 | 4.37e-01 | -0.1557 |
9101 | USP8 | A001-C-108 | Human | Colorectum | FAP | 3.33e-13 | 5.48e-02 | -0.0272 |
9101 | USP8 | A002-C-205 | Human | Colorectum | FAP | 2.03e-17 | 4.10e-02 | -0.1236 |
9101 | USP8 | A001-C-104 | Human | Colorectum | FAP | 1.72e-02 | 7.18e-02 | 0.0184 |
9101 | USP8 | A015-C-005 | Human | Colorectum | FAP | 9.54e-03 | -2.15e-01 | -0.0336 |
9101 | USP8 | A015-C-006 | Human | Colorectum | FAP | 4.14e-11 | -1.20e-01 | -0.0994 |
9101 | USP8 | A015-C-106 | Human | Colorectum | FAP | 1.00e-08 | 4.77e-02 | -0.0511 |
9101 | USP8 | A002-C-114 | Human | Colorectum | FAP | 1.08e-12 | -2.42e-02 | -0.1561 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0042176 | Colorectum | AD | regulation of protein catabolic process | 160/3918 | 391/18723 | 1.06e-19 | 7.34e-17 | 160 |
GO:0031647 | Colorectum | AD | regulation of protein stability | 108/3918 | 298/18723 | 6.33e-10 | 5.08e-08 | 108 |
GO:0016050 | Colorectum | AD | vesicle organization | 101/3918 | 300/18723 | 1.65e-07 | 7.17e-06 | 101 |
GO:0071383 | Colorectum | AD | cellular response to steroid hormone stimulus | 73/3918 | 204/18723 | 6.31e-07 | 2.24e-05 | 73 |
GO:1990090 | Colorectum | AD | cellular response to nerve growth factor stimulus | 26/3918 | 53/18723 | 4.87e-06 | 1.28e-04 | 26 |
GO:0030111 | Colorectum | AD | regulation of Wnt signaling pathway | 102/3918 | 328/18723 | 8.51e-06 | 2.03e-04 | 102 |
GO:0007265 | Colorectum | AD | Ras protein signal transduction | 104/3918 | 337/18723 | 1.01e-05 | 2.35e-04 | 104 |
GO:0048545 | Colorectum | AD | response to steroid hormone | 104/3918 | 339/18723 | 1.33e-05 | 2.90e-04 | 104 |
GO:0016055 | Colorectum | AD | Wnt signaling pathway | 130/3918 | 444/18723 | 1.60e-05 | 3.37e-04 | 130 |
GO:1990089 | Colorectum | AD | response to nerve growth factor | 26/3918 | 56/18723 | 1.71e-05 | 3.59e-04 | 26 |
GO:0198738 | Colorectum | AD | cell-cell signaling by wnt | 130/3918 | 446/18723 | 2.02e-05 | 4.10e-04 | 130 |
GO:0000910 | Colorectum | AD | cytokinesis | 59/3918 | 173/18723 | 3.74e-05 | 6.75e-04 | 59 |
GO:0007032 | Colorectum | AD | endosome organization | 33/3918 | 82/18723 | 5.30e-05 | 9.01e-04 | 33 |
GO:0061640 | Colorectum | AD | cytoskeleton-dependent cytokinesis | 37/3918 | 100/18723 | 1.58e-04 | 2.20e-03 | 37 |
GO:0060070 | Colorectum | AD | canonical Wnt signaling pathway | 90/3918 | 303/18723 | 1.76e-04 | 2.38e-03 | 90 |
GO:0060828 | Colorectum | AD | regulation of canonical Wnt signaling pathway | 77/3918 | 253/18723 | 2.19e-04 | 2.87e-03 | 77 |
GO:1901654 | Colorectum | AD | response to ketone | 59/3918 | 194/18723 | 1.14e-03 | 1.04e-02 | 59 |
GO:0030177 | Colorectum | AD | positive regulation of Wnt signaling pathway | 45/3918 | 140/18723 | 1.23e-03 | 1.09e-02 | 45 |
GO:0000281 | Colorectum | AD | mitotic cytokinesis | 25/3918 | 71/18723 | 3.77e-03 | 2.65e-02 | 25 |
GO:0099170 | Colorectum | AD | postsynaptic modulation of chemical synaptic transmission | 8/3918 | 15/18723 | 5.67e-03 | 3.64e-02 | 8 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04144 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa04137 | Colorectum | AD | Mitophagy - animal | 29/2092 | 72/8465 | 2.49e-03 | 1.35e-02 | 8.59e-03 | 29 |
hsa041441 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa041371 | Colorectum | AD | Mitophagy - animal | 29/2092 | 72/8465 | 2.49e-03 | 1.35e-02 | 8.59e-03 | 29 |
hsa041444 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa041374 | Colorectum | MSS | Mitophagy - animal | 27/1875 | 72/8465 | 2.17e-03 | 1.10e-02 | 6.76e-03 | 27 |
hsa041445 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa041375 | Colorectum | MSS | Mitophagy - animal | 27/1875 | 72/8465 | 2.17e-03 | 1.10e-02 | 6.76e-03 | 27 |
hsa041446 | Colorectum | FAP | Endocytosis | 78/1404 | 251/8465 | 6.20e-09 | 2.96e-07 | 1.80e-07 | 78 |
hsa041378 | Colorectum | FAP | Mitophagy - animal | 20/1404 | 72/8465 | 1.14e-02 | 3.92e-02 | 2.38e-02 | 20 |
hsa041447 | Colorectum | FAP | Endocytosis | 78/1404 | 251/8465 | 6.20e-09 | 2.96e-07 | 1.80e-07 | 78 |
hsa041379 | Colorectum | FAP | Mitophagy - animal | 20/1404 | 72/8465 | 1.14e-02 | 3.92e-02 | 2.38e-02 | 20 |
hsa041448 | Colorectum | CRC | Endocytosis | 65/1091 | 251/8465 | 1.27e-08 | 1.06e-06 | 7.19e-07 | 65 |
hsa0413710 | Colorectum | CRC | Mitophagy - animal | 17/1091 | 72/8465 | 8.74e-03 | 4.00e-02 | 2.71e-02 | 17 |
hsa041449 | Colorectum | CRC | Endocytosis | 65/1091 | 251/8465 | 1.27e-08 | 1.06e-06 | 7.19e-07 | 65 |
hsa0413711 | Colorectum | CRC | Mitophagy - animal | 17/1091 | 72/8465 | 8.74e-03 | 4.00e-02 | 2.71e-02 | 17 |
hsa0414429 | Esophagus | HGIN | Endocytosis | 76/1383 | 251/8465 | 1.74e-08 | 3.34e-07 | 2.65e-07 | 76 |
hsa0413730 | Esophagus | HGIN | Mitophagy - animal | 23/1383 | 72/8465 | 7.69e-04 | 7.59e-03 | 6.03e-03 | 23 |
hsa04144113 | Esophagus | HGIN | Endocytosis | 76/1383 | 251/8465 | 1.74e-08 | 3.34e-07 | 2.65e-07 | 76 |
hsa04137113 | Esophagus | HGIN | Mitophagy - animal | 23/1383 | 72/8465 | 7.69e-04 | 7.59e-03 | 6.03e-03 | 23 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
USP8 | SNV | Missense_Mutation | novel | c.3275N>G | p.Ser1092Cys | p.S1092C | P40818 | protein_coding | deleterious(0) | benign(0.342) | TCGA-05-4424-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Targeted Molecular therapy | erlotinib | SD |
USP8 | SNV | Missense_Mutation | c.272N>T | p.Gly91Val | p.G91V | P40818 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-44-2656-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
USP8 | SNV | Missense_Mutation | c.920G>T | p.Cys307Phe | p.C307F | P40818 | protein_coding | tolerated(1) | benign(0.028) | TCGA-55-7726-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
USP8 | SNV | Missense_Mutation | novel | c.2087N>C | p.His696Pro | p.H696P | P40818 | protein_coding | tolerated(0.33) | benign(0.005) | TCGA-55-8089-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
USP8 | SNV | Missense_Mutation | c.1265N>C | p.Arg422Thr | p.R422T | P40818 | protein_coding | deleterious(0.04) | benign(0.01) | TCGA-78-7150-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD | |
USP8 | SNV | Missense_Mutation | c.1913G>C | p.Arg638Thr | p.R638T | P40818 | protein_coding | deleterious(0) | possibly_damaging(0.803) | TCGA-78-8660-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
USP8 | SNV | Missense_Mutation | novel | c.1488G>T | p.Lys496Asn | p.K496N | P40818 | protein_coding | tolerated(0.25) | benign(0.01) | TCGA-86-A4D0-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | etoposide | CR |
USP8 | SNV | Missense_Mutation | c.1913N>A | p.Arg638Lys | p.R638K | P40818 | protein_coding | tolerated(0.14) | possibly_damaging(0.728) | TCGA-99-8025-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | gemzar | SD | |
USP8 | SNV | Missense_Mutation | c.631N>G | p.Gln211Glu | p.Q211E | P40818 | protein_coding | tolerated(0.52) | benign(0.003) | TCGA-18-3410-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
USP8 | SNV | Missense_Mutation | novel | c.137C>A | p.Thr46Lys | p.T46K | P40818 | protein_coding | tolerated(0.24) | benign(0) | TCGA-22-A5C4-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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