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Gene: USP31 |
Gene summary for USP31 |
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Gene information | Species | Human | Gene symbol | USP31 | Gene ID | 57478 |
Gene name | ubiquitin specific peptidase 31 | |
Gene Alias | USP31 | |
Cytomap | 16p12.2 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q70CQ4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57478 | USP31 | CA_HPV_3 | Human | Cervix | CC | 2.16e-03 | 1.03e-01 | 0.0414 |
57478 | USP31 | CCI_2 | Human | Cervix | CC | 1.26e-08 | 1.09e+00 | 0.5249 |
57478 | USP31 | CCI_3 | Human | Cervix | CC | 6.98e-13 | 1.10e+00 | 0.516 |
57478 | USP31 | LZE4T | Human | Esophagus | ESCC | 3.81e-08 | 1.88e-01 | 0.0811 |
57478 | USP31 | LZE7T | Human | Esophagus | ESCC | 2.67e-04 | 1.69e-01 | 0.0667 |
57478 | USP31 | LZE24T | Human | Esophagus | ESCC | 3.90e-02 | 3.98e-02 | 0.0596 |
57478 | USP31 | P2T-E | Human | Esophagus | ESCC | 2.38e-23 | 5.88e-01 | 0.1177 |
57478 | USP31 | P4T-E | Human | Esophagus | ESCC | 1.85e-06 | 1.97e-01 | 0.1323 |
57478 | USP31 | P5T-E | Human | Esophagus | ESCC | 1.20e-11 | 2.20e-01 | 0.1327 |
57478 | USP31 | P8T-E | Human | Esophagus | ESCC | 2.30e-18 | 4.15e-01 | 0.0889 |
57478 | USP31 | P10T-E | Human | Esophagus | ESCC | 2.32e-22 | 4.15e-01 | 0.116 |
57478 | USP31 | P11T-E | Human | Esophagus | ESCC | 1.69e-07 | 3.96e-01 | 0.1426 |
57478 | USP31 | P12T-E | Human | Esophagus | ESCC | 9.92e-20 | 4.69e-01 | 0.1122 |
57478 | USP31 | P15T-E | Human | Esophagus | ESCC | 1.87e-13 | 3.32e-01 | 0.1149 |
57478 | USP31 | P16T-E | Human | Esophagus | ESCC | 9.54e-07 | 1.27e-01 | 0.1153 |
57478 | USP31 | P17T-E | Human | Esophagus | ESCC | 2.70e-07 | 2.40e-01 | 0.1278 |
57478 | USP31 | P21T-E | Human | Esophagus | ESCC | 2.96e-15 | 2.44e-01 | 0.1617 |
57478 | USP31 | P22T-E | Human | Esophagus | ESCC | 1.29e-15 | 2.73e-01 | 0.1236 |
57478 | USP31 | P23T-E | Human | Esophagus | ESCC | 2.03e-04 | 1.34e-01 | 0.108 |
57478 | USP31 | P24T-E | Human | Esophagus | ESCC | 8.52e-08 | 1.76e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007064612 | Esophagus | ESCC | protein modification by small protein removal | 95/8552 | 157/18723 | 1.25e-04 | 8.56e-04 | 95 |
GO:00165793 | Esophagus | ESCC | protein deubiquitination | 79/8552 | 139/18723 | 5.23e-03 | 1.97e-02 | 79 |
GO:00706462 | Oral cavity | OSCC | protein modification by small protein removal | 77/7305 | 157/18723 | 6.55e-03 | 2.43e-02 | 77 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
USP31 | SNV | Missense_Mutation | c.3305A>C | p.Lys1102Thr | p.K1102T | Q70CQ4 | protein_coding | tolerated_low_confidence(0.27) | benign(0.1) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
USP31 | SNV | Missense_Mutation | c.3060G>T | p.Glu1020Asp | p.E1020D | Q70CQ4 | protein_coding | tolerated_low_confidence(0.25) | benign(0.001) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
USP31 | SNV | Missense_Mutation | novel | c.2096G>A | p.Gly699Glu | p.G699E | Q70CQ4 | protein_coding | tolerated(0.07) | probably_damaging(0.993) | TCGA-BS-A0V4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
USP31 | SNV | Missense_Mutation | rs370063502 | c.1360N>A | p.Asp454Asn | p.D454N | Q70CQ4 | protein_coding | tolerated(0.29) | probably_damaging(0.963) | TCGA-D1-A101-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
USP31 | SNV | Missense_Mutation | c.3808G>A | p.Glu1270Lys | p.E1270K | Q70CQ4 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
USP31 | SNV | Missense_Mutation | novel | c.3491G>A | p.Gly1164Asp | p.G1164D | Q70CQ4 | protein_coding | tolerated_low_confidence(0.4) | benign(0.109) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
USP31 | SNV | Missense_Mutation | rs767372505 | c.1147G>A | p.Asp383Asn | p.D383N | Q70CQ4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
USP31 | SNV | Missense_Mutation | novel | c.1039G>A | p.Ala347Thr | p.A347T | Q70CQ4 | protein_coding | tolerated(0.05) | possibly_damaging(0.712) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
USP31 | SNV | Missense_Mutation | novel | c.2795N>A | p.Arg932His | p.R932H | Q70CQ4 | protein_coding | tolerated_low_confidence(0.63) | benign(0.015) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
USP31 | SNV | Missense_Mutation | rs763067770 | c.2375N>A | p.Arg792Gln | p.R792Q | Q70CQ4 | protein_coding | deleterious(0.02) | probably_damaging(0.995) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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