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Gene: UHRF1BP1L |
Gene summary for UHRF1BP1L |
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Gene information | Species | Human | Gene symbol | UHRF1BP1L | Gene ID | 23074 |
Gene name | UHRF1 binding protein 1 like | |
Gene Alias | SHIP164 | |
Cytomap | 12q23.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0JNW5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23074 | UHRF1BP1L | LZE4T | Human | Esophagus | ESCC | 1.76e-13 | 2.00e-01 | 0.0811 |
23074 | UHRF1BP1L | LZE7T | Human | Esophagus | ESCC | 2.33e-04 | 2.49e-01 | 0.0667 |
23074 | UHRF1BP1L | LZE8T | Human | Esophagus | ESCC | 3.28e-03 | 8.14e-02 | 0.067 |
23074 | UHRF1BP1L | LZE24T | Human | Esophagus | ESCC | 5.07e-12 | 2.66e-01 | 0.0596 |
23074 | UHRF1BP1L | P2T-E | Human | Esophagus | ESCC | 6.01e-40 | 6.97e-01 | 0.1177 |
23074 | UHRF1BP1L | P4T-E | Human | Esophagus | ESCC | 7.83e-12 | 2.15e-01 | 0.1323 |
23074 | UHRF1BP1L | P5T-E | Human | Esophagus | ESCC | 7.38e-07 | 1.27e-01 | 0.1327 |
23074 | UHRF1BP1L | P8T-E | Human | Esophagus | ESCC | 3.06e-08 | 1.66e-01 | 0.0889 |
23074 | UHRF1BP1L | P9T-E | Human | Esophagus | ESCC | 1.34e-07 | 1.70e-01 | 0.1131 |
23074 | UHRF1BP1L | P10T-E | Human | Esophagus | ESCC | 3.44e-10 | 1.10e-01 | 0.116 |
23074 | UHRF1BP1L | P11T-E | Human | Esophagus | ESCC | 3.49e-10 | 5.10e-01 | 0.1426 |
23074 | UHRF1BP1L | P12T-E | Human | Esophagus | ESCC | 8.52e-14 | 2.91e-01 | 0.1122 |
23074 | UHRF1BP1L | P15T-E | Human | Esophagus | ESCC | 4.98e-16 | 3.25e-01 | 0.1149 |
23074 | UHRF1BP1L | P16T-E | Human | Esophagus | ESCC | 3.24e-11 | 2.70e-01 | 0.1153 |
23074 | UHRF1BP1L | P17T-E | Human | Esophagus | ESCC | 5.45e-03 | 1.06e-01 | 0.1278 |
23074 | UHRF1BP1L | P19T-E | Human | Esophagus | ESCC | 1.51e-02 | 2.94e-01 | 0.1662 |
23074 | UHRF1BP1L | P20T-E | Human | Esophagus | ESCC | 4.81e-12 | 2.45e-01 | 0.1124 |
23074 | UHRF1BP1L | P21T-E | Human | Esophagus | ESCC | 8.99e-12 | 2.27e-01 | 0.1617 |
23074 | UHRF1BP1L | P22T-E | Human | Esophagus | ESCC | 5.00e-07 | 1.82e-01 | 0.1236 |
23074 | UHRF1BP1L | P23T-E | Human | Esophagus | ESCC | 3.56e-11 | 3.36e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UHRF1BP1L | SNV | Missense_Mutation | rs771147002 | c.3620N>A | p.Arg1207Gln | p.R1207Q | A0JNW5 | protein_coding | tolerated(0.08) | benign(0.182) | TCGA-AX-A3G3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
UHRF1BP1L | SNV | Missense_Mutation | c.3323C>A | p.Ser1108Tyr | p.S1108Y | A0JNW5 | protein_coding | deleterious(0.01) | benign(0.305) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
UHRF1BP1L | SNV | Missense_Mutation | c.1805N>C | p.Ile602Thr | p.I602T | A0JNW5 | protein_coding | deleterious(0) | benign(0.342) | TCGA-B5-A0JZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD | |
UHRF1BP1L | SNV | Missense_Mutation | novel | c.1141G>C | p.Ala381Pro | p.A381P | A0JNW5 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-B5-A11I-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | PD |
UHRF1BP1L | SNV | Missense_Mutation | c.670T>G | p.Leu224Val | p.L224V | A0JNW5 | protein_coding | tolerated(0.26) | benign(0.171) | TCGA-B5-A11N-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UHRF1BP1L | SNV | Missense_Mutation | rs765722745 | c.2285N>A | p.Arg762Gln | p.R762Q | A0JNW5 | protein_coding | deleterious(0.03) | benign(0.266) | TCGA-B5-A11Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UHRF1BP1L | SNV | Missense_Mutation | novel | c.1901N>C | p.Asp634Ala | p.D634A | A0JNW5 | protein_coding | tolerated(0.07) | benign(0.101) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
UHRF1BP1L | SNV | Missense_Mutation | novel | c.1222N>G | p.Lys408Glu | p.K408E | A0JNW5 | protein_coding | tolerated(0.27) | benign(0.003) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
UHRF1BP1L | SNV | Missense_Mutation | novel | c.2995N>G | p.Lys999Glu | p.K999E | A0JNW5 | protein_coding | tolerated(0.71) | benign(0.034) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
UHRF1BP1L | SNV | Missense_Mutation | rs771456030 | c.2084N>T | p.Ala695Val | p.A695V | A0JNW5 | protein_coding | deleterious(0.02) | possibly_damaging(0.829) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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