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Gene: UGT3A2 |
Gene summary for UGT3A2 |
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Gene information | Species | Human | Gene symbol | UGT3A2 | Gene ID | 167127 |
Gene name | UDP glycosyltransferase family 3 member A2 | |
Gene Alias | UGT3A2 | |
Cytomap | 5p13.2 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q3SY77 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
167127 | UGT3A2 | S014 | Human | Liver | HCC | 2.66e-13 | 4.30e-01 | 0.2254 |
167127 | UGT3A2 | S015 | Human | Liver | HCC | 7.14e-27 | 1.06e+00 | 0.2375 |
167127 | UGT3A2 | S016 | Human | Liver | HCC | 4.24e-18 | 5.04e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190165422 | Liver | HCC | response to ketone | 119/7958 | 194/18723 | 8.65e-08 | 1.72e-06 | 119 |
GO:19016552 | Liver | HCC | cellular response to ketone | 58/7958 | 96/18723 | 2.99e-04 | 2.13e-03 | 58 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UGT3A2 | SNV | Missense_Mutation | c.695N>A | p.Gly232Asp | p.G232D | Q3SY77 | protein_coding | tolerated(0.07) | benign(0.077) | TCGA-22-4613-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UGT3A2 | SNV | Missense_Mutation | c.285C>A | p.Phe95Leu | p.F95L | Q3SY77 | protein_coding | tolerated(0.67) | benign(0.003) | TCGA-34-5240-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | CR | |
UGT3A2 | SNV | Missense_Mutation | novel | c.307N>T | p.Gly103Cys | p.G103C | Q3SY77 | protein_coding | deleterious(0.01) | probably_damaging(0.943) | TCGA-39-5034-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
UGT3A2 | SNV | Missense_Mutation | c.358C>G | p.Gln120Glu | p.Q120E | Q3SY77 | protein_coding | tolerated(0.07) | benign(0.338) | TCGA-56-5897-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
UGT3A2 | SNV | Missense_Mutation | rs201394842 | c.1361G>A | p.Arg454Gln | p.R454Q | Q3SY77 | protein_coding | tolerated(0.11) | probably_damaging(0.993) | TCGA-56-7222-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
UGT3A2 | SNV | Missense_Mutation | c.1523N>A | p.Gly508Asp | p.G508D | Q3SY77 | protein_coding | tolerated(0.13) | probably_damaging(0.994) | TCGA-66-2789-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
UGT3A2 | SNV | Missense_Mutation | c.702N>T | p.Arg234Ser | p.R234S | Q3SY77 | protein_coding | deleterious(0.03) | probably_damaging(0.966) | TCGA-66-2792-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | CR | |
UGT3A2 | SNV | Missense_Mutation | c.398N>G | p.Ser133Cys | p.S133C | Q3SY77 | protein_coding | tolerated(0.17) | probably_damaging(0.956) | TCGA-77-8140-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UGT3A2 | SNV | Missense_Mutation | novel | c.301N>A | p.Leu101Ile | p.L101I | Q3SY77 | protein_coding | tolerated(0.06) | benign(0.324) | TCGA-85-8580-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UGT3A2 | SNV | Missense_Mutation | novel | c.377N>G | p.Asn126Ser | p.N126S | Q3SY77 | protein_coding | tolerated(0.75) | benign(0.003) | TCGA-85-A4JB-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | unknown | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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