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Gene: TUBGCP2 |
Gene summary for TUBGCP2 |
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Gene information | Species | Human | Gene symbol | TUBGCP2 | Gene ID | 10844 |
Gene name | tubulin gamma complex associated protein 2 | |
Gene Alias | ALP4 | |
Cytomap | 10q26.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9BSJ2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10844 | TUBGCP2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.30e-02 | -1.85e-02 | 0.0155 |
10844 | TUBGCP2 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.63e-05 | 2.92e-01 | -0.1954 |
10844 | TUBGCP2 | HTA11_83_2000001011 | Human | Colorectum | SER | 5.41e-04 | 4.45e-01 | -0.1526 |
10844 | TUBGCP2 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.79e-09 | 4.28e-01 | -0.1464 |
10844 | TUBGCP2 | HTA11_866_2000001011 | Human | Colorectum | AD | 6.22e-04 | 2.18e-01 | -0.1001 |
10844 | TUBGCP2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.05e-09 | 5.09e-01 | -0.059 |
10844 | TUBGCP2 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.77e-02 | 2.64e-01 | 0.096 |
10844 | TUBGCP2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.81e-02 | 4.76e-01 | 0.0528 |
10844 | TUBGCP2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.24e-06 | 3.33e-01 | 0.0674 |
10844 | TUBGCP2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.69e-02 | 3.44e-01 | 0.0588 |
10844 | TUBGCP2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.33e-10 | 5.61e-01 | 0.3859 |
10844 | TUBGCP2 | A015-C-203 | Human | Colorectum | FAP | 1.91e-02 | -6.93e-02 | -0.1294 |
10844 | TUBGCP2 | A015-C-104 | Human | Colorectum | FAP | 1.02e-03 | 4.80e-02 | -0.1899 |
10844 | TUBGCP2 | A002-C-116 | Human | Colorectum | FAP | 2.41e-02 | -9.07e-02 | -0.0452 |
10844 | TUBGCP2 | LZE2T | Human | Esophagus | ESCC | 2.65e-03 | 3.26e-01 | 0.082 |
10844 | TUBGCP2 | LZE4T | Human | Esophagus | ESCC | 1.22e-09 | 3.34e-01 | 0.0811 |
10844 | TUBGCP2 | LZE7T | Human | Esophagus | ESCC | 1.70e-02 | 1.42e-01 | 0.0667 |
10844 | TUBGCP2 | LZE8T | Human | Esophagus | ESCC | 2.62e-03 | 1.86e-01 | 0.067 |
10844 | TUBGCP2 | LZE20T | Human | Esophagus | ESCC | 4.90e-09 | 1.82e-01 | 0.0662 |
10844 | TUBGCP2 | LZE24T | Human | Esophagus | ESCC | 8.42e-23 | 6.52e-01 | 0.0596 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051258 | Colorectum | AD | protein polymerization | 112/3918 | 297/18723 | 1.85e-11 | 2.27e-09 | 112 |
GO:0007051 | Colorectum | AD | spindle organization | 58/3918 | 184/18723 | 4.71e-04 | 5.20e-03 | 58 |
GO:0051225 | Colorectum | AD | spindle assembly | 37/3918 | 117/18723 | 4.32e-03 | 2.96e-02 | 37 |
GO:00512581 | Colorectum | SER | protein polymerization | 91/2897 | 297/18723 | 2.72e-11 | 5.06e-09 | 91 |
GO:00512582 | Colorectum | MSS | protein polymerization | 97/3467 | 297/18723 | 2.98e-09 | 2.07e-07 | 97 |
GO:00070511 | Colorectum | MSS | spindle organization | 53/3467 | 184/18723 | 4.23e-04 | 5.19e-03 | 53 |
GO:00512251 | Colorectum | MSS | spindle assembly | 33/3467 | 117/18723 | 6.68e-03 | 4.38e-02 | 33 |
GO:00512584 | Colorectum | FAP | protein polymerization | 73/2622 | 297/18723 | 7.11e-07 | 3.32e-05 | 73 |
GO:0031122 | Colorectum | FAP | cytoplasmic microtubule organization | 17/2622 | 56/18723 | 1.24e-03 | 1.16e-02 | 17 |
GO:00070512 | Colorectum | FAP | spindle organization | 41/2622 | 184/18723 | 1.50e-03 | 1.34e-02 | 41 |
GO:000705114 | Esophagus | ESCC | spindle organization | 134/8552 | 184/18723 | 5.70e-14 | 2.87e-12 | 134 |
GO:00512256 | Esophagus | ESCC | spindle assembly | 85/8552 | 117/18723 | 2.72e-09 | 5.98e-08 | 85 |
GO:0051258111 | Esophagus | ESCC | protein polymerization | 183/8552 | 297/18723 | 1.94e-08 | 3.75e-07 | 183 |
GO:00311094 | Esophagus | ESCC | microtubule polymerization or depolymerization | 77/8552 | 122/18723 | 7.60e-05 | 5.68e-04 | 77 |
GO:00467856 | Esophagus | ESCC | microtubule polymerization | 55/8552 | 83/18723 | 1.21e-04 | 8.31e-04 | 55 |
GO:00070205 | Esophagus | ESCC | microtubule nucleation | 27/8552 | 35/18723 | 1.48e-04 | 9.88e-04 | 27 |
GO:00311227 | Esophagus | ESCC | cytoplasmic microtubule organization | 38/8552 | 56/18723 | 6.60e-04 | 3.50e-03 | 38 |
GO:005125812 | Liver | Cirrhotic | protein polymerization | 116/4634 | 297/18723 | 2.87e-08 | 9.78e-07 | 116 |
GO:00070514 | Liver | Cirrhotic | spindle organization | 62/4634 | 184/18723 | 3.88e-03 | 2.10e-02 | 62 |
GO:00512252 | Liver | Cirrhotic | spindle assembly | 41/4634 | 117/18723 | 8.08e-03 | 3.79e-02 | 41 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TUBGCP2 | SNV | Missense_Mutation | novel | c.2176N>C | p.Met726Leu | p.M726L | Q9BSJ2 | protein_coding | deleterious(0.02) | possibly_damaging(0.661) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TUBGCP2 | SNV | Missense_Mutation | novel | c.887N>T | p.Ala296Val | p.A296V | Q9BSJ2 | protein_coding | deleterious(0.01) | benign(0.211) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TUBGCP2 | SNV | Missense_Mutation | rs775586504 | c.2696N>A | p.Arg899His | p.R899H | Q9BSJ2 | protein_coding | tolerated(0.16) | benign(0.006) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
TUBGCP2 | SNV | Missense_Mutation | novel | c.1654N>A | p.Gln552Lys | p.Q552K | Q9BSJ2 | protein_coding | tolerated(0.15) | benign(0.046) | TCGA-EY-A1GK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TUBGCP2 | SNV | Missense_Mutation | novel | c.2645N>A | p.Ser882Asn | p.S882N | Q9BSJ2 | protein_coding | tolerated(1) | benign(0) | TCGA-EY-A1GU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TUBGCP2 | SNV | Missense_Mutation | novel | c.1814N>C | p.Leu605Pro | p.L605P | Q9BSJ2 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-SJ-A6ZI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TUBGCP2 | deletion | Frame_Shift_Del | c.2731delN | p.Gln911LysfsTer25 | p.Q911Kfs*25 | Q9BSJ2 | protein_coding | TCGA-AJ-A2QO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
TUBGCP2 | deletion | Frame_Shift_Del | c.2731delN | p.Gln911LysfsTer25 | p.Q911Kfs*25 | Q9BSJ2 | protein_coding | TCGA-AP-A1DP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | paclitaxel | PD | |||
TUBGCP2 | deletion | Frame_Shift_Del | novel | c.1143delN | p.Ser382ProfsTer3 | p.S382Pfs*3 | Q9BSJ2 | protein_coding | TCGA-BG-A0VW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TUBGCP2 | deletion | Frame_Shift_Del | c.2731delC | p.Gln911LysfsTer25 | p.Q911Kfs*25 | Q9BSJ2 | protein_coding | TCGA-EY-A5W2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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