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Gene: TRAPPC11 |
Gene summary for TRAPPC11 |
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Gene information | Species | Human | Gene symbol | TRAPPC11 | Gene ID | 60684 |
Gene name | trafficking protein particle complex subunit 11 | |
Gene Alias | C4orf41 | |
Cytomap | 4q35.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q7Z392 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
60684 | TRAPPC11 | LZE4T | Human | Esophagus | ESCC | 8.12e-07 | 1.52e-01 | 0.0811 |
60684 | TRAPPC11 | LZE7T | Human | Esophagus | ESCC | 9.50e-07 | 2.36e-01 | 0.0667 |
60684 | TRAPPC11 | LZE8T | Human | Esophagus | ESCC | 1.26e-03 | 7.91e-02 | 0.067 |
60684 | TRAPPC11 | LZE24T | Human | Esophagus | ESCC | 5.20e-07 | 1.40e-01 | 0.0596 |
60684 | TRAPPC11 | P2T-E | Human | Esophagus | ESCC | 7.65e-16 | 2.78e-01 | 0.1177 |
60684 | TRAPPC11 | P4T-E | Human | Esophagus | ESCC | 5.46e-09 | 1.79e-01 | 0.1323 |
60684 | TRAPPC11 | P5T-E | Human | Esophagus | ESCC | 3.21e-06 | 9.62e-02 | 0.1327 |
60684 | TRAPPC11 | P8T-E | Human | Esophagus | ESCC | 6.34e-17 | 1.91e-01 | 0.0889 |
60684 | TRAPPC11 | P9T-E | Human | Esophagus | ESCC | 1.80e-07 | 6.35e-02 | 0.1131 |
60684 | TRAPPC11 | P10T-E | Human | Esophagus | ESCC | 1.94e-10 | 1.06e-01 | 0.116 |
60684 | TRAPPC11 | P11T-E | Human | Esophagus | ESCC | 1.20e-09 | 1.77e-01 | 0.1426 |
60684 | TRAPPC11 | P12T-E | Human | Esophagus | ESCC | 1.85e-19 | 3.46e-01 | 0.1122 |
60684 | TRAPPC11 | P15T-E | Human | Esophagus | ESCC | 3.30e-09 | 1.39e-01 | 0.1149 |
60684 | TRAPPC11 | P16T-E | Human | Esophagus | ESCC | 2.83e-06 | 1.88e-01 | 0.1153 |
60684 | TRAPPC11 | P17T-E | Human | Esophagus | ESCC | 4.27e-04 | 1.10e-01 | 0.1278 |
60684 | TRAPPC11 | P20T-E | Human | Esophagus | ESCC | 8.23e-19 | 2.20e-01 | 0.1124 |
60684 | TRAPPC11 | P21T-E | Human | Esophagus | ESCC | 7.29e-13 | 2.00e-01 | 0.1617 |
60684 | TRAPPC11 | P22T-E | Human | Esophagus | ESCC | 2.85e-07 | 1.75e-01 | 0.1236 |
60684 | TRAPPC11 | P23T-E | Human | Esophagus | ESCC | 3.21e-37 | 7.42e-01 | 0.108 |
60684 | TRAPPC11 | P24T-E | Human | Esophagus | ESCC | 4.20e-09 | 1.09e-01 | 0.1287 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004819318 | Esophagus | ESCC | Golgi vesicle transport | 231/8552 | 296/18723 | 1.82e-30 | 9.63e-28 | 231 |
GO:000688815 | Esophagus | ESCC | endoplasmic reticulum to Golgi vesicle-mediated transport | 102/8552 | 130/18723 | 1.73e-14 | 9.22e-13 | 102 |
GO:00070308 | Esophagus | ESCC | Golgi organization | 101/8552 | 157/18723 | 1.78e-06 | 2.10e-05 | 101 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRAPPC11 | SNV | Missense_Mutation | c.1598G>T | p.Arg533Leu | p.R533L | Q7Z392 | protein_coding | deleterious(0.04) | possibly_damaging(0.76) | TCGA-78-7220-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
TRAPPC11 | SNV | Missense_Mutation | novel | c.2964N>C | p.Arg988Ser | p.R988S | Q7Z392 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-95-7567-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
TRAPPC11 | SNV | Missense_Mutation | c.2062N>T | p.Asp688Tyr | p.D688Y | Q7Z392 | protein_coding | tolerated(0.85) | benign(0.015) | TCGA-97-A4M0-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TRAPPC11 | SNV | Missense_Mutation | c.172N>T | p.Gly58Cys | p.G58C | Q7Z392 | protein_coding | deleterious(0.03) | probably_damaging(0.98) | TCGA-18-3411-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
TRAPPC11 | SNV | Missense_Mutation | novel | c.1369N>T | p.Val457Phe | p.V457F | Q7Z392 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-33-4587-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | etoposide | PD |
TRAPPC11 | SNV | Missense_Mutation | novel | c.2479C>A | p.Pro827Thr | p.P827T | Q7Z392 | protein_coding | tolerated(0.29) | benign(0.159) | TCGA-52-7622-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TRAPPC11 | SNV | Missense_Mutation | novel | c.796N>A | p.Glu266Lys | p.E266K | Q7Z392 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-90-A4ED-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TRAPPC11 | SNV | Missense_Mutation | c.1419N>C | p.Leu473Phe | p.L473F | Q7Z392 | protein_coding | deleterious(0.02) | probably_damaging(0.919) | TCGA-98-7454-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TRAPPC11 | insertion | Frame_Shift_Ins | novel | c.1078_1079insG | p.Lys361GlufsTer9 | p.K361Efs*9 | Q7Z392 | protein_coding | TCGA-50-8457-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
TRAPPC11 | insertion | Frame_Shift_Ins | novel | c.1446_1447insTATC | p.Arg484LeufsTer4 | p.R484Lfs*4 | Q7Z392 | protein_coding | TCGA-64-5774-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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