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Gene: TOX2 |
Gene summary for TOX2 |
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Gene information | Species | Human | Gene symbol | TOX2 | Gene ID | 84969 |
Gene name | TOX high mobility group box family member 2 | |
Gene Alias | C20orf100 | |
Cytomap | 20q13.12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q96NM4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84969 | TOX2 | P2T-E | Human | Esophagus | ESCC | 3.95e-03 | 1.60e-01 | 0.1177 |
84969 | TOX2 | P4T-E | Human | Esophagus | ESCC | 1.29e-02 | 1.12e-01 | 0.1323 |
84969 | TOX2 | P8T-E | Human | Esophagus | ESCC | 1.32e-02 | 1.47e-01 | 0.0889 |
84969 | TOX2 | P10T-E | Human | Esophagus | ESCC | 5.24e-07 | 2.02e-01 | 0.116 |
84969 | TOX2 | P11T-E | Human | Esophagus | ESCC | 1.88e-13 | 5.16e-01 | 0.1426 |
84969 | TOX2 | P15T-E | Human | Esophagus | ESCC | 2.95e-12 | 2.73e-01 | 0.1149 |
84969 | TOX2 | P17T-E | Human | Esophagus | ESCC | 1.11e-04 | 2.12e-01 | 0.1278 |
84969 | TOX2 | P19T-E | Human | Esophagus | ESCC | 4.41e-02 | 2.06e-01 | 0.1662 |
84969 | TOX2 | P20T-E | Human | Esophagus | ESCC | 6.29e-03 | 9.71e-02 | 0.1124 |
84969 | TOX2 | P24T-E | Human | Esophagus | ESCC | 4.00e-06 | 1.32e-01 | 0.1287 |
84969 | TOX2 | P26T-E | Human | Esophagus | ESCC | 9.87e-09 | 1.78e-01 | 0.1276 |
84969 | TOX2 | P31T-E | Human | Esophagus | ESCC | 1.35e-15 | 3.43e-01 | 0.1251 |
84969 | TOX2 | P32T-E | Human | Esophagus | ESCC | 4.38e-09 | 2.11e-01 | 0.1666 |
84969 | TOX2 | P40T-E | Human | Esophagus | ESCC | 1.59e-02 | 1.62e-01 | 0.109 |
84969 | TOX2 | P47T-E | Human | Esophagus | ESCC | 1.19e-03 | 6.75e-02 | 0.1067 |
84969 | TOX2 | P49T-E | Human | Esophagus | ESCC | 7.22e-13 | 8.67e-01 | 0.1768 |
84969 | TOX2 | P52T-E | Human | Esophagus | ESCC | 1.18e-15 | 3.61e-01 | 0.1555 |
84969 | TOX2 | P54T-E | Human | Esophagus | ESCC | 1.61e-04 | 1.80e-01 | 0.0975 |
84969 | TOX2 | P61T-E | Human | Esophagus | ESCC | 3.98e-07 | 2.17e-01 | 0.099 |
84969 | TOX2 | P62T-E | Human | Esophagus | ESCC | 3.35e-08 | 2.40e-01 | 0.1302 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00018908 | Cervix | CC | placenta development | 40/2311 | 144/18723 | 4.59e-07 | 1.77e-05 | 40 |
GO:00614588 | Cervix | CC | reproductive system development | 87/2311 | 427/18723 | 1.37e-06 | 4.55e-05 | 87 |
GO:00486088 | Cervix | CC | reproductive structure development | 86/2311 | 424/18723 | 1.90e-06 | 5.97e-05 | 86 |
GO:00075654 | Cervix | CC | female pregnancy | 43/2311 | 193/18723 | 7.62e-05 | 1.04e-03 | 43 |
GO:00447064 | Cervix | CC | multi-multicellular organism process | 45/2311 | 220/18723 | 4.14e-04 | 4.21e-03 | 45 |
GO:00601353 | Cervix | CC | maternal process involved in female pregnancy | 15/2311 | 62/18723 | 7.30e-03 | 3.92e-02 | 15 |
GO:0001890 | Colorectum | AD | placenta development | 51/3918 | 144/18723 | 3.99e-05 | 7.16e-04 | 51 |
GO:0061458 | Colorectum | AD | reproductive system development | 116/3918 | 427/18723 | 1.11e-03 | 1.01e-02 | 116 |
GO:0048608 | Colorectum | AD | reproductive structure development | 114/3918 | 424/18723 | 1.78e-03 | 1.47e-02 | 114 |
GO:00018902 | Colorectum | MSS | placenta development | 51/3467 | 144/18723 | 1.10e-06 | 3.77e-05 | 51 |
GO:00614582 | Colorectum | MSS | reproductive system development | 115/3467 | 427/18723 | 9.86e-06 | 2.39e-04 | 115 |
GO:00486082 | Colorectum | MSS | reproductive structure development | 113/3467 | 424/18723 | 1.94e-05 | 4.18e-04 | 113 |
GO:0001893 | Colorectum | MSS | maternal placenta development | 13/3467 | 35/18723 | 7.38e-03 | 4.68e-02 | 13 |
GO:00018903 | Colorectum | FAP | placenta development | 38/2622 | 144/18723 | 6.22e-05 | 1.21e-03 | 38 |
GO:00614583 | Colorectum | FAP | reproductive system development | 85/2622 | 427/18723 | 4.30e-04 | 5.13e-03 | 85 |
GO:00486083 | Colorectum | FAP | reproductive structure development | 84/2622 | 424/18723 | 5.40e-04 | 6.10e-03 | 84 |
GO:00614589 | Endometrium | AEH | reproductive system development | 88/2100 | 427/18723 | 9.50e-09 | 6.41e-07 | 88 |
GO:00486089 | Endometrium | AEH | reproductive structure development | 87/2100 | 424/18723 | 1.43e-08 | 9.12e-07 | 87 |
GO:00018909 | Endometrium | AEH | placenta development | 39/2100 | 144/18723 | 1.07e-07 | 5.20e-06 | 39 |
GO:00075655 | Endometrium | AEH | female pregnancy | 43/2100 | 193/18723 | 7.52e-06 | 1.80e-04 | 43 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TOX2 | SNV | Missense_Mutation | c.1453C>A | p.Pro485Thr | p.P485T | Q96NM4 | protein_coding | tolerated(0.31) | possibly_damaging(0.714) | TCGA-HF-7136-01 | Stomach | stomach adenocarcinoma | Male | Unknown | III/IV | Unspecific | Cepecitabine | SD | |
TOX2 | SNV | Missense_Mutation | novel | c.1483N>G | p.Ser495Gly | p.S495G | Q96NM4 | protein_coding | tolerated_low_confidence(0.1) | benign(0.058) | TCGA-R5-A7ZI-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TOX2 | SNV | Missense_Mutation | novel | c.191N>G | p.Asn64Ser | p.N64S | Q96NM4 | protein_coding | tolerated(0.27) | probably_damaging(0.987) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
TOX2 | deletion | Frame_Shift_Del | novel | c.212delC | p.Pro71ArgfsTer2 | p.P71Rfs*2 | Q96NM4 | protein_coding | TCGA-HU-A4H4-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | ts-1 | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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