![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: TLE1 |
Gene summary for TLE1 |
![]() |
Gene information | Species | Human | Gene symbol | TLE1 | Gene ID | 7088 |
Gene name | TLE family member 1, transcriptional corepressor | |
Gene Alias | ESG | |
Cytomap | 9q21.32 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q04724 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7088 | TLE1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 9.03e-05 | -2.81e-01 | 0.0155 |
7088 | TLE1 | HTA11_347_2000001011 | Human | Colorectum | AD | 8.12e-03 | 4.32e-01 | -0.1954 |
7088 | TLE1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.59e-11 | -4.85e-01 | 0.294 |
7088 | TLE1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.38e-12 | -4.75e-01 | 0.3005 |
7088 | TLE1 | A015-C-203 | Human | Colorectum | FAP | 9.26e-20 | -3.61e-01 | -0.1294 |
7088 | TLE1 | A015-C-204 | Human | Colorectum | FAP | 3.25e-05 | -2.37e-01 | -0.0228 |
7088 | TLE1 | A014-C-040 | Human | Colorectum | FAP | 9.50e-03 | -2.36e-01 | -0.1184 |
7088 | TLE1 | A002-C-201 | Human | Colorectum | FAP | 2.47e-08 | -8.65e-02 | 0.0324 |
7088 | TLE1 | A002-C-203 | Human | Colorectum | FAP | 1.12e-02 | 1.23e-01 | 0.2786 |
7088 | TLE1 | A001-C-119 | Human | Colorectum | FAP | 1.18e-04 | -3.30e-01 | -0.1557 |
7088 | TLE1 | A001-C-108 | Human | Colorectum | FAP | 1.52e-13 | -2.66e-01 | -0.0272 |
7088 | TLE1 | A002-C-205 | Human | Colorectum | FAP | 6.91e-17 | -2.90e-01 | -0.1236 |
7088 | TLE1 | A001-C-104 | Human | Colorectum | FAP | 5.74e-03 | -2.31e-01 | 0.0184 |
7088 | TLE1 | A015-C-005 | Human | Colorectum | FAP | 2.02e-05 | -1.79e-01 | -0.0336 |
7088 | TLE1 | A015-C-006 | Human | Colorectum | FAP | 1.71e-16 | -5.15e-01 | -0.0994 |
7088 | TLE1 | A015-C-106 | Human | Colorectum | FAP | 4.30e-11 | -2.97e-01 | -0.0511 |
7088 | TLE1 | A002-C-114 | Human | Colorectum | FAP | 7.73e-17 | -3.65e-01 | -0.1561 |
7088 | TLE1 | A015-C-104 | Human | Colorectum | FAP | 1.84e-24 | -4.72e-01 | -0.1899 |
7088 | TLE1 | A001-C-014 | Human | Colorectum | FAP | 2.60e-11 | -1.46e-01 | 0.0135 |
7088 | TLE1 | A002-C-016 | Human | Colorectum | FAP | 3.85e-17 | -9.11e-02 | 0.0521 |
Page: 1 2 3 4 5 6 7 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0030111 | Colorectum | AD | regulation of Wnt signaling pathway | 102/3918 | 328/18723 | 8.51e-06 | 2.03e-04 | 102 |
GO:0016055 | Colorectum | AD | Wnt signaling pathway | 130/3918 | 444/18723 | 1.60e-05 | 3.37e-04 | 130 |
GO:0198738 | Colorectum | AD | cell-cell signaling by wnt | 130/3918 | 446/18723 | 2.02e-05 | 4.10e-04 | 130 |
GO:0060070 | Colorectum | AD | canonical Wnt signaling pathway | 90/3918 | 303/18723 | 1.76e-04 | 2.38e-03 | 90 |
GO:0043122 | Colorectum | AD | regulation of I-kappaB kinase/NF-kappaB signaling | 76/3918 | 249/18723 | 2.17e-04 | 2.85e-03 | 76 |
GO:0060828 | Colorectum | AD | regulation of canonical Wnt signaling pathway | 77/3918 | 253/18723 | 2.19e-04 | 2.87e-03 | 77 |
GO:0007249 | Colorectum | AD | I-kappaB kinase/NF-kappaB signaling | 82/3918 | 281/18723 | 6.09e-04 | 6.40e-03 | 82 |
GO:00301112 | Colorectum | MSS | regulation of Wnt signaling pathway | 98/3467 | 328/18723 | 3.37e-07 | 1.36e-05 | 98 |
GO:00160552 | Colorectum | MSS | Wnt signaling pathway | 124/3467 | 444/18723 | 6.06e-07 | 2.26e-05 | 124 |
GO:01987382 | Colorectum | MSS | cell-cell signaling by wnt | 124/3467 | 446/18723 | 7.83e-07 | 2.77e-05 | 124 |
GO:00600702 | Colorectum | MSS | canonical Wnt signaling pathway | 86/3467 | 303/18723 | 1.58e-05 | 3.56e-04 | 86 |
GO:00608282 | Colorectum | MSS | regulation of canonical Wnt signaling pathway | 74/3467 | 253/18723 | 1.99e-05 | 4.26e-04 | 74 |
GO:00431221 | Colorectum | MSS | regulation of I-kappaB kinase/NF-kappaB signaling | 71/3467 | 249/18723 | 7.12e-05 | 1.21e-03 | 71 |
GO:00072491 | Colorectum | MSS | I-kappaB kinase/NF-kappaB signaling | 77/3467 | 281/18723 | 1.51e-04 | 2.19e-03 | 77 |
GO:0030178 | Colorectum | MSS | negative regulation of Wnt signaling pathway | 48/3467 | 170/18723 | 1.23e-03 | 1.18e-02 | 48 |
GO:00160553 | Colorectum | FAP | Wnt signaling pathway | 104/2622 | 444/18723 | 4.92e-08 | 3.92e-06 | 104 |
GO:01987383 | Colorectum | FAP | cell-cell signaling by wnt | 104/2622 | 446/18723 | 6.26e-08 | 4.54e-06 | 104 |
GO:00301113 | Colorectum | FAP | regulation of Wnt signaling pathway | 81/2622 | 328/18723 | 1.44e-07 | 9.03e-06 | 81 |
GO:00608283 | Colorectum | FAP | regulation of canonical Wnt signaling pathway | 62/2622 | 253/18723 | 5.26e-06 | 1.69e-04 | 62 |
GO:00600703 | Colorectum | FAP | canonical Wnt signaling pathway | 71/2622 | 303/18723 | 6.23e-06 | 1.96e-04 | 71 |
Page: 1 2 3 4 5 6 7 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04310 | Colorectum | AD | Wnt signaling pathway | 56/2092 | 171/8465 | 1.03e-02 | 3.93e-02 | 2.51e-02 | 56 |
hsa043101 | Colorectum | AD | Wnt signaling pathway | 56/2092 | 171/8465 | 1.03e-02 | 3.93e-02 | 2.51e-02 | 56 |
hsa043102 | Colorectum | MSS | Wnt signaling pathway | 53/1875 | 171/8465 | 4.24e-03 | 1.86e-02 | 1.14e-02 | 53 |
hsa043103 | Colorectum | MSS | Wnt signaling pathway | 53/1875 | 171/8465 | 4.24e-03 | 1.86e-02 | 1.14e-02 | 53 |
hsa043104 | Colorectum | FAP | Wnt signaling pathway | 46/1404 | 171/8465 | 3.94e-04 | 3.06e-03 | 1.86e-03 | 46 |
hsa043105 | Colorectum | FAP | Wnt signaling pathway | 46/1404 | 171/8465 | 3.94e-04 | 3.06e-03 | 1.86e-03 | 46 |
hsa043106 | Colorectum | CRC | Wnt signaling pathway | 40/1091 | 171/8465 | 1.01e-04 | 1.57e-03 | 1.07e-03 | 40 |
hsa043107 | Colorectum | CRC | Wnt signaling pathway | 40/1091 | 171/8465 | 1.01e-04 | 1.57e-03 | 1.07e-03 | 40 |
hsa0431010 | Endometrium | AEH | Wnt signaling pathway | 37/1197 | 171/8465 | 4.68e-03 | 2.53e-02 | 1.86e-02 | 37 |
hsa0431013 | Endometrium | AEH | Wnt signaling pathway | 37/1197 | 171/8465 | 4.68e-03 | 2.53e-02 | 1.86e-02 | 37 |
hsa0431022 | Endometrium | EEC | Wnt signaling pathway | 40/1237 | 171/8465 | 1.37e-03 | 8.99e-03 | 6.70e-03 | 40 |
hsa0431032 | Endometrium | EEC | Wnt signaling pathway | 40/1237 | 171/8465 | 1.37e-03 | 8.99e-03 | 6.70e-03 | 40 |
hsa043306 | Esophagus | ESCC | Notch signaling pathway | 42/4205 | 62/8465 | 2.97e-03 | 7.97e-03 | 4.08e-03 | 42 |
hsa0433013 | Esophagus | ESCC | Notch signaling pathway | 42/4205 | 62/8465 | 2.97e-03 | 7.97e-03 | 4.08e-03 | 42 |
hsa043305 | Oral cavity | OSCC | Notch signaling pathway | 44/3704 | 62/8465 | 1.26e-05 | 5.55e-05 | 2.83e-05 | 44 |
hsa0433012 | Oral cavity | OSCC | Notch signaling pathway | 44/3704 | 62/8465 | 1.26e-05 | 5.55e-05 | 2.83e-05 | 44 |
hsa0433021 | Oral cavity | NEOLP | Notch signaling pathway | 21/1112 | 62/8465 | 2.23e-05 | 1.87e-04 | 1.18e-04 | 21 |
hsa0431024 | Oral cavity | NEOLP | Wnt signaling pathway | 34/1112 | 171/8465 | 8.05e-03 | 2.88e-02 | 1.81e-02 | 34 |
hsa0433031 | Oral cavity | NEOLP | Notch signaling pathway | 21/1112 | 62/8465 | 2.23e-05 | 1.87e-04 | 1.18e-04 | 21 |
hsa0431034 | Oral cavity | NEOLP | Wnt signaling pathway | 34/1112 | 171/8465 | 8.05e-03 | 2.88e-02 | 1.81e-02 | 34 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TLE1 | deletion | Frame_Shift_Del | novel | c.1945delN | p.Arg649GlyfsTer38 | p.R649Gfs*38 | Q04724 | protein_coding | TCGA-EY-A1GT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unspecific | Carboplatin | SD | ||
TLE1 | SNV | Missense_Mutation | c.130A>G | p.Lys44Glu | p.K44E | Q04724 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-G3-A3CK-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TLE1 | SNV | Missense_Mutation | novel | c.1459G>A | p.Val487Met | p.V487M | Q04724 | protein_coding | deleterious(0.01) | possibly_damaging(0.595) | TCGA-55-7911-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TLE1 | SNV | Missense_Mutation | c.1122N>T | p.Met374Ile | p.M374I | Q04724 | protein_coding | tolerated(0.18) | benign(0) | TCGA-55-8203-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TLE1 | SNV | Missense_Mutation | c.347N>A | p.Met116Lys | p.M116K | Q04724 | protein_coding | deleterious(0) | benign(0.428) | TCGA-78-7153-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TLE1 | SNV | Missense_Mutation | c.2260A>G | p.Ile754Val | p.I754V | Q04724 | protein_coding | deleterious(0.03) | probably_damaging(0.923) | TCGA-22-4613-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TLE1 | SNV | Missense_Mutation | novel | c.532N>T | p.Ala178Ser | p.A178S | Q04724 | protein_coding | tolerated(0.17) | benign(0.007) | TCGA-37-4132-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TLE1 | SNV | Missense_Mutation | c.526C>T | p.His176Tyr | p.H176Y | Q04724 | protein_coding | tolerated(0.06) | possibly_damaging(0.506) | TCGA-37-5819-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
TLE1 | SNV | Missense_Mutation | novel | c.1912N>C | p.Asn638His | p.N638H | Q04724 | protein_coding | deleterious(0.01) | possibly_damaging(0.636) | TCGA-43-7657-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TLE1 | SNV | Missense_Mutation | c.1852G>C | p.Gly618Arg | p.G618R | Q04724 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-60-2708-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
Page: 1 2 3 4 5 6 7 8 9 10 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |