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Gene: TAGAP |
Gene summary for TAGAP |
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Gene information | Species | Human | Gene symbol | TAGAP | Gene ID | 117289 |
Gene name | T cell activation RhoGTPase activating protein | |
Gene Alias | ARHGAP47 | |
Cytomap | 6q25.3 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q8N103 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
117289 | TAGAP | GSM5353216_PA_PB1A_Pool_1_3_S50_L002 | Human | Prostate | Tumor | 1.29e-04 | 6.42e-01 | 0.159 |
117289 | TAGAP | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 1.53e-03 | 2.85e-01 | 0.1633 |
117289 | TAGAP | GSM5353224_PA_PR5186_Pool_1_2_3_S27_L001 | Human | Prostate | Tumor | 1.89e-05 | 3.75e-01 | 0.1621 |
117289 | TAGAP | GSM5353226_PA_PR5196-2_Pool_1_2_3_S54_L002 | Human | Prostate | Tumor | 2.91e-04 | 6.30e-01 | 0.159 |
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Tissue | Expression Dynamics | Abbreviation |
Prostate | ![]() | BPH: Benign Prostatic Hyperplasia |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005105613 | Prostate | Tumor | regulation of small GTPase mediated signal transduction | 80/3246 | 302/18723 | 3.96e-05 | 4.57e-04 | 80 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TAGAP | SNV | Missense_Mutation | novel | c.1833N>C | p.Glu611Asp | p.E611D | Q8N103 | protein_coding | tolerated(0.44) | benign(0.015) | TCGA-77-7141-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TAGAP | SNV | Missense_Mutation | novel | c.1021G>A | p.Gly341Ser | p.G341S | Q8N103 | protein_coding | tolerated(0.52) | benign(0.005) | TCGA-77-8156-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TAGAP | SNV | Missense_Mutation | novel | c.1869N>T | p.Met623Ile | p.M623I | Q8N103 | protein_coding | deleterious(0.01) | benign(0.054) | TCGA-85-8582-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TAGAP | SNV | Missense_Mutation | novel | c.1974N>A | p.His658Gln | p.H658Q | Q8N103 | protein_coding | tolerated(0.6) | benign(0.045) | TCGA-90-7769-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TAGAP | SNV | Missense_Mutation | c.496N>T | p.Pro166Ser | p.P166S | Q8N103 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-90-A4ED-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TAGAP | SNV | Missense_Mutation | rs369625327 | c.1841C>T | p.Thr614Ile | p.T614I | Q8N103 | protein_coding | deleterious(0.02) | benign(0.066) | TCGA-O2-A52V-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TAGAP | SNV | Missense_Mutation | novel | c.829N>G | p.Phe277Val | p.F277V | Q8N103 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-O2-A5IB-01 | Lung | lung squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
TAGAP | insertion | In_Frame_Ins | novel | c.1950_1951insCACGGACTCTCTCCCCTGCCTGAGCGATGGAAACAG | p.Gly650_Ser651insHisGlyLeuSerProLeuProGluArgTrpLysGln | p.G650_S651insHGLSPLPERWKQ | Q8N103 | protein_coding | TCGA-92-7340-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD | ||
TAGAP | SNV | Missense_Mutation | novel | c.1796N>T | p.Ala599Val | p.A599V | Q8N103 | protein_coding | deleterious(0) | possibly_damaging(0.859) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
TAGAP | SNV | Missense_Mutation | rs781342205 | c.986N>C | p.Ser329Thr | p.S329T | Q8N103 | protein_coding | tolerated(0.45) | benign(0.078) | TCGA-B7-5816-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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