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Gene: STK10 |
Gene summary for STK10 |
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Gene information | Species | Human | Gene symbol | STK10 | Gene ID | 6793 |
Gene name | serine/threonine kinase 10 | |
Gene Alias | LOK | |
Cytomap | 5q35.1 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | O94804 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6793 | STK10 | LZE7T | Human | Esophagus | ESCC | 9.10e-03 | 1.26e-01 | 0.0667 |
6793 | STK10 | LZE6T | Human | Esophagus | ESCC | 2.75e-02 | 1.40e-01 | 0.0845 |
6793 | STK10 | P1T-E | Human | Esophagus | ESCC | 1.98e-02 | 1.90e-01 | 0.0875 |
6793 | STK10 | P2T-E | Human | Esophagus | ESCC | 3.04e-02 | 4.46e-02 | 0.1177 |
6793 | STK10 | P4T-E | Human | Esophagus | ESCC | 1.31e-03 | 6.92e-02 | 0.1323 |
6793 | STK10 | P5T-E | Human | Esophagus | ESCC | 7.05e-15 | 2.96e-01 | 0.1327 |
6793 | STK10 | P8T-E | Human | Esophagus | ESCC | 4.39e-04 | 1.81e-02 | 0.0889 |
6793 | STK10 | P11T-E | Human | Esophagus | ESCC | 5.52e-07 | 4.33e-01 | 0.1426 |
6793 | STK10 | P12T-E | Human | Esophagus | ESCC | 1.68e-07 | 7.13e-02 | 0.1122 |
6793 | STK10 | P15T-E | Human | Esophagus | ESCC | 7.54e-03 | 9.64e-02 | 0.1149 |
6793 | STK10 | P17T-E | Human | Esophagus | ESCC | 3.82e-07 | 2.21e-01 | 0.1278 |
6793 | STK10 | P20T-E | Human | Esophagus | ESCC | 1.85e-07 | 7.55e-02 | 0.1124 |
6793 | STK10 | P21T-E | Human | Esophagus | ESCC | 8.65e-09 | 1.96e-01 | 0.1617 |
6793 | STK10 | P22T-E | Human | Esophagus | ESCC | 3.43e-03 | 3.52e-02 | 0.1236 |
6793 | STK10 | P23T-E | Human | Esophagus | ESCC | 4.22e-08 | 2.10e-01 | 0.108 |
6793 | STK10 | P24T-E | Human | Esophagus | ESCC | 2.63e-08 | 1.53e-01 | 0.1287 |
6793 | STK10 | P26T-E | Human | Esophagus | ESCC | 1.39e-03 | 6.40e-02 | 0.1276 |
6793 | STK10 | P27T-E | Human | Esophagus | ESCC | 4.45e-05 | 8.83e-02 | 0.1055 |
6793 | STK10 | P28T-E | Human | Esophagus | ESCC | 1.18e-12 | 1.80e-01 | 0.1149 |
6793 | STK10 | P30T-E | Human | Esophagus | ESCC | 3.90e-03 | 2.10e-01 | 0.137 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004677710 | Esophagus | ESCC | protein autophosphorylation | 138/8552 | 227/18723 | 2.98e-06 | 3.38e-05 | 138 |
GO:000268515 | Esophagus | ESCC | regulation of leukocyte migration | 114/8552 | 210/18723 | 7.26e-03 | 2.63e-02 | 114 |
GO:000715918 | Esophagus | ESCC | leukocyte cell-cell adhesion | 192/8552 | 371/18723 | 1.03e-02 | 3.51e-02 | 192 |
GO:00467775 | Liver | HCC | protein autophosphorylation | 123/7958 | 227/18723 | 2.40e-04 | 1.80e-03 | 123 |
GO:00467779 | Oral cavity | OSCC | protein autophosphorylation | 123/7305 | 227/18723 | 2.31e-06 | 2.93e-05 | 123 |
GO:000268510 | Oral cavity | OSCC | regulation of leukocyte migration | 108/7305 | 210/18723 | 1.63e-04 | 1.13e-03 | 108 |
GO:000715916 | Oral cavity | OSCC | leukocyte cell-cell adhesion | 178/7305 | 371/18723 | 2.44e-04 | 1.57e-03 | 178 |
GO:005090010 | Oral cavity | OSCC | leukocyte migration | 176/7305 | 369/18723 | 3.80e-04 | 2.31e-03 | 176 |
GO:00716758 | Oral cavity | OSCC | regulation of mononuclear cell migration | 60/7305 | 115/18723 | 2.78e-03 | 1.21e-02 | 60 |
GO:20004013 | Oral cavity | OSCC | regulation of lymphocyte migration | 34/7305 | 61/18723 | 5.90e-03 | 2.25e-02 | 34 |
GO:000715917 | Oral cavity | EOLP | leukocyte cell-cell adhesion | 86/2218 | 371/18723 | 5.01e-10 | 4.11e-08 | 86 |
GO:005090014 | Oral cavity | EOLP | leukocyte migration | 74/2218 | 369/18723 | 3.40e-06 | 7.35e-05 | 74 |
GO:004677713 | Oral cavity | EOLP | protein autophosphorylation | 49/2218 | 227/18723 | 2.04e-05 | 3.21e-04 | 49 |
GO:00704862 | Oral cavity | EOLP | leukocyte aggregation | 6/2218 | 13/18723 | 2.24e-03 | 1.39e-02 | 6 |
GO:000268514 | Oral cavity | EOLP | regulation of leukocyte migration | 38/2218 | 210/18723 | 5.04e-03 | 2.65e-02 | 38 |
GO:000715923 | Oral cavity | NEOLP | leukocyte cell-cell adhesion | 70/2005 | 371/18723 | 1.65e-06 | 4.05e-05 | 70 |
GO:005090023 | Oral cavity | NEOLP | leukocyte migration | 67/2005 | 369/18723 | 1.04e-05 | 1.96e-04 | 67 |
GO:004677722 | Oral cavity | NEOLP | protein autophosphorylation | 45/2005 | 227/18723 | 3.28e-05 | 4.87e-04 | 45 |
GO:000268523 | Oral cavity | NEOLP | regulation of leukocyte migration | 40/2005 | 210/18723 | 2.14e-04 | 2.27e-03 | 40 |
GO:007167514 | Oral cavity | NEOLP | regulation of mononuclear cell migration | 24/2005 | 115/18723 | 1.00e-03 | 7.68e-03 | 24 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STK10 | insertion | In_Frame_Ins | novel | c.2024_2025insATC | p.Gln675_Arg676insSer | p.Q675_R676insS | O94804 | protein_coding | TCGA-D1-A0ZP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD | ||
STK10 | SNV | Missense_Mutation | c.730N>T | p.Arg244Trp | p.R244W | O94804 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DD-AAD5-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
STK10 | SNV | Missense_Mutation | rs374049452 | c.1853N>A | p.Arg618His | p.R618H | O94804 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-05-4382-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
STK10 | SNV | Missense_Mutation | novel | c.520G>T | p.Ala174Ser | p.A174S | O94804 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-05-4427-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
STK10 | SNV | Missense_Mutation | c.2700N>T | p.Lys900Asn | p.K900N | O94804 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-44-2657-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
STK10 | SNV | Missense_Mutation | c.307N>T | p.Asp103Tyr | p.D103Y | O94804 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-49-AARN-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
STK10 | SNV | Missense_Mutation | c.2869G>T | p.Ala957Ser | p.A957S | O94804 | protein_coding | tolerated_low_confidence(1) | benign(0.001) | TCGA-86-8054-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | CR | |
STK10 | SNV | Missense_Mutation | rs766523400 | c.1207N>A | p.Gly403Ser | p.G403S | O94804 | protein_coding | tolerated(0.27) | benign(0.005) | TCGA-86-8673-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
STK10 | SNV | Missense_Mutation | c.2586C>A | p.His862Gln | p.H862Q | O94804 | protein_coding | tolerated(0.07) | probably_damaging(1) | TCGA-95-7039-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
STK10 | SNV | Missense_Mutation | novel | c.2645N>T | p.Gln882Leu | p.Q882L | O94804 | protein_coding | deleterious(0.01) | possibly_damaging(0.904) | TCGA-37-4135-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6793 | STK10 | SERINE THREONINE KINASE, KINASE, ENZYME, DRUGGABLE GENOME | inhibitor | 381118815 | ||
6793 | STK10 | SERINE THREONINE KINASE, KINASE, ENZYME, DRUGGABLE GENOME | inhibitor | 178102336 | BOSUTINIB | |
6793 | STK10 | SERINE THREONINE KINASE, KINASE, ENZYME, DRUGGABLE GENOME | inhibitor | HESPERADIN | HESPERADIN | 19035792 |
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