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Gene: STIM2 |
Gene summary for STIM2 |
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Gene information | Species | Human | Gene symbol | STIM2 | Gene ID | 57620 |
Gene name | stromal interaction molecule 2 | |
Gene Alias | STIM2 | |
Cytomap | 4p15.2 | |
Gene Type | protein-coding | GO ID | GO:0002115 | UniProtAcc | B3KUB5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57620 | STIM2 | LZE7T | Human | Esophagus | ESCC | 2.39e-05 | 1.55e-01 | 0.0667 |
57620 | STIM2 | LZE8T | Human | Esophagus | ESCC | 3.39e-08 | 1.57e-01 | 0.067 |
57620 | STIM2 | LZE24T | Human | Esophagus | ESCC | 8.25e-05 | 1.70e-01 | 0.0596 |
57620 | STIM2 | LZE21T | Human | Esophagus | ESCC | 1.42e-05 | 1.54e-01 | 0.0655 |
57620 | STIM2 | LZE6T | Human | Esophagus | ESCC | 2.27e-02 | 4.62e-02 | 0.0845 |
57620 | STIM2 | P1T-E | Human | Esophagus | ESCC | 9.78e-05 | 1.83e-01 | 0.0875 |
57620 | STIM2 | P2T-E | Human | Esophagus | ESCC | 4.69e-32 | 5.89e-01 | 0.1177 |
57620 | STIM2 | P4T-E | Human | Esophagus | ESCC | 5.33e-05 | 1.07e-01 | 0.1323 |
57620 | STIM2 | P5T-E | Human | Esophagus | ESCC | 3.08e-08 | 4.71e-02 | 0.1327 |
57620 | STIM2 | P8T-E | Human | Esophagus | ESCC | 5.31e-18 | 3.23e-01 | 0.0889 |
57620 | STIM2 | P9T-E | Human | Esophagus | ESCC | 2.06e-10 | 1.19e-01 | 0.1131 |
57620 | STIM2 | P10T-E | Human | Esophagus | ESCC | 6.82e-25 | 4.84e-01 | 0.116 |
57620 | STIM2 | P11T-E | Human | Esophagus | ESCC | 4.42e-06 | 1.31e-01 | 0.1426 |
57620 | STIM2 | P12T-E | Human | Esophagus | ESCC | 9.24e-06 | 2.48e-01 | 0.1122 |
57620 | STIM2 | P15T-E | Human | Esophagus | ESCC | 4.40e-22 | 3.19e-01 | 0.1149 |
57620 | STIM2 | P16T-E | Human | Esophagus | ESCC | 9.47e-11 | 1.42e-01 | 0.1153 |
57620 | STIM2 | P20T-E | Human | Esophagus | ESCC | 1.42e-05 | 1.91e-01 | 0.1124 |
57620 | STIM2 | P21T-E | Human | Esophagus | ESCC | 6.93e-42 | 1.02e+00 | 0.1617 |
57620 | STIM2 | P22T-E | Human | Esophagus | ESCC | 5.49e-06 | 1.09e-01 | 0.1236 |
57620 | STIM2 | P23T-E | Human | Esophagus | ESCC | 1.15e-10 | 1.52e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00725032 | Oral cavity | EOLP | cellular divalent inorganic cation homeostasis | 75/2218 | 486/18723 | 9.77e-03 | 4.42e-02 | 75 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STIM2 | SNV | Missense_Mutation | novel | c.991G>A | p.Ala331Thr | p.A331T | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-94-8490-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
STIM2 | SNV | Missense_Mutation | novel | c.1214N>G | p.Thr405Ser | p.T405S | protein_coding | tolerated(0.09) | probably_damaging(0.97) | TCGA-NC-A5HT-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | PR | |
STIM2 | deletion | Frame_Shift_Del | novel | c.829_830delNN | p.Arg277LysfsTer16 | p.R277Kfs*16 | protein_coding | TCGA-37-4133-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |||
STIM2 | deletion | Frame_Shift_Del | novel | c.1177delG | p.Glu393LysfsTer22 | p.E393Kfs*22 | protein_coding | TCGA-66-2787-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
STIM2 | SNV | Missense_Mutation | novel | c.1708N>A | p.Leu570Ile | p.L570I | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.978) | TCGA-CN-6010-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD | |
STIM2 | SNV | Missense_Mutation | c.1901N>T | p.Ser634Leu | p.S634L | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.977) | TCGA-CV-5442-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
STIM2 | SNV | Missense_Mutation | novel | c.662N>T | p.Thr221Ile | p.T221I | protein_coding | tolerated(0.5) | benign(0.01) | TCGA-CV-6433-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
STIM2 | SNV | Missense_Mutation | novel | c.908N>A | p.Arg303Gln | p.R303Q | protein_coding | tolerated(0.06) | probably_damaging(0.978) | TCGA-CX-7086-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
STIM2 | SNV | Missense_Mutation | novel | c.1760N>T | p.Ala587Val | p.A587V | protein_coding | tolerated_low_confidence(0.42) | possibly_damaging(0.867) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD | |
STIM2 | insertion | Frame_Shift_Ins | novel | c.224_225insACATAAACAAATGGATGATG | p.Lys83IlefsTer14 | p.K83Ifs*14 | protein_coding | TCGA-J4-A67T-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
57620 | STIM2 | DRUGGABLE GENOME | AMINOGLYCOSIDE ANTIBIOTIC | 17905723 |
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