![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SPOP |
Gene summary for SPOP |
![]() |
Gene information | Species | Human | Gene symbol | SPOP | Gene ID | 8405 |
Gene name | speckle type BTB/POZ protein | |
Gene Alias | BTBD32 | |
Cytomap | 17q21.33 | |
Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | O43791 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8405 | SPOP | LZE4T | Human | Esophagus | ESCC | 7.41e-13 | 4.52e-01 | 0.0811 |
8405 | SPOP | LZE7T | Human | Esophagus | ESCC | 1.13e-05 | 4.31e-01 | 0.0667 |
8405 | SPOP | LZE8T | Human | Esophagus | ESCC | 1.12e-11 | 2.43e-01 | 0.067 |
8405 | SPOP | LZE24T | Human | Esophagus | ESCC | 9.69e-22 | 7.00e-01 | 0.0596 |
8405 | SPOP | P1T-E | Human | Esophagus | ESCC | 6.19e-06 | 2.82e-01 | 0.0875 |
8405 | SPOP | P2T-E | Human | Esophagus | ESCC | 2.81e-35 | 5.80e-01 | 0.1177 |
8405 | SPOP | P4T-E | Human | Esophagus | ESCC | 1.29e-24 | 6.74e-01 | 0.1323 |
8405 | SPOP | P5T-E | Human | Esophagus | ESCC | 4.77e-13 | 3.31e-01 | 0.1327 |
8405 | SPOP | P8T-E | Human | Esophagus | ESCC | 1.81e-29 | 6.47e-01 | 0.0889 |
8405 | SPOP | P9T-E | Human | Esophagus | ESCC | 4.24e-10 | 2.05e-01 | 0.1131 |
8405 | SPOP | P10T-E | Human | Esophagus | ESCC | 5.69e-26 | 5.60e-01 | 0.116 |
8405 | SPOP | P11T-E | Human | Esophagus | ESCC | 1.40e-19 | 8.50e-01 | 0.1426 |
8405 | SPOP | P12T-E | Human | Esophagus | ESCC | 3.97e-33 | 7.15e-01 | 0.1122 |
8405 | SPOP | P15T-E | Human | Esophagus | ESCC | 3.27e-27 | 5.33e-01 | 0.1149 |
8405 | SPOP | P16T-E | Human | Esophagus | ESCC | 2.16e-22 | 5.79e-01 | 0.1153 |
8405 | SPOP | P17T-E | Human | Esophagus | ESCC | 1.16e-08 | 4.76e-01 | 0.1278 |
8405 | SPOP | P19T-E | Human | Esophagus | ESCC | 1.74e-08 | 6.12e-01 | 0.1662 |
8405 | SPOP | P20T-E | Human | Esophagus | ESCC | 2.56e-14 | 5.60e-01 | 0.1124 |
8405 | SPOP | P21T-E | Human | Esophagus | ESCC | 2.81e-24 | 6.28e-01 | 0.1617 |
8405 | SPOP | P22T-E | Human | Esophagus | ESCC | 1.34e-25 | 4.22e-01 | 0.1236 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010498111 | Esophagus | ESCC | proteasomal protein catabolic process | 369/8552 | 490/18723 | 1.13e-41 | 1.80e-38 | 369 |
GO:0043161111 | Esophagus | ESCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 312/8552 | 412/18723 | 3.53e-36 | 4.48e-33 | 312 |
GO:000020917 | Esophagus | ESCC | protein polyubiquitination | 170/8552 | 236/18723 | 1.40e-16 | 1.09e-14 | 170 |
GO:00431617 | Liver | NAFLD | proteasome-mediated ubiquitin-dependent protein catabolic process | 91/1882 | 412/18723 | 3.00e-13 | 1.75e-10 | 91 |
GO:00104987 | Liver | NAFLD | proteasomal protein catabolic process | 101/1882 | 490/18723 | 1.35e-12 | 6.09e-10 | 101 |
GO:00002095 | Liver | NAFLD | protein polyubiquitination | 51/1882 | 236/18723 | 1.04e-07 | 8.10e-06 | 51 |
GO:001049812 | Liver | Cirrhotic | proteasomal protein catabolic process | 216/4634 | 490/18723 | 2.52e-21 | 9.29e-19 | 216 |
GO:004316112 | Liver | Cirrhotic | proteasome-mediated ubiquitin-dependent protein catabolic process | 184/4634 | 412/18723 | 4.52e-19 | 8.85e-17 | 184 |
GO:000020911 | Liver | Cirrhotic | protein polyubiquitination | 89/4634 | 236/18723 | 6.09e-06 | 9.80e-05 | 89 |
GO:001049822 | Liver | HCC | proteasomal protein catabolic process | 351/7958 | 490/18723 | 6.92e-40 | 1.46e-36 | 351 |
GO:004316122 | Liver | HCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 299/7958 | 412/18723 | 7.82e-36 | 8.27e-33 | 299 |
GO:000020921 | Liver | HCC | protein polyubiquitination | 151/7958 | 236/18723 | 1.90e-11 | 7.59e-10 | 151 |
GO:001049820 | Oral cavity | OSCC | proteasomal protein catabolic process | 336/7305 | 490/18723 | 5.45e-41 | 8.63e-38 | 336 |
GO:004316120 | Oral cavity | OSCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 285/7305 | 412/18723 | 5.68e-36 | 5.99e-33 | 285 |
GO:000020910 | Oral cavity | OSCC | protein polyubiquitination | 150/7305 | 236/18723 | 1.59e-14 | 9.27e-13 | 150 |
GO:0010498110 | Oral cavity | LP | proteasomal protein catabolic process | 224/4623 | 490/18723 | 9.57e-25 | 4.00e-22 | 224 |
GO:0043161110 | Oral cavity | LP | proteasome-mediated ubiquitin-dependent protein catabolic process | 190/4623 | 412/18723 | 1.08e-21 | 2.93e-19 | 190 |
GO:000020915 | Oral cavity | LP | protein polyubiquitination | 82/4623 | 236/18723 | 3.23e-04 | 3.26e-03 | 82 |
GO:001049828 | Skin | cSCC | proteasomal protein catabolic process | 243/4864 | 490/18723 | 7.85e-30 | 4.10e-27 | 243 |
GO:004316128 | Skin | cSCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 205/4864 | 412/18723 | 1.46e-25 | 4.16e-23 | 205 |
Page: 1 2 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SPOP | SNV | Missense_Mutation | c.1067N>A | p.Leu356Gln | p.L356Q | O43791 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-DD-A113-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
SPOP | SNV | Missense_Mutation | c.980N>G | p.Tyr327Cys | p.Y327C | O43791 | protein_coding | tolerated(0.18) | benign(0.001) | TCGA-UB-A7MB-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Targeted Molecular therapy | sorafenib | PD | |
SPOP | SNV | Missense_Mutation | c.103N>T | p.Met35Leu | p.M35L | O43791 | protein_coding | tolerated(0.38) | benign(0) | TCGA-UB-A7MB-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Targeted Molecular therapy | sorafenib | PD | |
SPOP | SNV | Missense_Mutation | c.224G>T | p.Gly75Val | p.G75V | O43791 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-35-5375-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
SPOP | SNV | Missense_Mutation | c.223G>T | p.Gly75Trp | p.G75W | O43791 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-35-5375-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
SPOP | SNV | Missense_Mutation | c.575N>C | p.Gly192Ala | p.G192A | O43791 | protein_coding | tolerated(0.47) | benign(0.009) | TCGA-55-8203-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SPOP | SNV | Missense_Mutation | novel | c.536T>G | p.Val179Gly | p.V179G | O43791 | protein_coding | deleterious(0.01) | possibly_damaging(0.89) | TCGA-67-6216-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SPOP | SNV | Missense_Mutation | novel | c.394N>A | p.Gly132Arg | p.G132R | O43791 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-85-8072-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SPOP | SNV | Missense_Mutation | novel | c.841N>T | p.Ala281Ser | p.A281S | O43791 | protein_coding | tolerated(0.05) | possibly_damaging(0.473) | TCGA-CV-7438-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SPOP | SNV | Missense_Mutation | novel | c.733N>A | p.Asp245Asn | p.D245N | O43791 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-QK-A8Z8-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | PD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |