![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SP110 |
Gene summary for SP110 |
![]() |
Gene information | Species | Human | Gene symbol | SP110 | Gene ID | 3431 |
Gene name | SP110 nuclear body protein | |
Gene Alias | IFI41 | |
Cytomap | 2q37.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9HB58 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3431 | SP110 | LZE4T | Human | Esophagus | ESCC | 3.47e-14 | 4.85e-01 | 0.0811 |
3431 | SP110 | LZE5T | Human | Esophagus | ESCC | 1.92e-04 | 3.33e-01 | 0.0514 |
3431 | SP110 | LZE7T | Human | Esophagus | ESCC | 1.97e-05 | 2.37e-01 | 0.0667 |
3431 | SP110 | LZE8T | Human | Esophagus | ESCC | 1.19e-03 | 1.82e-01 | 0.067 |
3431 | SP110 | LZE20T | Human | Esophagus | ESCC | 5.71e-14 | 3.98e-01 | 0.0662 |
3431 | SP110 | LZE22D1 | Human | Esophagus | HGIN | 1.91e-04 | 2.26e-01 | 0.0595 |
3431 | SP110 | LZE22T | Human | Esophagus | ESCC | 8.97e-03 | 2.51e-01 | 0.068 |
3431 | SP110 | LZE24T | Human | Esophagus | ESCC | 7.62e-33 | 1.09e+00 | 0.0596 |
3431 | SP110 | LZE21T | Human | Esophagus | ESCC | 5.27e-04 | 3.36e-01 | 0.0655 |
3431 | SP110 | LZE6T | Human | Esophagus | ESCC | 1.43e-07 | 4.61e-01 | 0.0845 |
3431 | SP110 | P1T-E | Human | Esophagus | ESCC | 6.84e-05 | 4.96e-01 | 0.0875 |
3431 | SP110 | P2T-E | Human | Esophagus | ESCC | 1.06e-27 | 5.12e-01 | 0.1177 |
3431 | SP110 | P4T-E | Human | Esophagus | ESCC | 5.90e-05 | 1.86e-01 | 0.1323 |
3431 | SP110 | P5T-E | Human | Esophagus | ESCC | 1.70e-08 | 1.74e-01 | 0.1327 |
3431 | SP110 | P8T-E | Human | Esophagus | ESCC | 9.66e-27 | 4.73e-01 | 0.0889 |
3431 | SP110 | P9T-E | Human | Esophagus | ESCC | 6.08e-17 | 4.65e-01 | 0.1131 |
3431 | SP110 | P10T-E | Human | Esophagus | ESCC | 2.17e-05 | 5.32e-02 | 0.116 |
3431 | SP110 | P11T-E | Human | Esophagus | ESCC | 4.12e-26 | 9.96e-01 | 0.1426 |
3431 | SP110 | P12T-E | Human | Esophagus | ESCC | 4.31e-12 | 2.28e-01 | 0.1122 |
3431 | SP110 | P15T-E | Human | Esophagus | ESCC | 1.62e-15 | 3.76e-01 | 0.1149 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SP110 | SNV | Missense_Mutation | rs556856317 | c.1268N>T | p.Ser423Phe | p.S423F | Q9HB58 | protein_coding | deleterious(0.04) | possibly_damaging(0.552) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
SP110 | SNV | Missense_Mutation | rs200816727 | c.670N>A | p.Ala224Thr | p.A224T | Q9HB58 | protein_coding | tolerated(0.5) | benign(0.006) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
SP110 | SNV | Missense_Mutation | c.1550N>G | p.Asn517Ser | p.N517S | Q9HB58 | protein_coding | tolerated(1) | benign(0.001) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
SP110 | SNV | Missense_Mutation | novel | c.1858N>G | p.Ser620Gly | p.S620G | Q9HB58 | protein_coding | tolerated(0.05) | benign(0.055) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SP110 | SNV | Missense_Mutation | c.1528N>G | p.Asn510Asp | p.N510D | Q9HB58 | protein_coding | tolerated(0.26) | benign(0.001) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SP110 | SNV | Missense_Mutation | rs765616523 | c.1555C>T | p.Arg519Cys | p.R519C | Q9HB58 | protein_coding | tolerated(0.18) | benign(0.045) | TCGA-BR-6852-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SP110 | SNV | Missense_Mutation | rs745817983 | c.1531N>A | p.Ala511Thr | p.A511T | Q9HB58 | protein_coding | tolerated(0.25) | benign(0) | TCGA-BR-7707-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SP110 | SNV | Missense_Mutation | rs140285393 | c.1556N>A | p.Arg519His | p.R519H | Q9HB58 | protein_coding | tolerated(0.64) | benign(0.009) | TCGA-BR-8081-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SP110 | SNV | Missense_Mutation | c.25N>A | p.Glu9Lys | p.E9K | Q9HB58 | protein_coding | tolerated(0.17) | benign(0.144) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
SP110 | SNV | Missense_Mutation | rs114017623 | c.413C>T | p.Ala138Val | p.A138V | Q9HB58 | protein_coding | tolerated(0.26) | benign(0.107) | TCGA-CD-8527-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | epirubicin | PD |
Page: 1 2 3 4 5 6 7 8 9 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |