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Gene: SOX6 |
Gene summary for SOX6 |
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Gene information | Species | Human | Gene symbol | SOX6 | Gene ID | 55553 |
Gene name | SRY-box transcription factor 6 | |
Gene Alias | HSSOX6 | |
Cytomap | 11p15.2 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | P35712 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55553 | SOX6 | CCI_2 | Human | Cervix | CC | 1.84e-02 | 1.07e+00 | 0.5249 |
55553 | SOX6 | CCI_3 | Human | Cervix | CC | 1.63e-09 | 8.12e-01 | 0.516 |
55553 | SOX6 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.09e-03 | 2.47e-01 | -0.1954 |
55553 | SOX6 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.46e-03 | 1.58e-01 | -0.1464 |
55553 | SOX6 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.40e-02 | 1.51e-01 | -0.1001 |
55553 | SOX6 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.11e-12 | 1.46e+00 | 0.3487 |
55553 | SOX6 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.18e-03 | 3.60e-01 | 0.281 |
55553 | SOX6 | CRC-1-8810 | Human | Colorectum | CRC | 1.99e-09 | 4.83e-01 | 0.6257 |
55553 | SOX6 | CRC-3-11773 | Human | Colorectum | CRC | 1.21e-03 | 3.72e-01 | 0.2564 |
55553 | SOX6 | AEH-subject1 | Human | Endometrium | AEH | 9.38e-39 | 8.63e-01 | -0.3059 |
55553 | SOX6 | AEH-subject2 | Human | Endometrium | AEH | 2.60e-13 | 5.77e-01 | -0.2525 |
55553 | SOX6 | AEH-subject3 | Human | Endometrium | AEH | 5.69e-28 | 7.69e-01 | -0.2576 |
55553 | SOX6 | AEH-subject4 | Human | Endometrium | AEH | 7.92e-33 | 9.37e-01 | -0.2657 |
55553 | SOX6 | AEH-subject5 | Human | Endometrium | AEH | 2.28e-59 | 1.16e+00 | -0.2953 |
55553 | SOX6 | EEC-subject1 | Human | Endometrium | EEC | 1.49e-13 | 4.60e-01 | -0.2682 |
55553 | SOX6 | EEC-subject2 | Human | Endometrium | EEC | 6.60e-48 | 9.53e-01 | -0.2607 |
55553 | SOX6 | EEC-subject4 | Human | Endometrium | EEC | 3.86e-24 | 6.98e-01 | -0.2571 |
55553 | SOX6 | EEC-subject5 | Human | Endometrium | EEC | 2.20e-29 | 8.05e-01 | -0.249 |
55553 | SOX6 | GSM5276935 | Human | Endometrium | EEC | 2.19e-02 | 1.97e-01 | -0.123 |
55553 | SOX6 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 1.74e-11 | 3.07e-01 | -0.1917 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:20007362 | Cervix | CC | regulation of stem cell differentiation | 19/2311 | 58/18723 | 4.01e-05 | 6.21e-04 | 19 |
GO:00488634 | Cervix | CC | stem cell differentiation | 46/2311 | 206/18723 | 4.11e-05 | 6.36e-04 | 46 |
GO:00605375 | Cervix | CC | muscle tissue development | 76/2311 | 403/18723 | 9.76e-05 | 1.27e-03 | 76 |
GO:00147064 | Cervix | CC | striated muscle tissue development | 72/2311 | 384/18723 | 1.76e-04 | 2.07e-03 | 72 |
GO:00715595 | Cervix | CC | response to transforming growth factor beta | 50/2311 | 256/18723 | 6.31e-04 | 5.91e-03 | 50 |
GO:00715605 | Cervix | CC | cellular response to transforming growth factor beta stimulus | 49/2311 | 250/18723 | 6.55e-04 | 6.05e-03 | 49 |
GO:00426924 | Cervix | CC | muscle cell differentiation | 69/2311 | 384/18723 | 8.12e-04 | 7.09e-03 | 69 |
GO:00075173 | Cervix | CC | muscle organ development | 58/2311 | 327/18723 | 2.73e-03 | 1.85e-02 | 58 |
GO:00511464 | Cervix | CC | striated muscle cell differentiation | 50/2311 | 283/18723 | 5.53e-03 | 3.19e-02 | 50 |
GO:0071559 | Colorectum | AD | response to transforming growth factor beta | 74/3918 | 256/18723 | 1.45e-03 | 1.23e-02 | 74 |
GO:0071560 | Colorectum | AD | cellular response to transforming growth factor beta stimulus | 72/3918 | 250/18723 | 1.85e-03 | 1.52e-02 | 72 |
GO:00715592 | Colorectum | CRC | response to transforming growth factor beta | 51/2078 | 256/18723 | 2.33e-05 | 6.65e-04 | 51 |
GO:00715602 | Colorectum | CRC | cellular response to transforming growth factor beta stimulus | 49/2078 | 250/18723 | 5.17e-05 | 1.19e-03 | 49 |
GO:00488631 | Colorectum | CRC | stem cell differentiation | 39/2078 | 206/18723 | 5.89e-04 | 7.89e-03 | 39 |
GO:0060537 | Colorectum | CRC | muscle tissue development | 63/2078 | 403/18723 | 3.17e-03 | 2.78e-02 | 63 |
GO:0002062 | Colorectum | CRC | chondrocyte differentiation | 21/2078 | 106/18723 | 5.87e-03 | 4.33e-02 | 21 |
GO:0014706 | Colorectum | CRC | striated muscle tissue development | 59/2078 | 384/18723 | 6.11e-03 | 4.47e-02 | 59 |
GO:0048705 | Colorectum | CRC | skeletal system morphogenesis | 37/2078 | 220/18723 | 6.58e-03 | 4.71e-02 | 37 |
GO:00605376 | Endometrium | AEH | muscle tissue development | 83/2100 | 403/18723 | 2.57e-08 | 1.50e-06 | 83 |
GO:00147065 | Endometrium | AEH | striated muscle tissue development | 75/2100 | 384/18723 | 1.06e-06 | 3.62e-05 | 75 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SOX6 | SNV | Missense_Mutation | novel | c.612G>T | p.Gln204His | p.Q204H | P35712 | protein_coding | deleterious(0.01) | probably_damaging(0.946) | TCGA-44-7662-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SOX6 | SNV | Missense_Mutation | c.1465N>G | p.Leu489Val | p.L489V | P35712 | protein_coding | deleterious(0.04) | benign(0.431) | TCGA-44-A47A-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SOX6 | SNV | Missense_Mutation | c.916N>A | p.Gln306Lys | p.Q306K | P35712 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-55-7994-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR | |
SOX6 | SNV | Missense_Mutation | rs745532158 | c.913N>A | p.Val305Ile | p.V305I | P35712 | protein_coding | deleterious(0.02) | benign(0.31) | TCGA-55-8302-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SOX6 | SNV | Missense_Mutation | c.1289G>C | p.Arg430Pro | p.R430P | P35712 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-73-4666-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | |
SOX6 | SNV | Missense_Mutation | c.570N>T | p.Gln190His | p.Q190H | P35712 | protein_coding | deleterious(0.02) | benign(0.045) | TCGA-78-7156-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
SOX6 | SNV | Missense_Mutation | c.2127N>T | p.Gln709His | p.Q709H | P35712 | protein_coding | tolerated(0.08) | probably_damaging(0.946) | TCGA-86-8073-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SOX6 | SNV | Missense_Mutation | c.1435G>C | p.Asp479His | p.D479H | P35712 | protein_coding | deleterious(0) | probably_damaging(0.946) | TCGA-86-A4D0-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | etoposide | CR | |
SOX6 | SNV | Missense_Mutation | c.956N>A | p.Gly319Glu | p.G319E | P35712 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-93-8067-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SOX6 | SNV | Missense_Mutation | novel | c.1229C>A | p.Thr410Asn | p.T410N | P35712 | protein_coding | tolerated(0.43) | benign(0.311) | TCGA-L4-A4E5-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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