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Gene: SLC9A1 |
Gene summary for SLC9A1 |
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Gene information | Species | Human | Gene symbol | SLC9A1 | Gene ID | 6548 |
Gene name | solute carrier family 9 member A1 | |
Gene Alias | APNH | |
Cytomap | 1p36.11 | |
Gene Type | protein-coding | GO ID | GO:0001508 | UniProtAcc | B2RAH2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6548 | SLC9A1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.88e-13 | 6.35e-01 | -0.1808 |
6548 | SLC9A1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.72e-07 | 3.64e-01 | -0.0811 |
6548 | SLC9A1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.06e-18 | 6.47e-01 | -0.1954 |
6548 | SLC9A1 | HTA11_411_2000001011 | Human | Colorectum | SER | 9.31e-03 | 8.29e-01 | -0.2602 |
6548 | SLC9A1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.23e-02 | 7.25e-01 | -0.2196 |
6548 | SLC9A1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.80e-06 | 5.56e-01 | -0.1207 |
6548 | SLC9A1 | HTA11_83_2000001011 | Human | Colorectum | SER | 6.12e-05 | 5.17e-01 | -0.1526 |
6548 | SLC9A1 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.44e-14 | 7.66e-01 | -0.1464 |
6548 | SLC9A1 | HTA11_866_2000001011 | Human | Colorectum | AD | 9.65e-03 | 2.88e-01 | -0.1001 |
6548 | SLC9A1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.84e-07 | 5.16e-01 | -0.059 |
6548 | SLC9A1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.93e-04 | 6.05e-01 | -0.2061 |
6548 | SLC9A1 | A015-C-203 | Human | Colorectum | FAP | 4.96e-03 | -1.14e-01 | -0.1294 |
6548 | SLC9A1 | A002-C-205 | Human | Colorectum | FAP | 1.88e-03 | -2.02e-01 | -0.1236 |
6548 | SLC9A1 | A015-C-104 | Human | Colorectum | FAP | 4.47e-08 | -2.17e-01 | -0.1899 |
6548 | SLC9A1 | A001-C-014 | Human | Colorectum | FAP | 1.98e-02 | -1.40e-01 | 0.0135 |
6548 | SLC9A1 | CRC-1-8810 | Human | Colorectum | CRC | 3.16e-03 | -1.69e-01 | 0.6257 |
6548 | SLC9A1 | LZE7T | Human | Esophagus | ESCC | 1.80e-03 | 1.43e-01 | 0.0667 |
6548 | SLC9A1 | LZE20T | Human | Esophagus | ESCC | 2.44e-07 | 1.54e-01 | 0.0662 |
6548 | SLC9A1 | LZE24T | Human | Esophagus | ESCC | 2.29e-10 | 2.39e-01 | 0.0596 |
6548 | SLC9A1 | P1T-E | Human | Esophagus | ESCC | 2.69e-04 | 3.52e-01 | 0.0875 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007015 | Colorectum | AD | actin filament organization | 167/3918 | 442/18723 | 1.65e-16 | 7.94e-14 | 167 |
GO:0006839 | Colorectum | AD | mitochondrial transport | 102/3918 | 254/18723 | 1.87e-12 | 3.08e-10 | 102 |
GO:1902903 | Colorectum | AD | regulation of supramolecular fiber organization | 139/3918 | 383/18723 | 2.01e-12 | 3.19e-10 | 139 |
GO:0032970 | Colorectum | AD | regulation of actin filament-based process | 142/3918 | 397/18723 | 4.05e-12 | 5.90e-10 | 142 |
GO:0110053 | Colorectum | AD | regulation of actin filament organization | 108/3918 | 278/18723 | 5.02e-12 | 6.98e-10 | 108 |
GO:0032956 | Colorectum | AD | regulation of actin cytoskeleton organization | 127/3918 | 358/18723 | 1.03e-10 | 1.04e-08 | 127 |
GO:1902600 | Colorectum | AD | proton transmembrane transport | 66/3918 | 157/18723 | 1.59e-09 | 1.17e-07 | 66 |
GO:0034329 | Colorectum | AD | cell junction assembly | 136/3918 | 420/18723 | 2.02e-08 | 1.15e-06 | 136 |
GO:0010810 | Colorectum | AD | regulation of cell-substrate adhesion | 81/3918 | 221/18723 | 4.80e-08 | 2.55e-06 | 81 |
GO:0032868 | Colorectum | AD | response to insulin | 91/3918 | 264/18723 | 2.02e-07 | 8.48e-06 | 91 |
GO:0150115 | Colorectum | AD | cell-substrate junction organization | 44/3918 | 101/18723 | 2.38e-07 | 9.81e-06 | 44 |
GO:0007006 | Colorectum | AD | mitochondrial membrane organization | 48/3918 | 116/18723 | 4.53e-07 | 1.72e-05 | 48 |
GO:0031589 | Colorectum | AD | cell-substrate adhesion | 116/3918 | 363/18723 | 4.68e-07 | 1.76e-05 | 116 |
GO:0007163 | Colorectum | AD | establishment or maintenance of cell polarity | 77/3918 | 218/18723 | 5.72e-07 | 2.08e-05 | 77 |
GO:0007044 | Colorectum | AD | cell-substrate junction assembly | 41/3918 | 95/18723 | 8.20e-07 | 2.85e-05 | 41 |
GO:1901653 | Colorectum | AD | cellular response to peptide | 114/3918 | 359/18723 | 8.32e-07 | 2.88e-05 | 114 |
GO:0032869 | Colorectum | AD | cellular response to insulin stimulus | 72/3918 | 203/18723 | 1.10e-06 | 3.68e-05 | 72 |
GO:0070997 | Colorectum | AD | neuron death | 114/3918 | 361/18723 | 1.13e-06 | 3.72e-05 | 114 |
GO:0061572 | Colorectum | AD | actin filament bundle organization | 60/3918 | 161/18723 | 1.33e-06 | 4.23e-05 | 60 |
GO:0071375 | Colorectum | AD | cellular response to peptide hormone stimulus | 95/3918 | 290/18723 | 1.50e-06 | 4.66e-05 | 95 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04919 | Colorectum | AD | Thyroid hormone signaling pathway | 51/2092 | 121/8465 | 1.71e-05 | 1.73e-04 | 1.10e-04 | 51 |
hsa05205 | Colorectum | AD | Proteoglycans in cancer | 70/2092 | 205/8465 | 1.37e-03 | 8.46e-03 | 5.39e-03 | 70 |
hsa04810 | Colorectum | AD | Regulation of actin cytoskeleton | 75/2092 | 229/8465 | 3.36e-03 | 1.76e-02 | 1.12e-02 | 75 |
hsa04971 | Colorectum | AD | Gastric acid secretion | 29/2092 | 76/8465 | 6.25e-03 | 2.68e-02 | 1.71e-02 | 29 |
hsa04260 | Colorectum | AD | Cardiac muscle contraction | 32/2092 | 87/8465 | 7.92e-03 | 3.13e-02 | 2.00e-02 | 32 |
hsa04972 | Colorectum | AD | Pancreatic secretion | 36/2092 | 102/8465 | 1.06e-02 | 3.98e-02 | 2.54e-02 | 36 |
hsa049191 | Colorectum | AD | Thyroid hormone signaling pathway | 51/2092 | 121/8465 | 1.71e-05 | 1.73e-04 | 1.10e-04 | 51 |
hsa052051 | Colorectum | AD | Proteoglycans in cancer | 70/2092 | 205/8465 | 1.37e-03 | 8.46e-03 | 5.39e-03 | 70 |
hsa048101 | Colorectum | AD | Regulation of actin cytoskeleton | 75/2092 | 229/8465 | 3.36e-03 | 1.76e-02 | 1.12e-02 | 75 |
hsa049711 | Colorectum | AD | Gastric acid secretion | 29/2092 | 76/8465 | 6.25e-03 | 2.68e-02 | 1.71e-02 | 29 |
hsa042601 | Colorectum | AD | Cardiac muscle contraction | 32/2092 | 87/8465 | 7.92e-03 | 3.13e-02 | 2.00e-02 | 32 |
hsa049721 | Colorectum | AD | Pancreatic secretion | 36/2092 | 102/8465 | 1.06e-02 | 3.98e-02 | 2.54e-02 | 36 |
hsa049192 | Colorectum | SER | Thyroid hormone signaling pathway | 40/1580 | 121/8465 | 1.02e-04 | 1.06e-03 | 7.67e-04 | 40 |
hsa042602 | Colorectum | SER | Cardiac muscle contraction | 31/1580 | 87/8465 | 1.30e-04 | 1.30e-03 | 9.47e-04 | 31 |
hsa049712 | Colorectum | SER | Gastric acid secretion | 27/1580 | 76/8465 | 3.65e-04 | 3.27e-03 | 2.38e-03 | 27 |
hsa052052 | Colorectum | SER | Proteoglycans in cancer | 58/1580 | 205/8465 | 4.37e-04 | 3.82e-03 | 2.77e-03 | 58 |
hsa048102 | Colorectum | SER | Regulation of actin cytoskeleton | 60/1580 | 229/8465 | 2.74e-03 | 2.02e-02 | 1.47e-02 | 60 |
hsa049722 | Colorectum | SER | Pancreatic secretion | 30/1580 | 102/8465 | 5.41e-03 | 3.28e-02 | 2.38e-02 | 30 |
hsa049193 | Colorectum | SER | Thyroid hormone signaling pathway | 40/1580 | 121/8465 | 1.02e-04 | 1.06e-03 | 7.67e-04 | 40 |
hsa042603 | Colorectum | SER | Cardiac muscle contraction | 31/1580 | 87/8465 | 1.30e-04 | 1.30e-03 | 9.47e-04 | 31 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC9A1 | deletion | Frame_Shift_Del | novel | c.2340delC | p.Ala781ArgfsTer115 | p.A781Rfs*115 | P19634 | protein_coding | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
SLC9A1 | deletion | Frame_Shift_Del | novel | c.850delN | p.Glu284AsnfsTer13 | p.E284Nfs*13 | P19634 | protein_coding | TCGA-IQ-7630-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | docetaxel | CR | ||
SLC9A1 | SNV | Missense_Mutation | rs372651626 | c.2309C>T | p.Ser770Leu | p.S770L | P19634 | protein_coding | tolerated(0.19) | benign(0.028) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
SLC9A1 | SNV | Missense_Mutation | novel | c.386T>A | p.Val129Asp | p.V129D | P19634 | protein_coding | deleterious(0) | possibly_damaging(0.908) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
SLC9A1 | SNV | Missense_Mutation | c.880N>A | p.Gly294Ser | p.G294S | P19634 | protein_coding | deleterious(0.04) | possibly_damaging(0.813) | TCGA-BR-4201-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | SD | |
SLC9A1 | SNV | Missense_Mutation | c.1163G>A | p.Ser388Asn | p.S388N | P19634 | protein_coding | deleterious(0.01) | possibly_damaging(0.702) | TCGA-BR-4369-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SLC9A1 | SNV | Missense_Mutation | c.880N>A | p.Gly294Ser | p.G294S | P19634 | protein_coding | deleterious(0.04) | possibly_damaging(0.813) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC9A1 | SNV | Missense_Mutation | c.1064N>T | p.Ala355Val | p.A355V | P19634 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-BR-6852-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SLC9A1 | SNV | Missense_Mutation | c.1699C>T | p.Arg567Cys | p.R567C | P19634 | protein_coding | deleterious(0.03) | benign(0.106) | TCGA-BR-A4QL-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR | |
SLC9A1 | SNV | Missense_Mutation | c.1680G>C | p.Lys560Asn | p.K560N | P19634 | protein_coding | deleterious(0) | probably_damaging(0.943) | TCGA-CD-A4MJ-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6548 | SLC9A1 | TRANSPORTER, DRUGGABLE GENOME, EXCHANGER, CELL SURFACE | CARIPORIDE | CARIPORIDE | 17493937 | |
6548 | SLC9A1 | TRANSPORTER, DRUGGABLE GENOME, EXCHANGER, CELL SURFACE | Zoniporide hydrochloride | |||
6548 | SLC9A1 | TRANSPORTER, DRUGGABLE GENOME, EXCHANGER, CELL SURFACE | HOE-694 | CHEMBL62231 | 17493937 |
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