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Gene: SLC14A2 |
Gene summary for SLC14A2 |
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Gene information | Species | Human | Gene symbol | SLC14A2 | Gene ID | 8170 |
Gene name | solute carrier family 14 member 2 | |
Gene Alias | HUT2 | |
Cytomap | 18q12.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q15849 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8170 | SLC14A2 | HCC1 | Human | Liver | HCC | 2.28e-17 | 1.50e+00 | 0.5336 |
8170 | SLC14A2 | HCC2 | Human | Liver | HCC | 6.04e-30 | 1.60e+00 | 0.5341 |
8170 | SLC14A2 | HCC5 | Human | Liver | HCC | 1.94e-30 | 1.81e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC14A2 | SNV | Missense_Mutation | c.662N>A | p.Ser221Tyr | p.S221Y | Q15849 | protein_coding | tolerated(0.06) | possibly_damaging(0.642) | TCGA-55-7726-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC14A2 | SNV | Missense_Mutation | c.413G>C | p.Gly138Ala | p.G138A | Q15849 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-55-8203-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC14A2 | SNV | Missense_Mutation | c.1151N>T | p.Ala384Val | p.A384V | Q15849 | protein_coding | tolerated(0.22) | benign(0.125) | TCGA-67-3771-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC14A2 | SNV | Missense_Mutation | novel | c.2746N>C | p.Ala916Pro | p.A916P | Q15849 | protein_coding | tolerated_low_confidence(0.05) | benign(0.439) | TCGA-73-A9RS-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
SLC14A2 | SNV | Missense_Mutation | c.1289N>A | p.Pro430His | p.P430H | Q15849 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-95-7039-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
SLC14A2 | SNV | Missense_Mutation | c.2078N>T | p.Trp693Leu | p.W693L | Q15849 | protein_coding | deleterious(0) | possibly_damaging(0.573) | TCGA-97-7938-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC14A2 | SNV | Missense_Mutation | c.2183N>G | p.Ala728Gly | p.A728G | Q15849 | protein_coding | tolerated(0.19) | benign(0.102) | TCGA-97-A4M3-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SLC14A2 | SNV | Missense_Mutation | c.2695T>A | p.Tyr899Asn | p.Y899N | Q15849 | protein_coding | deleterious(0) | benign(0.379) | TCGA-MP-A4TK-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
SLC14A2 | SNV | Missense_Mutation | c.900G>T | p.Trp300Cys | p.W300C | Q15849 | protein_coding | deleterious(0) | probably_damaging(0.964) | TCGA-18-3415-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | navelbine | CR | |
SLC14A2 | SNV | Missense_Mutation | rs368161253 | c.2752N>A | p.Asp918Asn | p.D918N | Q15849 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.454) | TCGA-21-5782-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8170 | SLC14A2 | TRANSPORTER | nifedipine | NIFEDIPINE | 17344938 |
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