![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SLC13A3 |
Gene summary for SLC13A3 |
![]() |
Gene information | Species | Human | Gene symbol | SLC13A3 | Gene ID | 64849 |
Gene name | solute carrier family 13 member 3 | |
Gene Alias | ARLIAK | |
Cytomap | 20q13.12 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q8WWT9 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64849 | SLC13A3 | HCC1_Meng | Human | Liver | HCC | 2.54e-02 | -2.93e-02 | 0.0246 |
64849 | SLC13A3 | HCC1 | Human | Liver | HCC | 5.89e-22 | 4.50e+00 | 0.5336 |
64849 | SLC13A3 | S014 | Human | Liver | HCC | 7.28e-55 | 2.24e+00 | 0.2254 |
64849 | SLC13A3 | S015 | Human | Liver | HCC | 3.53e-61 | 2.92e+00 | 0.2375 |
64849 | SLC13A3 | S016 | Human | Liver | HCC | 7.07e-61 | 2.13e+00 | 0.2243 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:015010411 | Liver | HCC | transport across blood-brain barrier | 50/7958 | 87/18723 | 3.42e-03 | 1.55e-02 | 50 |
GO:001023211 | Liver | HCC | vascular transport | 50/7958 | 88/18723 | 4.69e-03 | 2.02e-02 | 50 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC13A3 | SNV | Missense_Mutation | c.1330N>C | p.Glu444Gln | p.E444Q | Q8WWT9 | protein_coding | deleterious(0.04) | possibly_damaging(0.467) | TCGA-60-2698-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | mithramycin | PD | |
SLC13A3 | SNV | Missense_Mutation | c.212N>G | p.Pro71Arg | p.P71R | Q8WWT9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-NC-A5HO-01 | Lung | lung squamous cell carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | CR | |
SLC13A3 | SNV | Missense_Mutation | novel | c.1126N>T | p.Leu376Phe | p.L376F | Q8WWT9 | protein_coding | deleterious(0) | benign(0.424) | TCGA-O2-A52Q-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
SLC13A3 | SNV | Missense_Mutation | novel | c.1640N>G | p.Thr547Arg | p.T547R | Q8WWT9 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-CN-A63U-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SLC13A3 | SNV | Missense_Mutation | novel | c.397N>A | p.Val133Met | p.V133M | Q8WWT9 | protein_coding | tolerated(0.16) | benign(0.044) | TCGA-CN-A641-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
SLC13A3 | SNV | Missense_Mutation | rs368814380 | c.853N>G | p.Leu285Val | p.L285V | Q8WWT9 | protein_coding | tolerated(0.15) | probably_damaging(0.999) | TCGA-CV-7406-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SLC13A3 | SNV | Missense_Mutation | rs746862161 | c.1478N>T | p.Pro493Leu | p.P493L | Q8WWT9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CV-A45W-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SLC13A3 | SNV | Missense_Mutation | novel | c.1739C>T | p.Ala580Val | p.A580V | Q8WWT9 | protein_coding | deleterious(0.01) | benign(0.181) | TCGA-CV-A463-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC13A3 | SNV | Missense_Mutation | novel | c.704T>A | p.Leu235His | p.L235H | Q8WWT9 | protein_coding | tolerated(0.08) | probably_damaging(1) | TCGA-UF-A71B-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SLC13A3 | SNV | Missense_Mutation | novel | c.686A>T | p.Asn229Ile | p.N229I | Q8WWT9 | protein_coding | tolerated(0.06) | possibly_damaging(0.766) | TCGA-UF-A7J9-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |