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Gene: SIMC1 |
Gene summary for SIMC1 |
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Gene information | Species | Human | Gene symbol | SIMC1 | Gene ID | 375484 |
Gene name | SUMO interacting motifs containing 1 | |
Gene Alias | C5orf25 | |
Cytomap | 5q35.2 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | B4DRM7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
375484 | SIMC1 | CCI_2 | Human | Cervix | CC | 3.87e-12 | 1.01e+00 | 0.5249 |
375484 | SIMC1 | CCI_3 | Human | Cervix | CC | 9.44e-06 | 5.43e-01 | 0.516 |
375484 | SIMC1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.45e-15 | -6.36e-01 | 0.0155 |
375484 | SIMC1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.09e-02 | -5.01e-01 | -0.1808 |
375484 | SIMC1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.32e-05 | -5.86e-01 | -0.1207 |
375484 | SIMC1 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.73e-09 | -5.08e-01 | -0.1464 |
375484 | SIMC1 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.01e-04 | -4.41e-01 | -0.1001 |
375484 | SIMC1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.59e-02 | -6.76e-01 | -0.1462 |
375484 | SIMC1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.23e-02 | -6.34e-01 | -0.0179 |
375484 | SIMC1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.18e-10 | -5.66e-01 | 0.096 |
375484 | SIMC1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 6.31e-07 | -4.88e-01 | 0.0674 |
375484 | SIMC1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.87e-05 | -5.48e-01 | 0.0588 |
375484 | SIMC1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.55e-35 | -7.97e-01 | 0.294 |
375484 | SIMC1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.41e-10 | -5.07e-01 | 0.3859 |
375484 | SIMC1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.33e-05 | -6.61e-01 | 0.2585 |
375484 | SIMC1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.57e-18 | -6.27e-01 | 0.3005 |
375484 | SIMC1 | F007 | Human | Colorectum | FAP | 2.35e-03 | -3.05e-01 | 0.1176 |
375484 | SIMC1 | A001-C-207 | Human | Colorectum | FAP | 3.07e-03 | -3.11e-01 | 0.1278 |
375484 | SIMC1 | A015-C-203 | Human | Colorectum | FAP | 8.11e-34 | -4.91e-01 | -0.1294 |
375484 | SIMC1 | A015-C-204 | Human | Colorectum | FAP | 2.06e-08 | -2.78e-01 | -0.0228 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005254710 | Cervix | CC | regulation of peptidase activity | 112/2311 | 461/18723 | 6.70e-13 | 3.08e-10 | 112 |
GO:004586110 | Cervix | CC | negative regulation of proteolysis | 80/2311 | 351/18723 | 2.88e-08 | 1.98e-06 | 80 |
GO:00513469 | Cervix | CC | negative regulation of hydrolase activity | 81/2311 | 379/18723 | 4.27e-07 | 1.67e-05 | 81 |
GO:00104669 | Cervix | CC | negative regulation of peptidase activity | 60/2311 | 262/18723 | 1.27e-06 | 4.34e-05 | 60 |
GO:0052547 | Colorectum | AD | regulation of peptidase activity | 137/3918 | 461/18723 | 4.12e-06 | 1.12e-04 | 137 |
GO:0045861 | Colorectum | AD | negative regulation of proteolysis | 106/3918 | 351/18723 | 2.33e-05 | 4.57e-04 | 106 |
GO:00525471 | Colorectum | SER | regulation of peptidase activity | 114/2897 | 461/18723 | 1.18e-07 | 7.17e-06 | 114 |
GO:00458611 | Colorectum | SER | negative regulation of proteolysis | 88/2897 | 351/18723 | 1.74e-06 | 7.50e-05 | 88 |
GO:0051346 | Colorectum | SER | negative regulation of hydrolase activity | 82/2897 | 379/18723 | 8.19e-04 | 1.01e-02 | 82 |
GO:0010466 | Colorectum | SER | negative regulation of peptidase activity | 57/2897 | 262/18723 | 4.15e-03 | 3.38e-02 | 57 |
GO:00525472 | Colorectum | MSS | regulation of peptidase activity | 130/3467 | 461/18723 | 1.81e-07 | 8.13e-06 | 130 |
GO:00458612 | Colorectum | MSS | negative regulation of proteolysis | 97/3467 | 351/18723 | 1.57e-05 | 3.54e-04 | 97 |
GO:00513461 | Colorectum | MSS | negative regulation of hydrolase activity | 92/3467 | 379/18723 | 2.85e-03 | 2.22e-02 | 92 |
GO:00525474 | Colorectum | FAP | regulation of peptidase activity | 86/2622 | 461/18723 | 2.98e-03 | 2.27e-02 | 86 |
GO:00458614 | Colorectum | FAP | negative regulation of proteolysis | 68/2622 | 351/18723 | 3.07e-03 | 2.31e-02 | 68 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SIMC1 | SNV | Missense_Mutation | novel | c.1957C>A | p.Gln653Lys | p.Q653K | protein_coding | deleterious(0.03) | benign(0.152) | TCGA-34-5231-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SIMC1 | SNV | Missense_Mutation | novel | c.1448T>C | p.Leu483Ser | p.L483S | protein_coding | tolerated(0.1) | benign(0.088) | TCGA-58-8391-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD | |
SIMC1 | SNV | Missense_Mutation | novel | c.997N>T | p.Gly333Trp | p.G333W | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.713) | TCGA-66-2795-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
SIMC1 | SNV | Missense_Mutation | c.2624C>T | p.Ala875Val | p.A875V | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.79) | TCGA-P3-A5Q5-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
SIMC1 | SNV | Missense_Mutation | novel | c.2326N>G | p.Gln776Glu | p.Q776E | protein_coding | tolerated(0.09) | probably_damaging(0.969) | TCGA-UF-A7JO-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SIMC1 | SNV | Missense_Mutation | novel | c.347N>A | p.Ser116Asn | p.S116N | protein_coding | tolerated_low_confidence(0.13) | benign(0.003) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD | |
SIMC1 | SNV | Missense_Mutation | rs770658102 | c.2309N>T | p.Thr770Met | p.T770M | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD | |
SIMC1 | SNV | Missense_Mutation | rs564067290 | c.2209N>T | p.Arg737Cys | p.R737C | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-B7-A5TI-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | eloxatin | CR | |
SIMC1 | SNV | Missense_Mutation | c.2533N>T | p.Arg845Cys | p.R845C | protein_coding | tolerated(0.15) | possibly_damaging(0.742) | TCGA-BR-8361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
SIMC1 | SNV | Missense_Mutation | c.1537N>G | p.Phe513Val | p.F513V | protein_coding | deleterious(0) | probably_damaging(0.909) | TCGA-BR-8589-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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