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Gene: RUSC1 |
Gene summary for RUSC1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | RUSC1 | Gene ID | 23623 |
Gene name | RUN and SH3 domain containing 1 | |
Gene Alias | NESCA | |
Cytomap | 1q22 | |
Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | Q9BVN2 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23623 | RUSC1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.55e-07 | 4.59e-01 | -0.1808 |
23623 | RUSC1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.82e-04 | 2.76e-01 | -0.0811 |
23623 | RUSC1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.14e-02 | 2.97e-01 | -0.1088 |
23623 | RUSC1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.16e-09 | 3.33e-01 | -0.1954 |
23623 | RUSC1 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.14e-04 | 5.86e-01 | -0.2602 |
23623 | RUSC1 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.50e-04 | 3.44e-01 | -0.1526 |
23623 | RUSC1 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.63e-05 | 3.10e-01 | -0.1464 |
23623 | RUSC1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.28e-10 | 4.44e-01 | -0.059 |
23623 | RUSC1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 4.78e-06 | 4.91e-01 | -0.1706 |
23623 | RUSC1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.52e-04 | 5.10e-01 | -0.2061 |
23623 | RUSC1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.53e-02 | 2.84e-01 | 0.3859 |
23623 | RUSC1 | LZE2T | Human | Esophagus | ESCC | 3.97e-04 | 6.43e-01 | 0.082 |
23623 | RUSC1 | LZE4T | Human | Esophagus | ESCC | 2.69e-11 | 2.42e-01 | 0.0811 |
23623 | RUSC1 | LZE7T | Human | Esophagus | ESCC | 3.79e-12 | 6.56e-01 | 0.0667 |
23623 | RUSC1 | LZE8T | Human | Esophagus | ESCC | 1.27e-05 | 2.33e-01 | 0.067 |
23623 | RUSC1 | LZE20T | Human | Esophagus | ESCC | 2.07e-05 | 1.57e-01 | 0.0662 |
23623 | RUSC1 | LZE22T | Human | Esophagus | ESCC | 2.02e-06 | 6.63e-01 | 0.068 |
23623 | RUSC1 | LZE24T | Human | Esophagus | ESCC | 1.92e-23 | 6.34e-01 | 0.0596 |
23623 | RUSC1 | LZE21T | Human | Esophagus | ESCC | 1.73e-05 | 2.93e-01 | 0.0655 |
23623 | RUSC1 | LZE6T | Human | Esophagus | ESCC | 3.44e-05 | 4.97e-01 | 0.0845 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0000209 | Colorectum | AD | protein polyubiquitination | 78/3918 | 236/18723 | 8.71e-06 | 2.06e-04 | 78 |
GO:00002091 | Colorectum | SER | protein polyubiquitination | 58/2897 | 236/18723 | 1.69e-04 | 3.18e-03 | 58 |
GO:00002092 | Colorectum | MSS | protein polyubiquitination | 72/3467 | 236/18723 | 5.19e-06 | 1.42e-04 | 72 |
GO:000020917 | Esophagus | ESCC | protein polyubiquitination | 170/8552 | 236/18723 | 1.40e-16 | 1.09e-14 | 170 |
GO:000020921 | Liver | HCC | protein polyubiquitination | 151/7958 | 236/18723 | 1.90e-11 | 7.59e-10 | 151 |
GO:000020910 | Oral cavity | OSCC | protein polyubiquitination | 150/7305 | 236/18723 | 1.59e-14 | 9.27e-13 | 150 |
GO:000020915 | Oral cavity | LP | protein polyubiquitination | 82/4623 | 236/18723 | 3.23e-04 | 3.26e-03 | 82 |
GO:000020914 | Prostate | Tumor | protein polyubiquitination | 64/3246 | 236/18723 | 1.08e-04 | 1.03e-03 | 64 |
GO:000020924 | Skin | cSCC | protein polyubiquitination | 103/4864 | 236/18723 | 2.57e-09 | 9.09e-08 | 103 |
GO:000020920 | Thyroid | PTC | protein polyubiquitination | 128/5968 | 236/18723 | 7.81e-13 | 3.65e-11 | 128 |
GO:0000209110 | Thyroid | ATC | protein polyubiquitination | 134/6293 | 236/18723 | 1.86e-13 | 9.20e-12 | 134 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RUSC1 | SNV | Missense_Mutation | c.2422N>C | p.Ser808Pro | p.S808P | Q9BVN2 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-D7-A4YT-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
RUSC1 | SNV | Missense_Mutation | c.376C>A | p.Leu126Ile | p.L126I | Q9BVN2 | protein_coding | deleterious_low_confidence(0.02) | benign(0.142) | TCGA-D7-A4YV-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RUSC1 | SNV | Missense_Mutation | c.287N>T | p.Ser96Phe | p.S96F | Q9BVN2 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.994) | TCGA-F1-6874-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RUSC1 | SNV | Missense_Mutation | novel | c.239G>A | p.Gly80Asp | p.G80D | Q9BVN2 | protein_coding | deleterious_low_confidence(0.02) | benign(0.081) | TCGA-HU-8604-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | doxifluridine | SD |
RUSC1 | SNV | Missense_Mutation | rs755259566 | c.2615G>A | p.Arg872His | p.R872H | Q9BVN2 | protein_coding | deleterious(0.01) | benign(0.217) | TCGA-HU-A4GT-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | copolang | SD |
RUSC1 | SNV | Missense_Mutation | c.305N>C | p.Cys102Ser | p.C102S | Q9BVN2 | protein_coding | tolerated_low_confidence(0.13) | benign(0.092) | TCGA-HU-A4GX-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | SD | |
RUSC1 | SNV | Missense_Mutation | c.305N>C | p.Cys102Ser | p.C102S | Q9BVN2 | protein_coding | tolerated_low_confidence(0.13) | benign(0.092) | TCGA-MX-A5UJ-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
RUSC1 | deletion | Frame_Shift_Del | c.1056delN | p.Ser355ArgfsTer66 | p.S355Rfs*66 | Q9BVN2 | protein_coding | TCGA-BR-8363-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
RUSC1 | SNV | Missense_Mutation | rs762416605 | c.2548C>T | p.Arg850Trp | p.R850W | Q9BVN2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EL-A3ZT-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RUSC1 | insertion | In_Frame_Ins | novel | c.2702_2703insTGG | p.Val901_Leu902insGly | p.V901_L902insG | Q9BVN2 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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