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Gene: RFX3 |
Gene summary for RFX3 |
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Gene information | Species | Human | Gene symbol | RFX3 | Gene ID | 5991 |
Gene name | regulatory factor X3 | |
Gene Alias | RFX3 | |
Cytomap | 9p24.2 | |
Gene Type | protein-coding | GO ID | GO:0001539 | UniProtAcc | P48380 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5991 | RFX3 | CCI_1 | Human | Cervix | CC | 1.02e-03 | 4.93e-01 | 0.528 |
5991 | RFX3 | CCI_2 | Human | Cervix | CC | 4.39e-14 | 1.18e+00 | 0.5249 |
5991 | RFX3 | CCI_3 | Human | Cervix | CC | 9.58e-28 | 1.13e+00 | 0.516 |
5991 | RFX3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.56e-15 | -5.82e-01 | 0.0155 |
5991 | RFX3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.55e-04 | -5.44e-01 | -0.1808 |
5991 | RFX3 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.07e-02 | -7.52e-01 | 0.0216 |
5991 | RFX3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.22e-02 | -2.92e-01 | -0.0811 |
5991 | RFX3 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.90e-03 | -3.58e-01 | -0.1088 |
5991 | RFX3 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.55e-07 | -6.85e-01 | -0.1207 |
5991 | RFX3 | HTA11_696_2000001011 | Human | Colorectum | AD | 6.32e-07 | -4.27e-01 | -0.1464 |
5991 | RFX3 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.14e-12 | -4.92e-01 | -0.1001 |
5991 | RFX3 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.19e-02 | -4.53e-01 | 0.096 |
5991 | RFX3 | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.83e-03 | -6.57e-01 | 0.0528 |
5991 | RFX3 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.75e-08 | -6.07e-01 | 0.0338 |
5991 | RFX3 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.47e-13 | -4.94e-01 | 0.0674 |
5991 | RFX3 | HTA11_6818_2000001011 | Human | Colorectum | AD | 4.83e-03 | -6.37e-01 | 0.0112 |
5991 | RFX3 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 7.28e-04 | -3.10e-01 | 0.294 |
5991 | RFX3 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.36e-03 | 7.90e-01 | 0.3487 |
5991 | RFX3 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 6.07e-03 | -3.48e-01 | 0.3859 |
5991 | RFX3 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 6.11e-04 | -6.06e-01 | 0.2585 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00107206 | Cervix | CC | positive regulation of cell development | 64/2311 | 298/18723 | 5.69e-06 | 1.41e-04 | 64 |
GO:00308563 | Cervix | CC | regulation of epithelial cell differentiation | 36/2311 | 154/18723 | 1.02e-04 | 1.31e-03 | 36 |
GO:000206410 | Cervix | CC | epithelial cell development | 45/2311 | 220/18723 | 4.14e-04 | 4.21e-03 | 45 |
GO:00158337 | Cervix | CC | peptide transport | 46/2311 | 264/18723 | 9.69e-03 | 4.78e-02 | 46 |
GO:0002064 | Colorectum | AD | epithelial cell development | 89/3918 | 220/18723 | 2.98e-11 | 3.52e-09 | 89 |
GO:0050708 | Colorectum | AD | regulation of protein secretion | 83/3918 | 268/18723 | 6.59e-05 | 1.07e-03 | 83 |
GO:0009306 | Colorectum | AD | protein secretion | 105/3918 | 359/18723 | 1.05e-04 | 1.57e-03 | 105 |
GO:0035592 | Colorectum | AD | establishment of protein localization to extracellular region | 105/3918 | 360/18723 | 1.18e-04 | 1.73e-03 | 105 |
GO:0071692 | Colorectum | AD | protein localization to extracellular region | 106/3918 | 368/18723 | 1.86e-04 | 2.49e-03 | 106 |
GO:0050796 | Colorectum | AD | regulation of insulin secretion | 54/3918 | 165/18723 | 2.60e-04 | 3.25e-03 | 54 |
GO:0010720 | Colorectum | AD | positive regulation of cell development | 87/3918 | 298/18723 | 4.17e-04 | 4.71e-03 | 87 |
GO:0030073 | Colorectum | AD | insulin secretion | 61/3918 | 195/18723 | 4.28e-04 | 4.81e-03 | 61 |
GO:0015833 | Colorectum | AD | peptide transport | 77/3918 | 264/18723 | 8.90e-04 | 8.60e-03 | 77 |
GO:0090087 | Colorectum | AD | regulation of peptide transport | 60/3918 | 202/18723 | 1.94e-03 | 1.58e-02 | 60 |
GO:0030072 | Colorectum | AD | peptide hormone secretion | 68/3918 | 236/18723 | 2.39e-03 | 1.85e-02 | 68 |
GO:0002791 | Colorectum | AD | regulation of peptide secretion | 59/3918 | 200/18723 | 2.50e-03 | 1.92e-02 | 59 |
GO:0090276 | Colorectum | AD | regulation of peptide hormone secretion | 58/3918 | 196/18723 | 2.51e-03 | 1.92e-02 | 58 |
GO:0002790 | Colorectum | AD | peptide secretion | 69/3918 | 242/18723 | 2.97e-03 | 2.22e-02 | 69 |
GO:0042886 | Colorectum | AD | amide transport | 83/3918 | 301/18723 | 3.37e-03 | 2.46e-02 | 83 |
GO:00020641 | Colorectum | SER | epithelial cell development | 64/2897 | 220/18723 | 1.96e-07 | 1.10e-05 | 64 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RFX3 | SNV | Missense_Mutation | novel | c.1847G>A | p.Ser616Asn | p.S616N | P48380 | protein_coding | deleterious(0) | possibly_damaging(0.764) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
RFX3 | SNV | Missense_Mutation | novel | c.1496A>G | p.Tyr499Cys | p.Y499C | P48380 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
RFX3 | SNV | Missense_Mutation | novel | c.1727T>C | p.Val576Ala | p.V576A | P48380 | protein_coding | deleterious(0) | possibly_damaging(0.715) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD |
RFX3 | SNV | Missense_Mutation | c.1583G>A | p.Arg528His | p.R528H | P48380 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
RFX3 | SNV | Missense_Mutation | c.677N>T | p.Gly226Val | p.G226V | P48380 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-HF-7132-01 | Stomach | stomach adenocarcinoma | Male | Unknown | I/II | Chemotherapy | fluorouracil | SD | |
RFX3 | SNV | Missense_Mutation | c.364N>A | p.Val122Ile | p.V122I | P48380 | protein_coding | tolerated(0.19) | benign(0.079) | TCGA-HU-A4H4-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | ts-1 | CR | |
RFX3 | insertion | Frame_Shift_Ins | novel | c.971_972insT | p.Leu324PhefsTer14 | p.L324Ffs*14 | P48380 | protein_coding | TCGA-BR-4363-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
RFX3 | SNV | Missense_Mutation | rs761648659 | c.65N>A | p.Ser22Asn | p.S22N | P48380 | protein_coding | deleterious(0.02) | benign(0.077) | TCGA-EM-A1CT-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
RFX3 | insertion | Frame_Shift_Ins | novel | c.1913_1914insTAAGCACATA | p.Glu639LysfsTer24 | p.E639Kfs*24 | P48380 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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