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Gene: PREPL |
Gene summary for PREPL |
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Gene information | Species | Human | Gene symbol | PREPL | Gene ID | 9581 |
Gene name | prolyl endopeptidase like | |
Gene Alias | CMS22 | |
Cytomap | 2p21 | |
Gene Type | protein-coding | GO ID | GO:0001505 | UniProtAcc | Q4J6C6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9581 | PREPL | LZE2T | Human | Esophagus | ESCC | 3.47e-03 | 4.69e-01 | 0.082 |
9581 | PREPL | LZE4T | Human | Esophagus | ESCC | 1.50e-08 | 2.25e-01 | 0.0811 |
9581 | PREPL | LZE7T | Human | Esophagus | ESCC | 6.37e-07 | 3.21e-01 | 0.0667 |
9581 | PREPL | LZE22T | Human | Esophagus | ESCC | 8.56e-03 | 2.34e-01 | 0.068 |
9581 | PREPL | LZE24T | Human | Esophagus | ESCC | 9.18e-14 | 3.15e-01 | 0.0596 |
9581 | PREPL | LZE6T | Human | Esophagus | ESCC | 5.76e-05 | 1.58e-01 | 0.0845 |
9581 | PREPL | P2T-E | Human | Esophagus | ESCC | 8.69e-32 | 5.06e-01 | 0.1177 |
9581 | PREPL | P4T-E | Human | Esophagus | ESCC | 1.64e-17 | 2.94e-01 | 0.1323 |
9581 | PREPL | P5T-E | Human | Esophagus | ESCC | 3.35e-10 | 1.17e-01 | 0.1327 |
9581 | PREPL | P8T-E | Human | Esophagus | ESCC | 1.43e-08 | 2.19e-01 | 0.0889 |
9581 | PREPL | P9T-E | Human | Esophagus | ESCC | 1.72e-14 | 1.50e-01 | 0.1131 |
9581 | PREPL | P10T-E | Human | Esophagus | ESCC | 2.65e-26 | 4.48e-01 | 0.116 |
9581 | PREPL | P11T-E | Human | Esophagus | ESCC | 3.75e-11 | 3.69e-01 | 0.1426 |
9581 | PREPL | P12T-E | Human | Esophagus | ESCC | 3.00e-13 | 2.59e-01 | 0.1122 |
9581 | PREPL | P15T-E | Human | Esophagus | ESCC | 1.19e-11 | 2.80e-01 | 0.1149 |
9581 | PREPL | P16T-E | Human | Esophagus | ESCC | 2.69e-34 | 4.89e-01 | 0.1153 |
9581 | PREPL | P17T-E | Human | Esophagus | ESCC | 7.03e-08 | 2.39e-01 | 0.1278 |
9581 | PREPL | P19T-E | Human | Esophagus | ESCC | 4.60e-11 | 5.00e-01 | 0.1662 |
9581 | PREPL | P20T-E | Human | Esophagus | ESCC | 1.10e-13 | 3.23e-01 | 0.1124 |
9581 | PREPL | P21T-E | Human | Esophagus | ESCC | 7.07e-11 | 1.96e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004819318 | Esophagus | ESCC | Golgi vesicle transport | 231/8552 | 296/18723 | 1.82e-30 | 9.63e-28 | 231 |
GO:001619715 | Esophagus | ESCC | endosomal transport | 168/8552 | 230/18723 | 2.28e-17 | 1.93e-15 | 168 |
GO:0090150110 | Esophagus | ESCC | establishment of protein localization to membrane | 182/8552 | 260/18723 | 1.27e-15 | 8.19e-14 | 182 |
GO:0072659110 | Esophagus | ESCC | protein localization to plasma membrane | 193/8552 | 284/18723 | 1.95e-14 | 1.03e-12 | 193 |
GO:001648210 | Esophagus | ESCC | cytosolic transport | 124/8552 | 168/18723 | 9.69e-14 | 4.69e-12 | 124 |
GO:199077819 | Esophagus | ESCC | protein localization to cell periphery | 217/8552 | 333/18723 | 4.08e-13 | 1.88e-11 | 217 |
GO:000689215 | Esophagus | ESCC | post-Golgi vesicle-mediated transport | 82/8552 | 104/18723 | 4.00e-12 | 1.55e-10 | 82 |
GO:009887615 | Esophagus | ESCC | vesicle-mediated transport to the plasma membrane | 99/8552 | 136/18723 | 1.13e-10 | 3.39e-09 | 99 |
GO:000689315 | Esophagus | ESCC | Golgi to plasma membrane transport | 48/8552 | 60/18723 | 5.11e-08 | 9.16e-07 | 48 |
GO:004300114 | Esophagus | ESCC | Golgi to plasma membrane protein transport | 34/8552 | 40/18723 | 3.00e-07 | 4.27e-06 | 34 |
GO:00421477 | Esophagus | ESCC | retrograde transport, endosome to Golgi | 63/8552 | 91/18723 | 4.58e-06 | 4.87e-05 | 63 |
GO:006195114 | Esophagus | ESCC | establishment of protein localization to plasma membrane | 44/8552 | 60/18723 | 1.25e-05 | 1.15e-04 | 44 |
GO:004819311 | Liver | Cirrhotic | Golgi vesicle transport | 153/4634 | 296/18723 | 1.02e-23 | 6.43e-21 | 153 |
GO:00901507 | Liver | Cirrhotic | establishment of protein localization to membrane | 123/4634 | 260/18723 | 1.85e-15 | 2.15e-13 | 123 |
GO:199077811 | Liver | Cirrhotic | protein localization to cell periphery | 135/4634 | 333/18723 | 1.18e-10 | 6.21e-09 | 135 |
GO:007265911 | Liver | Cirrhotic | protein localization to plasma membrane | 119/4634 | 284/18723 | 1.30e-10 | 6.80e-09 | 119 |
GO:004300111 | Liver | Cirrhotic | Golgi to plasma membrane protein transport | 27/4634 | 40/18723 | 1.43e-08 | 5.36e-07 | 27 |
GO:001648211 | Liver | Cirrhotic | cytosolic transport | 74/4634 | 168/18723 | 3.34e-08 | 1.12e-06 | 74 |
GO:000689211 | Liver | Cirrhotic | post-Golgi vesicle-mediated transport | 51/4634 | 104/18723 | 7.12e-08 | 2.15e-06 | 51 |
GO:001619711 | Liver | Cirrhotic | endosomal transport | 93/4634 | 230/18723 | 1.01e-07 | 2.93e-06 | 93 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PREPL | SNV | Missense_Mutation | c.868G>A | p.Val290Ile | p.V290I | Q4J6C6 | protein_coding | tolerated(0.33) | benign(0.033) | TCGA-BR-6705-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
PREPL | SNV | Missense_Mutation | c.452N>G | p.Leu151Arg | p.L151R | Q4J6C6 | protein_coding | deleterious(0.02) | probably_damaging(0.963) | TCGA-BR-8589-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
PREPL | SNV | Missense_Mutation | rs778873576 | c.1570N>T | p.Arg524Cys | p.R524C | Q4J6C6 | protein_coding | tolerated(0.09) | benign(0.006) | TCGA-D7-A4YU-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | SD |
PREPL | SNV | Missense_Mutation | c.1492G>T | p.Val498Leu | p.V498L | Q4J6C6 | protein_coding | tolerated(0.88) | benign(0.041) | TCGA-HU-A4GU-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PREPL | SNV | Missense_Mutation | c.710N>G | p.Asp237Gly | p.D237G | Q4J6C6 | protein_coding | tolerated(0.18) | benign(0.012) | TCGA-HU-A4H8-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | didox | PD | |
PREPL | SNV | Missense_Mutation | c.719N>A | p.Arg240His | p.R240H | Q4J6C6 | protein_coding | tolerated(0.78) | benign(0.054) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | ||
PREPL | SNV | Missense_Mutation | novel | c.745N>C | p.Asp249His | p.D249H | Q4J6C6 | protein_coding | deleterious(0.03) | probably_damaging(0.969) | TCGA-VQ-A8PH-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
PREPL | SNV | Missense_Mutation | novel | c.2030N>T | p.Thr677Ile | p.T677I | Q4J6C6 | protein_coding | tolerated(0.58) | benign(0.001) | TCGA-VQ-A94U-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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