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Gene: PLCH2 |
Gene summary for PLCH2 |
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Gene information | Species | Human | Gene symbol | PLCH2 | Gene ID | 9651 |
Gene name | phospholipase C eta 2 | |
Gene Alias | PLC-L4 | |
Cytomap | 1p36.32 | |
Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | O75038 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9651 | PLCH2 | C04 | Human | Oral cavity | OSCC | 1.67e-07 | 3.36e-01 | 0.2633 |
9651 | PLCH2 | C21 | Human | Oral cavity | OSCC | 4.86e-12 | 3.46e-01 | 0.2678 |
9651 | PLCH2 | C30 | Human | Oral cavity | OSCC | 1.12e-28 | 1.04e+00 | 0.3055 |
9651 | PLCH2 | C38 | Human | Oral cavity | OSCC | 8.63e-05 | 4.45e-01 | 0.172 |
9651 | PLCH2 | C43 | Human | Oral cavity | OSCC | 7.46e-20 | 4.21e-01 | 0.1704 |
9651 | PLCH2 | C46 | Human | Oral cavity | OSCC | 1.48e-09 | 2.37e-01 | 0.1673 |
9651 | PLCH2 | C51 | Human | Oral cavity | OSCC | 1.61e-03 | 2.71e-01 | 0.2674 |
9651 | PLCH2 | C09 | Human | Oral cavity | OSCC | 2.91e-12 | 3.40e-01 | 0.1431 |
9651 | PLCH2 | LN22 | Human | Oral cavity | OSCC | 3.01e-02 | 3.03e-01 | 0.1733 |
9651 | PLCH2 | LN46 | Human | Oral cavity | OSCC | 2.64e-05 | 2.57e-01 | 0.1666 |
9651 | PLCH2 | LP15 | Human | Oral cavity | LP | 1.44e-03 | 6.76e-01 | 0.2174 |
9651 | PLCH2 | SYSMH2 | Human | Oral cavity | OSCC | 7.25e-05 | 1.53e-01 | 0.2326 |
9651 | PLCH2 | SYSMH3 | Human | Oral cavity | OSCC | 2.19e-27 | 5.45e-01 | 0.2442 |
9651 | PLCH2 | SYSMH4 | Human | Oral cavity | OSCC | 3.27e-02 | 1.32e-01 | 0.1226 |
9651 | PLCH2 | SYSMH5 | Human | Oral cavity | OSCC | 1.56e-05 | 1.81e-01 | 0.0647 |
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Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00066445 | Oral cavity | OSCC | phospholipid metabolic process | 175/7305 | 383/18723 | 4.21e-03 | 1.71e-02 | 175 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLCH2 | SNV | Missense_Mutation | rs754189300 | c.2356N>T | p.Asp786Tyr | p.D786Y | O75038 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-55-8506-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PLCH2 | SNV | Missense_Mutation | rs369208976 | c.452N>A | p.Arg151His | p.R151H | O75038 | protein_coding | deleterious(0.02) | probably_damaging(0.932) | TCGA-55-8507-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PLCH2 | SNV | Missense_Mutation | c.58N>T | p.Ala20Ser | p.A20S | O75038 | protein_coding | deleterious_low_confidence(0.01) | benign(0.411) | TCGA-55-8514-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PLCH2 | SNV | Missense_Mutation | c.3803N>T | p.Ser1268Ile | p.S1268I | O75038 | protein_coding | deleterious_low_confidence(0.01) | benign(0.052) | TCGA-69-7979-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PLCH2 | SNV | Missense_Mutation | c.725N>T | p.Arg242Leu | p.R242L | O75038 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-78-7160-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Unspecific | SD | ||
PLCH2 | SNV | Missense_Mutation | c.1034T>A | p.Leu345His | p.L345H | O75038 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-L9-A443-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PLCH2 | SNV | Missense_Mutation | novel | c.545N>T | p.Asp182Val | p.D182V | O75038 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-58-A46M-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PLCH2 | SNV | Missense_Mutation | rs369356142 | c.2533N>T | p.Arg845Cys | p.R845C | O75038 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-63-A5MM-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
PLCH2 | SNV | Missense_Mutation | c.2509G>T | p.Val837Phe | p.V837F | O75038 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-77-8143-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
PLCH2 | SNV | Missense_Mutation | rs756323592 | c.1402N>T | p.Val468Leu | p.V468L | O75038 | protein_coding | tolerated(0.13) | possibly_damaging(0.458) | TCGA-85-6798-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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