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Gene: PLCH1 |
Gene summary for PLCH1 |
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Gene information | Species | Human | Gene symbol | PLCH1 | Gene ID | 23007 |
Gene name | phospholipase C eta 1 | |
Gene Alias | PLC eta 1 | |
Cytomap | 3q25.31 | |
Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | Q4KWH8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23007 | PLCH1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.32e-12 | -5.10e-01 | 0.0155 |
23007 | PLCH1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.86e-08 | -6.23e-01 | -0.1207 |
23007 | PLCH1 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.15e-04 | -4.02e-01 | 0.096 |
23007 | PLCH1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.97e-03 | -3.73e-01 | 0.0674 |
23007 | PLCH1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 5.31e-05 | -5.90e-01 | 0.2585 |
23007 | PLCH1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.09e-17 | -6.29e-01 | 0.3005 |
23007 | PLCH1 | A015-C-203 | Human | Colorectum | FAP | 2.02e-21 | -4.45e-01 | -0.1294 |
23007 | PLCH1 | A015-C-204 | Human | Colorectum | FAP | 2.43e-05 | -2.17e-01 | -0.0228 |
23007 | PLCH1 | A014-C-040 | Human | Colorectum | FAP | 2.92e-04 | -3.67e-01 | -0.1184 |
23007 | PLCH1 | A002-C-201 | Human | Colorectum | FAP | 2.70e-14 | -3.24e-01 | 0.0324 |
23007 | PLCH1 | A002-C-203 | Human | Colorectum | FAP | 1.61e-02 | 1.42e-01 | 0.2786 |
23007 | PLCH1 | A001-C-119 | Human | Colorectum | FAP | 7.53e-07 | -3.34e-01 | -0.1557 |
23007 | PLCH1 | A001-C-108 | Human | Colorectum | FAP | 1.94e-12 | -2.54e-01 | -0.0272 |
23007 | PLCH1 | A002-C-205 | Human | Colorectum | FAP | 6.46e-21 | -3.16e-01 | -0.1236 |
23007 | PLCH1 | A015-C-005 | Human | Colorectum | FAP | 3.13e-03 | -1.84e-01 | -0.0336 |
23007 | PLCH1 | A015-C-006 | Human | Colorectum | FAP | 1.89e-15 | -3.73e-01 | -0.0994 |
23007 | PLCH1 | A015-C-106 | Human | Colorectum | FAP | 4.02e-09 | -3.24e-01 | -0.0511 |
23007 | PLCH1 | A002-C-114 | Human | Colorectum | FAP | 4.22e-20 | -4.52e-01 | -0.1561 |
23007 | PLCH1 | A015-C-104 | Human | Colorectum | FAP | 1.32e-23 | -3.79e-01 | -0.1899 |
23007 | PLCH1 | A001-C-014 | Human | Colorectum | FAP | 4.21e-08 | -2.87e-01 | 0.0135 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016042 | Colorectum | AD | lipid catabolic process | 97/3918 | 320/18723 | 4.31e-05 | 7.56e-04 | 97 |
GO:0048017 | Colorectum | AD | inositol lipid-mediated signaling | 53/3918 | 182/18723 | 5.35e-03 | 3.52e-02 | 53 |
GO:0048015 | Colorectum | AD | phosphatidylinositol-mediated signaling | 52/3918 | 178/18723 | 5.37e-03 | 3.54e-02 | 52 |
GO:00160422 | Colorectum | MSS | lipid catabolic process | 77/3467 | 320/18723 | 7.43e-03 | 4.71e-02 | 77 |
GO:00160423 | Colorectum | FAP | lipid catabolic process | 65/2622 | 320/18723 | 1.13e-03 | 1.08e-02 | 65 |
GO:00160424 | Colorectum | CRC | lipid catabolic process | 53/2078 | 320/18723 | 1.89e-03 | 1.93e-02 | 53 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00562 | Colorectum | CRC | Inositol phosphate metabolism | 18/1091 | 73/8465 | 4.38e-03 | 2.52e-02 | 1.71e-02 | 18 |
hsa005621 | Colorectum | CRC | Inositol phosphate metabolism | 18/1091 | 73/8465 | 4.38e-03 | 2.52e-02 | 1.71e-02 | 18 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLCH1 | SNV | Missense_Mutation | novel | c.735N>T | p.Lys245Asn | p.K245N | Q4KWH8 | protein_coding | deleterious(0.02) | probably_damaging(0.995) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
PLCH1 | SNV | Missense_Mutation | novel | c.399N>C | p.Glu133Asp | p.E133D | Q4KWH8 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
PLCH1 | SNV | Missense_Mutation | novel | c.1054N>A | p.Asp352Asn | p.D352N | Q4KWH8 | protein_coding | deleterious(0.04) | probably_damaging(0.998) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PLCH1 | SNV | Missense_Mutation | novel | c.889N>T | p.Val297Leu | p.V297L | Q4KWH8 | protein_coding | deleterious(0.02) | probably_damaging(0.934) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PLCH1 | SNV | Missense_Mutation | rs368685875 | c.4582N>A | p.Gly1528Ser | p.G1528S | Q4KWH8 | protein_coding | tolerated(0.77) | benign(0.001) | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PLCH1 | SNV | Missense_Mutation | c.3523N>T | p.Ser1175Cys | p.S1175C | Q4KWH8 | protein_coding | deleterious_low_confidence(0.03) | possibly_damaging(0.579) | TCGA-AG-A01W-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
PLCH1 | SNV | Missense_Mutation | rs745842023 | c.1301N>A | p.Ser434Asn | p.S434N | Q4KWH8 | protein_coding | tolerated(0.28) | benign(0.02) | TCGA-AH-6643-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | PD |
PLCH1 | SNV | Missense_Mutation | novel | c.1897N>A | p.Ala633Thr | p.A633T | Q4KWH8 | protein_coding | deleterious(0.01) | probably_damaging(0.934) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
PLCH1 | SNV | Missense_Mutation | novel | c.4639N>T | p.Arg1547Trp | p.R1547W | Q4KWH8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PLCH1 | SNV | Missense_Mutation | novel | c.23N>C | p.Lys8Thr | p.K8T | Q4KWH8 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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