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Gene: PHRF1 |
Gene summary for PHRF1 |
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Gene information | Species | Human | Gene symbol | PHRF1 | Gene ID | 57661 |
Gene name | PHD and ring finger domains 1 | |
Gene Alias | PPP1R125 | |
Cytomap | 11p15.5 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A024RCA1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57661 | PHRF1 | LZE7T | Human | Esophagus | ESCC | 1.36e-02 | 1.72e-01 | 0.0667 |
57661 | PHRF1 | LZE24T | Human | Esophagus | ESCC | 5.48e-06 | 1.80e-01 | 0.0596 |
57661 | PHRF1 | P1T-E | Human | Esophagus | ESCC | 1.95e-09 | 3.06e-01 | 0.0875 |
57661 | PHRF1 | P2T-E | Human | Esophagus | ESCC | 1.19e-15 | 2.03e-01 | 0.1177 |
57661 | PHRF1 | P4T-E | Human | Esophagus | ESCC | 8.81e-07 | 8.40e-02 | 0.1323 |
57661 | PHRF1 | P5T-E | Human | Esophagus | ESCC | 7.93e-05 | 8.74e-02 | 0.1327 |
57661 | PHRF1 | P8T-E | Human | Esophagus | ESCC | 3.86e-05 | 9.63e-02 | 0.0889 |
57661 | PHRF1 | P9T-E | Human | Esophagus | ESCC | 6.30e-16 | 2.85e-01 | 0.1131 |
57661 | PHRF1 | P10T-E | Human | Esophagus | ESCC | 1.71e-11 | 1.97e-01 | 0.116 |
57661 | PHRF1 | P11T-E | Human | Esophagus | ESCC | 9.96e-12 | 3.17e-01 | 0.1426 |
57661 | PHRF1 | P12T-E | Human | Esophagus | ESCC | 1.53e-07 | 1.50e-01 | 0.1122 |
57661 | PHRF1 | P15T-E | Human | Esophagus | ESCC | 1.83e-06 | 1.16e-01 | 0.1149 |
57661 | PHRF1 | P16T-E | Human | Esophagus | ESCC | 4.98e-07 | 8.32e-02 | 0.1153 |
57661 | PHRF1 | P17T-E | Human | Esophagus | ESCC | 2.57e-04 | 2.70e-01 | 0.1278 |
57661 | PHRF1 | P20T-E | Human | Esophagus | ESCC | 7.24e-12 | 2.32e-01 | 0.1124 |
57661 | PHRF1 | P21T-E | Human | Esophagus | ESCC | 3.52e-08 | 1.60e-01 | 0.1617 |
57661 | PHRF1 | P22T-E | Human | Esophagus | ESCC | 9.37e-09 | 1.15e-01 | 0.1236 |
57661 | PHRF1 | P23T-E | Human | Esophagus | ESCC | 4.67e-07 | 1.76e-01 | 0.108 |
57661 | PHRF1 | P24T-E | Human | Esophagus | ESCC | 5.30e-05 | 5.37e-02 | 0.1287 |
57661 | PHRF1 | P26T-E | Human | Esophagus | ESCC | 3.42e-09 | 1.73e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PHRF1 | SNV | Missense_Mutation | c.2018N>T | p.Arg673Ile | p.R673I | Q9P1Y6 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PHRF1 | SNV | Missense_Mutation | novel | c.3259N>G | p.Arg1087Gly | p.R1087G | Q9P1Y6 | protein_coding | deleterious(0.02) | benign(0.261) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PHRF1 | SNV | Missense_Mutation | c.3014C>T | p.Ala1005Val | p.A1005V | Q9P1Y6 | protein_coding | tolerated(0.29) | benign(0.007) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PHRF1 | SNV | Missense_Mutation | c.4354N>A | p.Glu1452Lys | p.E1452K | Q9P1Y6 | protein_coding | deleterious(0.01) | benign(0.148) | TCGA-D1-A15X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PHRF1 | SNV | Missense_Mutation | c.2042N>T | p.Arg681Met | p.R681M | Q9P1Y6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-D1-A167-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PHRF1 | SNV | Missense_Mutation | c.3829G>A | p.Asp1277Asn | p.D1277N | Q9P1Y6 | protein_coding | deleterious(0) | benign(0.045) | TCGA-D1-A16J-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
PHRF1 | SNV | Missense_Mutation | rs771102528 | c.409N>A | p.Glu137Lys | p.E137K | Q9P1Y6 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PHRF1 | SNV | Missense_Mutation | novel | c.123C>G | p.Asp41Glu | p.D41E | Q9P1Y6 | protein_coding | tolerated(0.19) | benign(0.156) | TCGA-D1-A1NZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PHRF1 | SNV | Missense_Mutation | novel | c.1966N>T | p.Pro656Ser | p.P656S | Q9P1Y6 | protein_coding | tolerated(0.72) | benign(0) | TCGA-D1-A2G0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PHRF1 | SNV | Missense_Mutation | rs756040853 | c.1094N>T | p.Ala365Val | p.A365V | Q9P1Y6 | protein_coding | deleterious(0.01) | benign(0.113) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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