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Gene: PEG3 |
Gene summary for PEG3 |
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Gene information | Species | Human | Gene symbol | PEG3 | Gene ID | 5178 |
Gene name | paternally expressed 3 | |
Gene Alias | PW1 | |
Cytomap | 19q13.43 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9GZU2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5178 | PEG3 | GSM4909281 | Human | Breast | IDC | 1.58e-28 | 5.45e-01 | 0.21 |
5178 | PEG3 | GSM4909298 | Human | Breast | IDC | 4.14e-61 | 8.98e-01 | 0.1551 |
5178 | PEG3 | GSM4909304 | Human | Breast | IDC | 5.34e-07 | 2.18e-01 | 0.1636 |
5178 | PEG3 | HCC1_Meng | Human | Liver | HCC | 8.95e-10 | 4.36e-02 | 0.0246 |
5178 | PEG3 | HCC2 | Human | Liver | HCC | 1.25e-22 | 3.74e+00 | 0.5341 |
5178 | PEG3 | S014 | Human | Liver | HCC | 2.68e-34 | 1.10e+00 | 0.2254 |
5178 | PEG3 | S015 | Human | Liver | HCC | 3.41e-32 | 1.14e+00 | 0.2375 |
5178 | PEG3 | S016 | Human | Liver | HCC | 4.77e-32 | 1.21e+00 | 0.2243 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
PEG3 | PERI | Cervix | HSIL_HPV | AC006115.2,HES6,SERTM1, etc. | 3.67e-02 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PEG3 | SNV | Missense_Mutation | c.142A>G | p.Arg48Gly | p.R48G | Q9GZU2 | protein_coding | deleterious(0) | benign(0.028) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PEG3 | SNV | Missense_Mutation | rs763208406 | c.332N>T | p.Pro111Leu | p.P111L | Q9GZU2 | protein_coding | deleterious(0) | possibly_damaging(0.793) | TCGA-DM-A280-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PEG3 | SNV | Missense_Mutation | rs766536993 | c.230N>T | p.Pro77Leu | p.P77L | Q9GZU2 | protein_coding | deleterious(0) | possibly_damaging(0.887) | TCGA-G4-6321-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | fluorouracil | SD |
PEG3 | SNV | Missense_Mutation | c.920A>C | p.Asp307Ala | p.D307A | Q9GZU2 | protein_coding | tolerated(0.1) | benign(0.052) | TCGA-NH-A50U-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | PD | |
PEG3 | SNV | Missense_Mutation | rs370009140 | c.3985N>C | p.Ile1329Leu | p.I1329L | Q9GZU2 | protein_coding | tolerated(0.41) | benign(0) | TCGA-AF-A56L-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
PEG3 | SNV | Missense_Mutation | rs750731373 | c.2543N>G | p.Asn848Ser | p.N848S | Q9GZU2 | protein_coding | tolerated(0.94) | benign(0) | TCGA-AG-3725-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PEG3 | SNV | Missense_Mutation | novel | c.1548N>T | p.Lys516Asn | p.K516N | Q9GZU2 | protein_coding | tolerated(0.15) | benign(0.134) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PEG3 | SNV | Missense_Mutation | novel | c.4370N>A | p.Gly1457Asp | p.G1457D | Q9GZU2 | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PEG3 | SNV | Missense_Mutation | rs752710501 | c.3677N>A | p.Arg1226Gln | p.R1226Q | Q9GZU2 | protein_coding | tolerated(0.87) | benign(0.027) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PEG3 | SNV | Missense_Mutation | novel | c.3168N>T | p.Glu1056Asp | p.E1056D | Q9GZU2 | protein_coding | deleterious(0.01) | probably_damaging(0.978) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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