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Gene: PDE5A |
Gene summary for PDE5A |
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Gene information | Species | Human | Gene symbol | PDE5A | Gene ID | 8654 |
Gene name | phosphodiesterase 5A | |
Gene Alias | CGB-PDE | |
Cytomap | 4q26 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | O76074 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8654 | PDE5A | HTA12-15-2 | Human | Pancreas | PDAC | 1.52e-02 | 3.53e-01 | 0.2315 |
8654 | PDE5A | HTA12-26-1 | Human | Pancreas | PDAC | 2.29e-06 | 5.26e-01 | 0.3728 |
8654 | PDE5A | HTA12-29-1 | Human | Pancreas | PDAC | 3.37e-25 | 7.06e-01 | 0.3722 |
8654 | PDE5A | male-WTA | Human | Thyroid | PTC | 1.89e-51 | 6.76e-01 | 0.1037 |
8654 | PDE5A | PTC01 | Human | Thyroid | PTC | 2.98e-48 | 1.02e+00 | 0.1899 |
8654 | PDE5A | PTC03 | Human | Thyroid | PTC | 7.43e-17 | 9.76e-01 | 0.1784 |
8654 | PDE5A | PTC04 | Human | Thyroid | PTC | 2.02e-52 | 1.00e+00 | 0.1927 |
8654 | PDE5A | PTC05 | Human | Thyroid | PTC | 3.76e-62 | 2.54e+00 | 0.2065 |
8654 | PDE5A | PTC06 | Human | Thyroid | PTC | 2.80e-93 | 2.40e+00 | 0.2057 |
8654 | PDE5A | PTC07 | Human | Thyroid | PTC | 2.54e-102 | 1.79e+00 | 0.2044 |
8654 | PDE5A | ATC13 | Human | Thyroid | ATC | 7.30e-10 | 1.85e-01 | 0.34 |
8654 | PDE5A | ATC5 | Human | Thyroid | ATC | 6.33e-12 | 2.04e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0034655112 | Thyroid | PTC | nucleobase-containing compound catabolic process | 211/5968 | 407/18723 | 2.72e-17 | 2.52e-15 | 211 |
GO:0046700111 | Thyroid | PTC | heterocycle catabolic process | 221/5968 | 445/18723 | 2.43e-15 | 1.72e-13 | 221 |
GO:0044270111 | Thyroid | PTC | cellular nitrogen compound catabolic process | 223/5968 | 451/18723 | 3.34e-15 | 2.31e-13 | 223 |
GO:0019439111 | Thyroid | PTC | aromatic compound catabolic process | 225/5968 | 467/18723 | 8.51e-14 | 4.71e-12 | 225 |
GO:1901361111 | Thyroid | PTC | organic cyclic compound catabolic process | 231/5968 | 495/18723 | 2.55e-12 | 1.12e-10 | 231 |
GO:001969327 | Thyroid | PTC | ribose phosphate metabolic process | 176/5968 | 396/18723 | 8.28e-08 | 1.70e-06 | 176 |
GO:000915028 | Thyroid | PTC | purine ribonucleotide metabolic process | 165/5968 | 368/18723 | 1.03e-07 | 2.05e-06 | 165 |
GO:007252127 | Thyroid | PTC | purine-containing compound metabolic process | 182/5968 | 416/18723 | 1.92e-07 | 3.51e-06 | 182 |
GO:000925927 | Thyroid | PTC | ribonucleotide metabolic process | 170/5968 | 385/18723 | 2.32e-07 | 4.08e-06 | 170 |
GO:000616327 | Thyroid | PTC | purine nucleotide metabolic process | 170/5968 | 396/18723 | 2.02e-06 | 2.75e-05 | 170 |
GO:000675325 | Thyroid | PTC | nucleoside phosphate metabolic process | 205/5968 | 497/18723 | 5.24e-06 | 6.35e-05 | 205 |
GO:000911725 | Thyroid | PTC | nucleotide metabolic process | 202/5968 | 489/18723 | 5.46e-06 | 6.60e-05 | 202 |
GO:003465525 | Thyroid | ATC | nucleobase-containing compound catabolic process | 217/6293 | 407/18723 | 1.20e-16 | 1.04e-14 | 217 |
GO:004670024 | Thyroid | ATC | heterocycle catabolic process | 228/6293 | 445/18723 | 7.26e-15 | 4.50e-13 | 228 |
GO:004427025 | Thyroid | ATC | cellular nitrogen compound catabolic process | 229/6293 | 451/18723 | 2.25e-14 | 1.27e-12 | 229 |
GO:001943924 | Thyroid | ATC | aromatic compound catabolic process | 232/6293 | 467/18723 | 3.05e-13 | 1.44e-11 | 232 |
GO:190136124 | Thyroid | ATC | organic cyclic compound catabolic process | 238/6293 | 495/18723 | 1.12e-11 | 4.12e-10 | 238 |
GO:001969328 | Thyroid | ATC | ribose phosphate metabolic process | 184/6293 | 396/18723 | 5.87e-08 | 1.05e-06 | 184 |
GO:000915029 | Thyroid | ATC | purine ribonucleotide metabolic process | 172/6293 | 368/18723 | 9.58e-08 | 1.64e-06 | 172 |
GO:000925928 | Thyroid | ATC | ribonucleotide metabolic process | 178/6293 | 385/18723 | 1.47e-07 | 2.39e-06 | 178 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDE5A | SNV | Missense_Mutation | novel | c.2200N>A | p.Glu734Lys | p.E734K | O76074 | protein_coding | tolerated(0.34) | benign(0.015) | TCGA-EY-A212-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
PDE5A | SNV | Missense_Mutation | c.433N>A | p.Glu145Lys | p.E145K | O76074 | protein_coding | tolerated(0.44) | benign(0.005) | TCGA-FI-A2D2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatinum | PD | |
PDE5A | SNV | Missense_Mutation | rs200971951 | c.665N>A | p.Arg222His | p.R222H | O76074 | protein_coding | tolerated(0.11) | possibly_damaging(0.581) | TCGA-SJ-A6ZI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PDE5A | SNV | Missense_Mutation | novel | c.1565C>A | p.Thr522Lys | p.T522K | O76074 | protein_coding | deleterious(0) | possibly_damaging(0.852) | TCGA-DD-AAC8-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PDE5A | SNV | Missense_Mutation | c.452N>A | p.Arg151Lys | p.R151K | O76074 | protein_coding | tolerated(0.07) | benign(0.053) | TCGA-55-7994-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR | |
PDE5A | SNV | Missense_Mutation | c.1697N>A | p.Leu566Gln | p.L566Q | O76074 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-55-8507-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PDE5A | SNV | Missense_Mutation | novel | c.4N>C | p.Glu2Gln | p.E2Q | O76074 | protein_coding | deleterious_low_confidence(0) | benign(0.019) | TCGA-55-8614-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PDE5A | SNV | Missense_Mutation | rs569083571 | c.1730G>A | p.Arg577Gln | p.R577Q | O76074 | protein_coding | deleterious(0) | probably_damaging(0.912) | TCGA-78-7162-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PDE5A | SNV | Missense_Mutation | c.2572N>C | p.Glu858Gln | p.E858Q | O76074 | protein_coding | tolerated(0.17) | benign(0.017) | TCGA-86-8075-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | etoposide | CR | |
PDE5A | SNV | Missense_Mutation | novel | c.2117T>C | p.Ile706Thr | p.I706T | O76074 | protein_coding | tolerated(0.57) | benign(0.011) | TCGA-MP-A4T4-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8654 | PDE5A | ENZYME, DRUGGABLE GENOME | inhibitor | 178101953 | ||
8654 | PDE5A | ENZYME, DRUGGABLE GENOME | ICARIIN | ICARIIN | ||
8654 | PDE5A | ENZYME, DRUGGABLE GENOME | PENTOXIFYLLINE | PENTOXIFYLLINE | ||
8654 | PDE5A | ENZYME, DRUGGABLE GENOME | AVANAFIL | AVANAFIL | ||
8654 | PDE5A | ENZYME, DRUGGABLE GENOME | ENALAPRIL | ENALAPRIL | 15452190 | |
8654 | PDE5A | ENZYME, DRUGGABLE GENOME | Udenafil | UDENAFIL | ||
8654 | PDE5A | ENZYME, DRUGGABLE GENOME | inhibitor | CHEMBL628 | PENTOXIFYLLINE | |
8654 | PDE5A | ENZYME, DRUGGABLE GENOME | UK-371800 | CHEMBL460293 | ||
8654 | PDE5A | ENZYME, DRUGGABLE GENOME | inhibitor | CHEMBL1963681 | AVANAFIL | |
8654 | PDE5A | ENZYME, DRUGGABLE GENOME | inhibitor | CHEMBL1339 | VARDENAFIL HYDROCHLORIDE |
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