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Gene: PDE4C |
Gene summary for PDE4C |
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Gene information | Species | Human | Gene symbol | PDE4C | Gene ID | 5143 |
Gene name | phosphodiesterase 4C | |
Gene Alias | DPDE1 | |
Cytomap | 19p13.11 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | O43849 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5143 | PDE4C | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.20e-02 | 9.73e-02 | 0.0155 |
5143 | PDE4C | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.18e-27 | 6.86e-01 | -0.1808 |
5143 | PDE4C | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.41e-16 | 4.80e-01 | -0.0811 |
5143 | PDE4C | HTA11_78_2000001011 | Human | Colorectum | AD | 6.11e-04 | 1.68e-01 | -0.1088 |
5143 | PDE4C | HTA11_347_2000001011 | Human | Colorectum | AD | 2.14e-62 | 1.05e+00 | -0.1954 |
5143 | PDE4C | HTA11_411_2000001011 | Human | Colorectum | SER | 6.42e-18 | 1.29e+00 | -0.2602 |
5143 | PDE4C | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.75e-12 | 6.59e-01 | -0.2196 |
5143 | PDE4C | HTA11_3361_2000001011 | Human | Colorectum | AD | 6.03e-08 | 3.50e-01 | -0.1207 |
5143 | PDE4C | HTA11_83_2000001011 | Human | Colorectum | SER | 2.83e-15 | 5.43e-01 | -0.1526 |
5143 | PDE4C | HTA11_696_2000001011 | Human | Colorectum | AD | 3.28e-34 | 6.47e-01 | -0.1464 |
5143 | PDE4C | HTA11_866_2000001011 | Human | Colorectum | AD | 2.71e-26 | 5.05e-01 | -0.1001 |
5143 | PDE4C | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.56e-17 | 4.36e-01 | -0.059 |
5143 | PDE4C | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.02e-19 | 8.95e-01 | -0.1706 |
5143 | PDE4C | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.67e-10 | 4.78e-01 | -0.2061 |
5143 | PDE4C | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.20e-12 | 6.52e-01 | -0.1462 |
5143 | PDE4C | HTA11_546_2000001011 | Human | Colorectum | AD | 1.19e-22 | 7.58e-01 | -0.0842 |
5143 | PDE4C | HTA11_866_3004761011 | Human | Colorectum | AD | 6.26e-04 | 1.18e-01 | 0.096 |
5143 | PDE4C | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.51e-11 | 5.15e-01 | 0.0446 |
5143 | PDE4C | HTA11_9408_2000001011 | Human | Colorectum | AD | 4.54e-06 | 3.39e-01 | 0.0451 |
5143 | PDE4C | HTA11_8622_2000001021 | Human | Colorectum | SER | 6.58e-13 | 5.44e-01 | 0.0528 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0009150 | Colorectum | AD | purine ribonucleotide metabolic process | 142/3918 | 368/18723 | 4.29e-15 | 1.17e-12 | 142 |
GO:0006163 | Colorectum | AD | purine nucleotide metabolic process | 149/3918 | 396/18723 | 1.08e-14 | 2.80e-12 | 149 |
GO:0072521 | Colorectum | AD | purine-containing compound metabolic process | 153/3918 | 416/18723 | 4.34e-14 | 1.01e-11 | 153 |
GO:0009259 | Colorectum | AD | ribonucleotide metabolic process | 144/3918 | 385/18723 | 5.25e-14 | 1.13e-11 | 144 |
GO:0019693 | Colorectum | AD | ribose phosphate metabolic process | 145/3918 | 396/18723 | 3.01e-13 | 5.71e-11 | 145 |
GO:0009117 | Colorectum | AD | nucleotide metabolic process | 168/3918 | 489/18723 | 2.20e-12 | 3.36e-10 | 168 |
GO:0006753 | Colorectum | AD | nucleoside phosphate metabolic process | 169/3918 | 497/18723 | 4.99e-12 | 6.98e-10 | 169 |
GO:0044270 | Colorectum | AD | cellular nitrogen compound catabolic process | 147/3918 | 451/18723 | 3.35e-09 | 2.23e-07 | 147 |
GO:0046700 | Colorectum | AD | heterocycle catabolic process | 145/3918 | 445/18723 | 4.37e-09 | 2.84e-07 | 145 |
GO:0034655 | Colorectum | AD | nucleobase-containing compound catabolic process | 133/3918 | 407/18723 | 1.56e-08 | 9.12e-07 | 133 |
GO:0019439 | Colorectum | AD | aromatic compound catabolic process | 146/3918 | 467/18723 | 7.48e-08 | 3.84e-06 | 146 |
GO:1901361 | Colorectum | AD | organic cyclic compound catabolic process | 153/3918 | 495/18723 | 8.23e-08 | 4.18e-06 | 153 |
GO:0006195 | Colorectum | AD | purine nucleotide catabolic process | 18/3918 | 46/18723 | 3.67e-03 | 2.60e-02 | 18 |
GO:0072523 | Colorectum | AD | purine-containing compound catabolic process | 19/3918 | 52/18723 | 6.92e-03 | 4.26e-02 | 19 |
GO:00061631 | Colorectum | SER | purine nucleotide metabolic process | 109/2897 | 396/18723 | 4.26e-10 | 5.44e-08 | 109 |
GO:00091501 | Colorectum | SER | purine ribonucleotide metabolic process | 103/2897 | 368/18723 | 4.69e-10 | 5.68e-08 | 103 |
GO:00725211 | Colorectum | SER | purine-containing compound metabolic process | 113/2897 | 416/18723 | 4.80e-10 | 5.68e-08 | 113 |
GO:00092591 | Colorectum | SER | ribonucleotide metabolic process | 104/2897 | 385/18723 | 3.27e-09 | 3.04e-07 | 104 |
GO:00196931 | Colorectum | SER | ribose phosphate metabolic process | 105/2897 | 396/18723 | 8.15e-09 | 7.14e-07 | 105 |
GO:00091171 | Colorectum | SER | nucleotide metabolic process | 122/2897 | 489/18723 | 2.50e-08 | 1.76e-06 | 122 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04928 | Colorectum | AD | Parathyroid hormone synthesis, secretion and action | 38/2092 | 106/8465 | 6.60e-03 | 2.77e-02 | 1.76e-02 | 38 |
hsa049281 | Colorectum | AD | Parathyroid hormone synthesis, secretion and action | 38/2092 | 106/8465 | 6.60e-03 | 2.77e-02 | 1.76e-02 | 38 |
hsa049282 | Colorectum | SER | Parathyroid hormone synthesis, secretion and action | 31/1580 | 106/8465 | 5.20e-03 | 3.28e-02 | 2.38e-02 | 31 |
hsa049283 | Colorectum | SER | Parathyroid hormone synthesis, secretion and action | 31/1580 | 106/8465 | 5.20e-03 | 3.28e-02 | 2.38e-02 | 31 |
hsa0492816 | Esophagus | ESCC | Parathyroid hormone synthesis, secretion and action | 66/4205 | 106/8465 | 5.86e-03 | 1.47e-02 | 7.51e-03 | 66 |
hsa0492817 | Esophagus | ESCC | Parathyroid hormone synthesis, secretion and action | 66/4205 | 106/8465 | 5.86e-03 | 1.47e-02 | 7.51e-03 | 66 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDE4C | SNV | Missense_Mutation | c.1895N>C | p.Glu632Ala | p.E632A | Q08493 | protein_coding | tolerated(0.08) | benign(0.007) | TCGA-HF-7132-01 | Stomach | stomach adenocarcinoma | Male | Unknown | I/II | Chemotherapy | fluorouracil | SD | |
PDE4C | SNV | Missense_Mutation | rs750056384 | c.487N>T | p.Arg163Trp | p.R163W | Q08493 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-HF-7132-01 | Stomach | stomach adenocarcinoma | Male | Unknown | I/II | Chemotherapy | fluorouracil | SD |
PDE4C | SNV | Missense_Mutation | novel | c.2096G>A | p.Gly699Asp | p.G699D | Q08493 | protein_coding | tolerated_low_confidence(0.25) | benign(0.003) | TCGA-R5-A7ZI-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PDE4C | SNV | Missense_Mutation | rs764071894 | c.1568T>G | p.Leu523Arg | p.L523R | Q08493 | protein_coding | tolerated(0.07) | probably_damaging(0.949) | TCGA-VQ-A8PU-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5143 | PDE4C | DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL1200434 | OXTRIPHYLLINE | |
5143 | PDE4C | DRUGGABLE GENOME, ENZYME | inhibitor | 178101942 | ||
5143 | PDE4C | DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL1752 | DYPHYLLINE | |
5143 | PDE4C | DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL1096 | AMLEXANOX | |
5143 | PDE4C | DRUGGABLE GENOME, ENZYME | inhibitor | 178103971 | IBUDILAST | |
5143 | PDE4C | DRUGGABLE GENOME, ENZYME | inhibitor | 178103944 | APREMILAST | |
5143 | PDE4C | DRUGGABLE GENOME, ENZYME | inhibitor | 363894172 | ||
5143 | PDE4C | DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL932 | DIPYRIDAMOLE | |
5143 | PDE4C | DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL193240 | ROFLUMILAST | |
5143 | PDE4C | DRUGGABLE GENOME, ENZYME | inhibitor | 363894146 |
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