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Gene: PACS2 |
Gene summary for PACS2 |
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Gene information | Species | Human | Gene symbol | PACS2 | Gene ID | 23241 |
Gene name | phosphofurin acidic cluster sorting protein 2 | |
Gene Alias | DEE66 | |
Cytomap | 14q32.33 | |
Gene Type | protein-coding | GO ID | GO:0000045 | UniProtAcc | Q86VP3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23241 | PACS2 | LZE20T | Human | Esophagus | ESCC | 3.40e-03 | 1.86e-01 | 0.0662 |
23241 | PACS2 | LZE24T | Human | Esophagus | ESCC | 2.75e-06 | 1.82e-01 | 0.0596 |
23241 | PACS2 | P1T-E | Human | Esophagus | ESCC | 3.38e-12 | 4.04e-01 | 0.0875 |
23241 | PACS2 | P4T-E | Human | Esophagus | ESCC | 2.31e-05 | 1.13e-01 | 0.1323 |
23241 | PACS2 | P5T-E | Human | Esophagus | ESCC | 5.00e-12 | 2.76e-01 | 0.1327 |
23241 | PACS2 | P8T-E | Human | Esophagus | ESCC | 3.23e-14 | 2.30e-01 | 0.0889 |
23241 | PACS2 | P10T-E | Human | Esophagus | ESCC | 3.89e-16 | 2.71e-01 | 0.116 |
23241 | PACS2 | P12T-E | Human | Esophagus | ESCC | 2.76e-08 | 2.12e-01 | 0.1122 |
23241 | PACS2 | P15T-E | Human | Esophagus | ESCC | 1.91e-17 | 4.09e-01 | 0.1149 |
23241 | PACS2 | P16T-E | Human | Esophagus | ESCC | 1.15e-04 | 2.61e-02 | 0.1153 |
23241 | PACS2 | P21T-E | Human | Esophagus | ESCC | 9.64e-06 | 1.03e-01 | 0.1617 |
23241 | PACS2 | P22T-E | Human | Esophagus | ESCC | 1.13e-05 | 9.69e-02 | 0.1236 |
23241 | PACS2 | P23T-E | Human | Esophagus | ESCC | 2.34e-04 | 8.27e-02 | 0.108 |
23241 | PACS2 | P24T-E | Human | Esophagus | ESCC | 5.97e-05 | 9.60e-02 | 0.1287 |
23241 | PACS2 | P26T-E | Human | Esophagus | ESCC | 9.82e-10 | 1.32e-01 | 0.1276 |
23241 | PACS2 | P27T-E | Human | Esophagus | ESCC | 4.11e-19 | 2.19e-01 | 0.1055 |
23241 | PACS2 | P28T-E | Human | Esophagus | ESCC | 1.98e-13 | 2.56e-01 | 0.1149 |
23241 | PACS2 | P30T-E | Human | Esophagus | ESCC | 5.93e-04 | 2.38e-01 | 0.137 |
23241 | PACS2 | P31T-E | Human | Esophagus | ESCC | 9.49e-08 | 1.55e-01 | 0.1251 |
23241 | PACS2 | P32T-E | Human | Esophagus | ESCC | 1.25e-06 | 1.18e-01 | 0.1666 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001623617 | Esophagus | ESCC | macroautophagy | 216/8552 | 291/18723 | 1.94e-23 | 4.57e-21 | 216 |
GO:0072659110 | Esophagus | ESCC | protein localization to plasma membrane | 193/8552 | 284/18723 | 1.95e-14 | 1.03e-12 | 193 |
GO:199077819 | Esophagus | ESCC | protein localization to cell periphery | 217/8552 | 333/18723 | 4.08e-13 | 1.88e-11 | 217 |
GO:000703314 | Esophagus | ESCC | vacuole organization | 127/8552 | 180/18723 | 1.04e-11 | 3.85e-10 | 127 |
GO:190503712 | Esophagus | ESCC | autophagosome organization | 73/8552 | 103/18723 | 1.88e-07 | 2.93e-06 | 73 |
GO:00224069 | Esophagus | ESCC | membrane docking | 62/8552 | 86/18723 | 5.93e-07 | 7.79e-06 | 62 |
GO:000004513 | Esophagus | ESCC | autophagosome assembly | 69/8552 | 99/18723 | 1.10e-06 | 1.38e-05 | 69 |
GO:01400567 | Esophagus | ESCC | organelle localization by membrane tethering | 53/8552 | 77/18723 | 3.33e-05 | 2.74e-04 | 53 |
GO:0032469110 | Esophagus | ESCC | endoplasmic reticulum calcium ion homeostasis | 21/8552 | 25/18723 | 9.12e-05 | 6.54e-04 | 21 |
GO:00726597 | Liver | NAFLD | protein localization to plasma membrane | 51/1882 | 284/18723 | 2.97e-05 | 7.83e-04 | 51 |
GO:19907786 | Liver | NAFLD | protein localization to cell periphery | 56/1882 | 333/18723 | 8.29e-05 | 1.69e-03 | 56 |
GO:00162365 | Liver | NAFLD | macroautophagy | 45/1882 | 291/18723 | 2.31e-03 | 2.19e-02 | 45 |
GO:001623621 | Liver | HCC | macroautophagy | 204/7958 | 291/18723 | 8.66e-22 | 1.41e-19 | 204 |
GO:007265921 | Liver | HCC | protein localization to plasma membrane | 177/7958 | 284/18723 | 1.02e-11 | 4.18e-10 | 177 |
GO:199077821 | Liver | HCC | protein localization to cell periphery | 200/7958 | 333/18723 | 6.07e-11 | 2.23e-09 | 200 |
GO:000703311 | Liver | HCC | vacuole organization | 119/7958 | 180/18723 | 1.22e-10 | 4.25e-09 | 119 |
GO:19050371 | Liver | HCC | autophagosome organization | 70/7958 | 103/18723 | 1.52e-07 | 2.82e-06 | 70 |
GO:00000451 | Liver | HCC | autophagosome assembly | 67/7958 | 99/18723 | 3.56e-07 | 6.07e-06 | 67 |
GO:002240611 | Liver | HCC | membrane docking | 57/7958 | 86/18723 | 7.14e-06 | 8.47e-05 | 57 |
GO:014005611 | Liver | HCC | organelle localization by membrane tethering | 49/7958 | 77/18723 | 1.46e-04 | 1.18e-03 | 49 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PACS2 | SNV | Missense_Mutation | novel | c.655G>T | p.Gly219Trp | p.G219W | Q86VP3 | protein_coding | tolerated(0.05) | benign(0.287) | TCGA-85-8048-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PACS2 | SNV | Missense_Mutation | rs145923328 | c.713N>T | p.Ser238Leu | p.S238L | Q86VP3 | protein_coding | tolerated(0.2) | benign(0.103) | TCGA-90-A4ED-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PACS2 | SNV | Missense_Mutation | novel | c.655N>A | p.Gly219Arg | p.G219R | Q86VP3 | protein_coding | tolerated(0.17) | possibly_damaging(0.452) | TCGA-92-7341-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PACS2 | deletion | In_Frame_Del | novel | c.122_130delNNNNNNNNN | p.Cys42_Leu44del | p.C42_L44del | Q86VP3 | protein_coding | TCGA-49-6742-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | alimta | PD | ||
PACS2 | deletion | In_Frame_Del | c.288_290delNNN | p.Ser97del | p.S97del | Q86VP3 | protein_coding | TCGA-86-A4JF-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | unknown | PD | |||
PACS2 | deletion | In_Frame_Del | c.290_292delCCT | p.Ser97del | p.S97del | Q86VP3 | protein_coding | TCGA-63-A5MM-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |||
PACS2 | deletion | In_Frame_Del | c.288_290delNNN | p.Ser97del | p.S97del | Q86VP3 | protein_coding | TCGA-77-8150-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |||
PACS2 | SNV | Missense_Mutation | novel | c.1836C>G | p.Phe612Leu | p.F612L | Q86VP3 | protein_coding | tolerated(0.99) | benign(0.001) | TCGA-BA-5558-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PACS2 | SNV | Missense_Mutation | novel | c.1717G>A | p.Glu573Lys | p.E573K | Q86VP3 | protein_coding | tolerated(0.14) | possibly_damaging(0.477) | TCGA-CN-6998-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
PACS2 | SNV | Missense_Mutation | novel | c.1571N>T | p.Ser524Phe | p.S524F | Q86VP3 | protein_coding | tolerated(0.1) | benign(0.328) | TCGA-CQ-5334-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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