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Gene: OSBPL3 |
Gene summary for OSBPL3 |
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Gene information | Species | Human | Gene symbol | OSBPL3 | Gene ID | 26031 |
Gene name | oxysterol binding protein like 3 | |
Gene Alias | ORP-3 | |
Cytomap | 7p15.3 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | Q9H4L5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26031 | OSBPL3 | CCI_1 | Human | Cervix | CC | 2.20e-05 | 1.05e+00 | 0.528 |
26031 | OSBPL3 | CCI_2 | Human | Cervix | CC | 4.39e-09 | 1.13e+00 | 0.5249 |
26031 | OSBPL3 | CCI_3 | Human | Cervix | CC | 4.68e-13 | 8.41e-01 | 0.516 |
26031 | OSBPL3 | H2 | Human | Cervix | HSIL_HPV | 4.84e-04 | 3.11e-01 | 0.0632 |
26031 | OSBPL3 | AEH-subject1 | Human | Endometrium | AEH | 1.50e-25 | 5.71e-01 | -0.3059 |
26031 | OSBPL3 | AEH-subject2 | Human | Endometrium | AEH | 1.01e-13 | 4.72e-01 | -0.2525 |
26031 | OSBPL3 | AEH-subject3 | Human | Endometrium | AEH | 4.19e-07 | 3.07e-01 | -0.2576 |
26031 | OSBPL3 | AEH-subject4 | Human | Endometrium | AEH | 3.42e-19 | 6.75e-01 | -0.2657 |
26031 | OSBPL3 | AEH-subject5 | Human | Endometrium | AEH | 5.10e-21 | 5.03e-01 | -0.2953 |
26031 | OSBPL3 | EEC-subject2 | Human | Endometrium | EEC | 5.20e-06 | 3.19e-01 | -0.2607 |
26031 | OSBPL3 | EEC-subject5 | Human | Endometrium | EEC | 3.06e-11 | 4.14e-01 | -0.249 |
26031 | OSBPL3 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 4.50e-05 | 1.54e-01 | -0.1875 |
26031 | OSBPL3 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 5.76e-03 | 1.29e-01 | -0.1916 |
26031 | OSBPL3 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 1.40e-13 | 4.50e-01 | -0.1269 |
26031 | OSBPL3 | LZE4T | Human | Esophagus | ESCC | 3.31e-07 | 1.06e-01 | 0.0811 |
26031 | OSBPL3 | LZE7T | Human | Esophagus | ESCC | 1.42e-05 | 1.26e-01 | 0.0667 |
26031 | OSBPL3 | LZE20T | Human | Esophagus | ESCC | 1.51e-04 | 1.42e-01 | 0.0662 |
26031 | OSBPL3 | LZE24T | Human | Esophagus | ESCC | 3.67e-12 | 1.65e-01 | 0.0596 |
26031 | OSBPL3 | LZE6T | Human | Esophagus | ESCC | 1.08e-04 | 1.64e-01 | 0.0845 |
26031 | OSBPL3 | P1T-E | Human | Esophagus | ESCC | 3.51e-06 | 2.78e-01 | 0.0875 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00463948 | Esophagus | ESCC | carboxylic acid biosynthetic process | 175/8552 | 314/18723 | 1.98e-04 | 1.26e-03 | 175 |
GO:00160538 | Esophagus | ESCC | organic acid biosynthetic process | 175/8552 | 316/18723 | 3.04e-04 | 1.82e-03 | 175 |
GO:00066946 | Esophagus | ESCC | steroid biosynthetic process | 98/8552 | 173/18723 | 2.34e-03 | 1.03e-02 | 98 |
GO:19016174 | Esophagus | ESCC | organic hydroxy compound biosynthetic process | 128/8552 | 237/18723 | 5.86e-03 | 2.16e-02 | 128 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
OSBPL3 | SNV | Missense_Mutation | c.108N>T | p.Glu36Asp | p.E36D | Q9H4L5 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-67-3771-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
OSBPL3 | SNV | Missense_Mutation | c.2386N>C | p.Asp796His | p.D796H | Q9H4L5 | protein_coding | deleterious(0.04) | probably_damaging(0.992) | TCGA-69-7980-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
OSBPL3 | SNV | Missense_Mutation | c.850G>C | p.Asp284His | p.D284H | Q9H4L5 | protein_coding | deleterious(0.02) | possibly_damaging(0.761) | TCGA-78-7156-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
OSBPL3 | SNV | Missense_Mutation | novel | c.1044G>T | p.Arg348Ser | p.R348S | Q9H4L5 | protein_coding | tolerated(0.28) | benign(0.009) | TCGA-86-8056-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
OSBPL3 | SNV | Missense_Mutation | c.148G>C | p.Glu50Gln | p.E50Q | Q9H4L5 | protein_coding | tolerated(0.21) | probably_damaging(0.971) | TCGA-86-8358-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
OSBPL3 | SNV | Missense_Mutation | c.1857N>A | p.Asp619Glu | p.D619E | Q9H4L5 | protein_coding | tolerated(0.11) | benign(0.248) | TCGA-MP-A4TA-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
OSBPL3 | SNV | Missense_Mutation | novel | c.1986N>T | p.Met662Ile | p.M662I | Q9H4L5 | protein_coding | deleterious(0.05) | benign(0.047) | TCGA-33-AASB-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
OSBPL3 | SNV | Missense_Mutation | novel | c.86N>T | p.Gly29Val | p.G29V | Q9H4L5 | protein_coding | tolerated(0.31) | probably_damaging(0.964) | TCGA-39-5040-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | PD |
OSBPL3 | SNV | Missense_Mutation | c.1372C>G | p.Leu458Val | p.L458V | Q9H4L5 | protein_coding | tolerated(0.05) | probably_damaging(0.998) | TCGA-60-2713-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | gemzar | SD | |
OSBPL3 | SNV | Missense_Mutation | rs769314791 | c.1627N>T | p.Val543Leu | p.V543L | Q9H4L5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-66-2756-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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