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Gene: OSBP |
Gene summary for OSBP |
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Gene information | Species | Human | Gene symbol | OSBP | Gene ID | 5007 |
Gene name | oxysterol binding protein | |
Gene Alias | OSBP1 | |
Cytomap | 11q12.1 | |
Gene Type | protein-coding | GO ID | GO:0001678 | UniProtAcc | P22059 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5007 | OSBP | HTA11_347_2000001011 | Human | Colorectum | AD | 3.24e-07 | 3.84e-01 | -0.1954 |
5007 | OSBP | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.97e-02 | 3.87e-01 | 0.294 |
5007 | OSBP | HTA11_99999965104_69814 | Human | Colorectum | MSS | 6.45e-03 | 2.53e-01 | 0.281 |
5007 | OSBP | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.80e-02 | 4.11e-01 | 0.3859 |
5007 | OSBP | A015-C-203 | Human | Colorectum | FAP | 1.07e-08 | -1.67e-01 | -0.1294 |
5007 | OSBP | A001-C-108 | Human | Colorectum | FAP | 3.31e-04 | -2.78e-03 | -0.0272 |
5007 | OSBP | A002-C-205 | Human | Colorectum | FAP | 2.21e-04 | -1.52e-01 | -0.1236 |
5007 | OSBP | A015-C-006 | Human | Colorectum | FAP | 2.70e-02 | -9.12e-02 | -0.0994 |
5007 | OSBP | A002-C-114 | Human | Colorectum | FAP | 4.09e-03 | -9.21e-02 | -0.1561 |
5007 | OSBP | A015-C-104 | Human | Colorectum | FAP | 2.06e-08 | -5.46e-02 | -0.1899 |
5007 | OSBP | A001-C-014 | Human | Colorectum | FAP | 5.91e-06 | -1.63e-01 | 0.0135 |
5007 | OSBP | A002-C-016 | Human | Colorectum | FAP | 1.74e-05 | -1.51e-01 | 0.0521 |
5007 | OSBP | A002-C-116 | Human | Colorectum | FAP | 1.81e-08 | -9.00e-02 | -0.0452 |
5007 | OSBP | A018-E-020 | Human | Colorectum | FAP | 3.18e-04 | -1.63e-01 | -0.2034 |
5007 | OSBP | F034 | Human | Colorectum | FAP | 1.27e-04 | -1.35e-01 | -0.0665 |
5007 | OSBP | F072B | Human | Colorectum | FAP | 1.01e-02 | -1.24e-01 | 0.257 |
5007 | OSBP | LZE4T | Human | Esophagus | ESCC | 6.27e-04 | 9.86e-02 | 0.0811 |
5007 | OSBP | LZE7T | Human | Esophagus | ESCC | 3.98e-04 | 1.35e-01 | 0.0667 |
5007 | OSBP | LZE24T | Human | Esophagus | ESCC | 1.28e-13 | 2.83e-01 | 0.0596 |
5007 | OSBP | P2T-E | Human | Esophagus | ESCC | 1.91e-11 | 1.31e-01 | 0.1177 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00512359 | Cervix | CC | maintenance of location | 78/2311 | 327/18723 | 5.18e-09 | 4.92e-07 | 78 |
GO:003367410 | Cervix | CC | positive regulation of kinase activity | 101/2311 | 467/18723 | 8.66e-09 | 7.22e-07 | 101 |
GO:00458608 | Cervix | CC | positive regulation of protein kinase activity | 85/2311 | 386/18723 | 5.61e-08 | 3.29e-06 | 85 |
GO:00345048 | Cervix | CC | protein localization to nucleus | 68/2311 | 290/18723 | 9.91e-08 | 5.25e-06 | 68 |
GO:00454445 | Cervix | CC | fat cell differentiation | 53/2311 | 229/18723 | 3.72e-06 | 9.75e-05 | 53 |
GO:19016538 | Cervix | CC | cellular response to peptide | 72/2311 | 359/18723 | 1.89e-05 | 3.48e-04 | 72 |
GO:00512713 | Cervix | CC | negative regulation of cellular component movement | 73/2311 | 367/18723 | 2.22e-05 | 3.95e-04 | 73 |
GO:00400133 | Cervix | CC | negative regulation of locomotion | 76/2311 | 391/18723 | 3.47e-05 | 5.60e-04 | 76 |
GO:20001463 | Cervix | CC | negative regulation of cell motility | 71/2311 | 359/18723 | 3.47e-05 | 5.60e-04 | 71 |
GO:00303363 | Cervix | CC | negative regulation of cell migration | 68/2311 | 344/18723 | 5.11e-05 | 7.70e-04 | 68 |
GO:00434349 | Cervix | CC | response to peptide hormone | 77/2311 | 414/18723 | 1.40e-04 | 1.70e-03 | 77 |
GO:00713757 | Cervix | CC | cellular response to peptide hormone stimulus | 57/2311 | 290/18723 | 2.32e-04 | 2.59e-03 | 57 |
GO:00328698 | Cervix | CC | cellular response to insulin stimulus | 42/2311 | 203/18723 | 4.95e-04 | 4.83e-03 | 42 |
GO:00518964 | Cervix | CC | regulation of protein kinase B signaling | 39/2311 | 185/18723 | 5.25e-04 | 5.10e-03 | 39 |
GO:00518973 | Cervix | CC | positive regulation of protein kinase B signaling | 28/2311 | 120/18723 | 5.90e-04 | 5.59e-03 | 28 |
GO:00434913 | Cervix | CC | protein kinase B signaling | 43/2311 | 211/18723 | 5.95e-04 | 5.60e-03 | 43 |
GO:00328688 | Cervix | CC | response to insulin | 50/2311 | 264/18723 | 1.28e-03 | 1.02e-02 | 50 |
GO:00108834 | Cervix | CC | regulation of lipid storage | 15/2311 | 57/18723 | 3.13e-03 | 2.05e-02 | 15 |
GO:00082865 | Cervix | CC | insulin receptor signaling pathway | 25/2311 | 116/18723 | 3.59e-03 | 2.30e-02 | 25 |
GO:00347645 | Cervix | CC | positive regulation of transmembrane transport | 40/2311 | 219/18723 | 6.97e-03 | 3.76e-02 | 40 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
OSBP | SNV | Missense_Mutation | c.634N>T | p.Arg212Trp | p.R212W | P22059 | protein_coding | deleterious(0) | probably_damaging(0.952) | TCGA-HU-8243-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |
OSBP | SNV | Missense_Mutation | c.2146N>T | p.Arg716Trp | p.R716W | P22059 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-HU-8608-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | doxifluridine | PD | |
OSBP | SNV | Missense_Mutation | c.2347T>G | p.Leu783Val | p.L783V | P22059 | protein_coding | tolerated(0.47) | benign(0.007) | TCGA-HU-A4GH-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
OSBP | SNV | Missense_Mutation | rs765435028 | c.2182C>T | p.Arg728Cys | p.R728C | P22059 | protein_coding | tolerated(0.07) | benign(0.055) | TCGA-VQ-A8E7-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
OSBP | SNV | Missense_Mutation | novel | c.1054G>A | p.Asp352Asn | p.D352N | P22059 | protein_coding | deleterious(0.04) | possibly_damaging(0.82) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
OSBP | SNV | Missense_Mutation | novel | c.358N>C | p.Tyr120His | p.Y120H | P22059 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-VQ-A8PX-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
OSBP | deletion | Frame_Shift_Del | novel | c.718_719delNN | p.Ser240Ter | p.S240* | P22059 | protein_coding | TCGA-BR-8361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
OSBP | SNV | Missense_Mutation | c.458N>G | p.Asn153Ser | p.N153S | P22059 | protein_coding | tolerated(0.47) | benign(0.402) | TCGA-BJ-A28X-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
OSBP | SNV | Missense_Mutation | novel | c.2060C>A | p.Pro687Gln | p.P687Q | P22059 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-E8-A2EA-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
OSBP | insertion | Frame_Shift_Ins | novel | c.1248_1249insAG | p.Leu417SerfsTer8 | p.L417Sfs*8 | P22059 | protein_coding | TCGA-BJ-A45E-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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