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Gene: NXPE3 |
Gene summary for NXPE3 |
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Gene information | Species | Human | Gene symbol | NXPE3 | Gene ID | 91775 |
Gene name | neurexophilin and PC-esterase domain family member 3 | |
Gene Alias | FAM55C | |
Cytomap | 3q12.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q969Y0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
91775 | NXPE3 | LZE2T | Human | Esophagus | ESCC | 4.73e-03 | 2.90e-01 | 0.082 |
91775 | NXPE3 | LZE4T | Human | Esophagus | ESCC | 7.96e-15 | 4.31e-01 | 0.0811 |
91775 | NXPE3 | LZE22T | Human | Esophagus | ESCC | 1.28e-07 | 4.22e-01 | 0.068 |
91775 | NXPE3 | LZE24T | Human | Esophagus | ESCC | 1.09e-06 | 1.59e-01 | 0.0596 |
91775 | NXPE3 | P2T-E | Human | Esophagus | ESCC | 3.11e-16 | 2.95e-01 | 0.1177 |
91775 | NXPE3 | P4T-E | Human | Esophagus | ESCC | 1.75e-05 | 1.38e-01 | 0.1323 |
91775 | NXPE3 | P5T-E | Human | Esophagus | ESCC | 4.32e-08 | 1.69e-01 | 0.1327 |
91775 | NXPE3 | P8T-E | Human | Esophagus | ESCC | 2.17e-10 | 1.80e-01 | 0.0889 |
91775 | NXPE3 | P9T-E | Human | Esophagus | ESCC | 3.67e-14 | 3.20e-01 | 0.1131 |
91775 | NXPE3 | P10T-E | Human | Esophagus | ESCC | 1.92e-31 | 5.22e-01 | 0.116 |
91775 | NXPE3 | P11T-E | Human | Esophagus | ESCC | 2.06e-07 | 2.62e-01 | 0.1426 |
91775 | NXPE3 | P12T-E | Human | Esophagus | ESCC | 1.71e-04 | 1.23e-01 | 0.1122 |
91775 | NXPE3 | P15T-E | Human | Esophagus | ESCC | 9.51e-20 | 3.97e-01 | 0.1149 |
91775 | NXPE3 | P16T-E | Human | Esophagus | ESCC | 1.19e-16 | 2.70e-01 | 0.1153 |
91775 | NXPE3 | P19T-E | Human | Esophagus | ESCC | 3.75e-07 | 3.87e-01 | 0.1662 |
91775 | NXPE3 | P20T-E | Human | Esophagus | ESCC | 2.32e-06 | 1.59e-01 | 0.1124 |
91775 | NXPE3 | P21T-E | Human | Esophagus | ESCC | 5.97e-22 | 4.96e-01 | 0.1617 |
91775 | NXPE3 | P22T-E | Human | Esophagus | ESCC | 8.01e-24 | 4.76e-01 | 0.1236 |
91775 | NXPE3 | P23T-E | Human | Esophagus | ESCC | 7.44e-14 | 3.44e-01 | 0.108 |
91775 | NXPE3 | P24T-E | Human | Esophagus | ESCC | 2.83e-07 | 1.51e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NXPE3 | SNV | Missense_Mutation | c.998N>T | p.Pro333Leu | p.P333L | Q969Y0 | protein_coding | tolerated(0.09) | benign(0.118) | TCGA-CG-5723-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NXPE3 | SNV | Missense_Mutation | rs139135706 | c.1277N>T | p.Ala426Val | p.A426V | Q969Y0 | protein_coding | deleterious(0) | probably_damaging(0.951) | TCGA-HF-7132-01 | Stomach | stomach adenocarcinoma | Male | Unknown | I/II | Chemotherapy | fluorouracil | SD |
NXPE3 | SNV | Missense_Mutation | c.302C>T | p.Thr101Ile | p.T101I | Q969Y0 | protein_coding | deleterious(0) | possibly_damaging(0.835) | TCGA-HU-A4HD-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
NXPE3 | SNV | Missense_Mutation | rs760288885 | c.1016G>A | p.Arg339His | p.R339H | Q969Y0 | protein_coding | tolerated(0.69) | benign(0) | TCGA-MX-A666-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | epirubicin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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