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Gene: NR4A2 |
Gene summary for NR4A2 |
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Gene information | Species | Human | Gene symbol | NR4A2 | Gene ID | 4929 |
Gene name | nuclear receptor subfamily 4 group A member 2 | |
Gene Alias | HZF-3 | |
Cytomap | 2q24.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | F1D8N6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4929 | NR4A2 | GSM4909282 | Human | Breast | IDC | 2.79e-12 | 6.24e-01 | -0.0288 |
4929 | NR4A2 | GSM4909286 | Human | Breast | IDC | 5.57e-04 | 1.19e-01 | 0.1081 |
4929 | NR4A2 | GSM4909291 | Human | Breast | IDC | 2.96e-03 | 3.82e-01 | 0.1753 |
4929 | NR4A2 | GSM4909294 | Human | Breast | IDC | 2.27e-02 | -2.11e-01 | 0.2022 |
4929 | NR4A2 | GSM4909297 | Human | Breast | IDC | 7.30e-03 | -1.60e-01 | 0.1517 |
4929 | NR4A2 | GSM4909298 | Human | Breast | IDC | 2.71e-02 | -2.30e-01 | 0.1551 |
4929 | NR4A2 | GSM4909304 | Human | Breast | IDC | 2.07e-02 | -2.05e-01 | 0.1636 |
4929 | NR4A2 | GSM4909308 | Human | Breast | IDC | 2.11e-34 | 7.85e-01 | 0.158 |
4929 | NR4A2 | GSM4909311 | Human | Breast | IDC | 6.16e-11 | -2.79e-01 | 0.1534 |
4929 | NR4A2 | GSM4909313 | Human | Breast | IDC | 3.13e-02 | 3.03e-01 | 0.0391 |
4929 | NR4A2 | GSM4909319 | Human | Breast | IDC | 1.90e-09 | -2.39e-01 | 0.1563 |
4929 | NR4A2 | GSM4909320 | Human | Breast | IDC | 4.54e-03 | -3.17e-01 | 0.1575 |
4929 | NR4A2 | GSM4909321 | Human | Breast | IDC | 3.04e-03 | -2.14e-01 | 0.1559 |
4929 | NR4A2 | brca1 | Human | Breast | Precancer | 4.83e-06 | -2.88e-01 | -0.0338 |
4929 | NR4A2 | brca2 | Human | Breast | Precancer | 1.56e-05 | -2.67e-01 | -0.024 |
4929 | NR4A2 | brca3 | Human | Breast | Precancer | 1.10e-04 | -2.82e-01 | -0.0263 |
4929 | NR4A2 | brca10 | Human | Breast | Precancer | 1.20e-05 | -2.88e-01 | -0.0029 |
4929 | NR4A2 | NCCBC14 | Human | Breast | DCIS | 1.73e-06 | -2.86e-01 | 0.2021 |
4929 | NR4A2 | NCCBC3 | Human | Breast | DCIS | 1.44e-04 | -2.62e-01 | 0.1198 |
4929 | NR4A2 | NCCBC5 | Human | Breast | DCIS | 2.45e-04 | -1.96e-01 | 0.2046 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:20012339 | Breast | Precancer | regulation of apoptotic signaling pathway | 65/1080 | 356/18723 | 7.70e-17 | 3.17e-14 | 65 |
GO:00069799 | Breast | Precancer | response to oxidative stress | 70/1080 | 446/18723 | 1.59e-14 | 4.26e-12 | 70 |
GO:00362939 | Breast | Precancer | response to decreased oxygen levels | 53/1080 | 322/18723 | 4.09e-12 | 6.84e-10 | 53 |
GO:00016669 | Breast | Precancer | response to hypoxia | 51/1080 | 307/18723 | 7.33e-12 | 1.11e-09 | 51 |
GO:00704829 | Breast | Precancer | response to oxygen levels | 55/1080 | 347/18723 | 7.47e-12 | 1.11e-09 | 55 |
GO:00621979 | Breast | Precancer | cellular response to chemical stress | 51/1080 | 337/18723 | 2.40e-10 | 2.34e-08 | 51 |
GO:20012349 | Breast | Precancer | negative regulation of apoptotic signaling pathway | 39/1080 | 224/18723 | 5.35e-10 | 4.77e-08 | 39 |
GO:00709979 | Breast | Precancer | neuron death | 50/1080 | 361/18723 | 7.75e-09 | 5.70e-07 | 50 |
GO:00514029 | Breast | Precancer | neuron apoptotic process | 38/1080 | 246/18723 | 2.68e-08 | 1.75e-06 | 38 |
GO:00345999 | Breast | Precancer | cellular response to oxidative stress | 42/1080 | 288/18723 | 2.78e-08 | 1.79e-06 | 42 |
GO:00309018 | Breast | Precancer | midbrain development | 20/1080 | 90/18723 | 1.50e-07 | 7.93e-06 | 20 |
GO:19012149 | Breast | Precancer | regulation of neuron death | 41/1080 | 319/18723 | 1.27e-06 | 4.80e-05 | 41 |
GO:00435237 | Breast | Precancer | regulation of neuron apoptotic process | 31/1080 | 212/18723 | 1.69e-06 | 6.08e-05 | 31 |
GO:00435243 | Breast | Precancer | negative regulation of neuron apoptotic process | 19/1080 | 145/18723 | 6.83e-04 | 8.34e-03 | 19 |
GO:00454444 | Breast | Precancer | fat cell differentiation | 26/1080 | 229/18723 | 7.60e-04 | 9.04e-03 | 26 |
GO:00714969 | Breast | Precancer | cellular response to external stimulus | 33/1080 | 320/18723 | 9.01e-04 | 1.03e-02 | 33 |
GO:19012157 | Breast | Precancer | negative regulation of neuron death | 24/1080 | 208/18723 | 9.50e-04 | 1.07e-02 | 24 |
GO:00316688 | Breast | Precancer | cellular response to extracellular stimulus | 27/1080 | 246/18723 | 1.02e-03 | 1.13e-02 | 27 |
GO:00140753 | Breast | Precancer | response to amine | 9/1080 | 49/18723 | 1.74e-03 | 1.74e-02 | 9 |
GO:0001975 | Breast | Precancer | response to amphetamine | 7/1080 | 33/18723 | 2.37e-03 | 2.19e-02 | 7 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0492812 | Cervix | CC | Parathyroid hormone synthesis, secretion and action | 27/1267 | 106/8465 | 3.12e-03 | 1.19e-02 | 7.03e-03 | 27 |
hsa0492813 | Cervix | CC | Parathyroid hormone synthesis, secretion and action | 27/1267 | 106/8465 | 3.12e-03 | 1.19e-02 | 7.03e-03 | 27 |
hsa0492816 | Esophagus | ESCC | Parathyroid hormone synthesis, secretion and action | 66/4205 | 106/8465 | 5.86e-03 | 1.47e-02 | 7.51e-03 | 66 |
hsa0492817 | Esophagus | ESCC | Parathyroid hormone synthesis, secretion and action | 66/4205 | 106/8465 | 5.86e-03 | 1.47e-02 | 7.51e-03 | 66 |
hsa0492810 | Lung | IAC | Parathyroid hormone synthesis, secretion and action | 26/1053 | 106/8465 | 4.34e-04 | 4.03e-03 | 2.68e-03 | 26 |
hsa0492811 | Lung | IAC | Parathyroid hormone synthesis, secretion and action | 26/1053 | 106/8465 | 4.34e-04 | 4.03e-03 | 2.68e-03 | 26 |
hsa0492814 | Prostate | BPH | Parathyroid hormone synthesis, secretion and action | 33/1718 | 106/8465 | 5.30e-03 | 1.75e-02 | 1.08e-02 | 33 |
hsa0492815 | Prostate | BPH | Parathyroid hormone synthesis, secretion and action | 33/1718 | 106/8465 | 5.30e-03 | 1.75e-02 | 1.08e-02 | 33 |
hsa0492822 | Prostate | Tumor | Parathyroid hormone synthesis, secretion and action | 35/1791 | 106/8465 | 2.89e-03 | 1.07e-02 | 6.67e-03 | 35 |
hsa0492832 | Prostate | Tumor | Parathyroid hormone synthesis, secretion and action | 35/1791 | 106/8465 | 2.89e-03 | 1.07e-02 | 6.67e-03 | 35 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NR4A2 | insertion | Frame_Shift_Ins | novel | c.247_248insA | p.Leu83HisfsTer9 | p.L83Hfs*9 | P43354 | protein_coding | TCGA-EY-A5W2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
NR4A2 | SNV | Missense_Mutation | c.40N>A | p.Gly14Arg | p.G14R | P43354 | protein_coding | deleterious(0.01) | probably_damaging(0.923) | TCGA-CC-5263-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
NR4A2 | SNV | Missense_Mutation | c.40G>A | p.Gly14Arg | p.G14R | P43354 | protein_coding | deleterious(0.01) | probably_damaging(0.923) | TCGA-DD-A1EE-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
NR4A2 | SNV | Missense_Mutation | novel | c.461N>T | p.Gln154Leu | p.Q154L | P43354 | protein_coding | tolerated(0.18) | benign(0.031) | TCGA-RC-A6M4-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
NR4A2 | SNV | Missense_Mutation | c.398N>T | p.Pro133Leu | p.P133L | P43354 | protein_coding | deleterious(0) | possibly_damaging(0.855) | TCGA-UB-A7MF-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
NR4A2 | SNV | Missense_Mutation | c.611C>A | p.Pro204Gln | p.P204Q | P43354 | protein_coding | tolerated(0.36) | benign(0.206) | TCGA-05-4417-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NR4A2 | SNV | Missense_Mutation | c.976N>T | p.Val326Phe | p.V326F | P43354 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-35-5375-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
NR4A2 | SNV | Missense_Mutation | c.691N>T | p.Gly231Cys | p.G231C | P43354 | protein_coding | deleterious(0.05) | benign(0.003) | TCGA-44-7670-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | |
NR4A2 | SNV | Missense_Mutation | c.91A>T | p.Ser31Cys | p.S31C | P43354 | protein_coding | deleterious(0.01) | possibly_damaging(0.827) | TCGA-44-8117-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
NR4A2 | SNV | Missense_Mutation | c.1690N>T | p.Thr564Ser | p.T564S | P43354 | protein_coding | tolerated(0.62) | benign(0.021) | TCGA-44-A479-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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