![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: NOVA1 |
Gene summary for NOVA1 |
![]() |
Gene information | Species | Human | Gene symbol | NOVA1 | Gene ID | 4857 |
Gene name | NOVA alternative splicing regulator 1 | |
Gene Alias | Nova-1 | |
Cytomap | 14q12 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | P51513 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4857 | NOVA1 | GSM4909281 | Human | Breast | IDC | 1.02e-02 | -1.44e-01 | 0.21 |
4857 | NOVA1 | GSM4909282 | Human | Breast | IDC | 1.72e-05 | -1.53e-01 | -0.0288 |
4857 | NOVA1 | GSM4909285 | Human | Breast | IDC | 8.07e-06 | -1.53e-01 | 0.21 |
4857 | NOVA1 | GSM4909286 | Human | Breast | IDC | 8.07e-06 | -1.51e-01 | 0.1081 |
4857 | NOVA1 | GSM4909293 | Human | Breast | IDC | 4.18e-38 | 7.18e-01 | 0.1581 |
4857 | NOVA1 | GSM4909294 | Human | Breast | IDC | 1.08e-04 | -1.44e-01 | 0.2022 |
4857 | NOVA1 | GSM4909298 | Human | Breast | IDC | 1.54e-03 | -1.49e-01 | 0.1551 |
4857 | NOVA1 | GSM4909307 | Human | Breast | IDC | 1.53e-02 | 2.90e-01 | 0.1569 |
4857 | NOVA1 | GSM4909308 | Human | Breast | IDC | 1.63e-28 | 5.86e-01 | 0.158 |
4857 | NOVA1 | GSM4909311 | Human | Breast | IDC | 1.53e-05 | 4.29e-02 | 0.1534 |
4857 | NOVA1 | GSM4909319 | Human | Breast | IDC | 1.72e-05 | -1.53e-01 | 0.1563 |
4857 | NOVA1 | brca1 | Human | Breast | Precancer | 8.07e-06 | -1.40e-01 | -0.0338 |
4857 | NOVA1 | M5 | Human | Breast | IDC | 5.44e-15 | 1.08e+00 | 0.1598 |
4857 | NOVA1 | NCCBC14 | Human | Breast | DCIS | 3.83e-02 | -1.53e-01 | 0.2021 |
4857 | NOVA1 | NCCBC5 | Human | Breast | DCIS | 4.86e-02 | -1.53e-01 | 0.2046 |
4857 | NOVA1 | HTA12-15-2 | Human | Pancreas | PDAC | 4.45e-06 | 5.12e-01 | 0.2315 |
4857 | NOVA1 | HTA12-23-1 | Human | Pancreas | PDAC | 1.74e-14 | 1.02e+00 | 0.3405 |
4857 | NOVA1 | HTA12-25-1 | Human | Pancreas | PDAC | 1.33e-13 | 8.10e-01 | 0.313 |
4857 | NOVA1 | HTA12-26-1 | Human | Pancreas | PDAC | 1.22e-27 | 1.14e+00 | 0.3728 |
4857 | NOVA1 | HTA12-29-1 | Human | Pancreas | PDAC | 8.84e-67 | 1.15e+00 | 0.3722 |
Page: 1 2 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00083809 | Breast | Precancer | RNA splicing | 65/1080 | 434/18723 | 1.27e-12 | 2.53e-10 | 65 |
GO:00434849 | Breast | Precancer | regulation of RNA splicing | 34/1080 | 148/18723 | 2.66e-12 | 4.75e-10 | 34 |
GO:00003759 | Breast | Precancer | RNA splicing, via transesterification reactions | 52/1080 | 324/18723 | 1.74e-11 | 2.22e-09 | 52 |
GO:00003779 | Breast | Precancer | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 51/1080 | 320/18723 | 3.55e-11 | 4.04e-09 | 51 |
GO:00003989 | Breast | Precancer | mRNA splicing, via spliceosome | 51/1080 | 320/18723 | 3.55e-11 | 4.04e-09 | 51 |
GO:00480249 | Breast | Precancer | regulation of mRNA splicing, via spliceosome | 22/1080 | 101/18723 | 5.29e-08 | 3.18e-06 | 22 |
GO:19033118 | Breast | Precancer | regulation of mRNA metabolic process | 38/1080 | 288/18723 | 1.63e-06 | 5.97e-05 | 38 |
GO:00506848 | Breast | Precancer | regulation of mRNA processing | 23/1080 | 137/18723 | 3.49e-06 | 1.13e-04 | 23 |
GO:00003808 | Breast | Precancer | alternative mRNA splicing, via spliceosome | 15/1080 | 77/18723 | 2.86e-05 | 6.37e-04 | 15 |
GO:00003818 | Breast | Precancer | regulation of alternative mRNA splicing, via spliceosome | 13/1080 | 60/18723 | 2.98e-05 | 6.58e-04 | 13 |
GO:000838014 | Breast | IDC | RNA splicing | 73/1434 | 434/18723 | 1.27e-10 | 1.57e-08 | 73 |
GO:004348414 | Breast | IDC | regulation of RNA splicing | 36/1434 | 148/18723 | 3.32e-10 | 3.77e-08 | 36 |
GO:000037514 | Breast | IDC | RNA splicing, via transesterification reactions | 58/1434 | 324/18723 | 9.44e-10 | 9.58e-08 | 58 |
GO:000037714 | Breast | IDC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 57/1434 | 320/18723 | 1.60e-09 | 1.49e-07 | 57 |
GO:000039814 | Breast | IDC | mRNA splicing, via spliceosome | 57/1434 | 320/18723 | 1.60e-09 | 1.49e-07 | 57 |
GO:004802414 | Breast | IDC | regulation of mRNA splicing, via spliceosome | 23/1434 | 101/18723 | 1.74e-06 | 7.28e-05 | 23 |
GO:005068413 | Breast | IDC | regulation of mRNA processing | 24/1434 | 137/18723 | 1.09e-04 | 2.04e-03 | 24 |
GO:190331113 | Breast | IDC | regulation of mRNA metabolic process | 40/1434 | 288/18723 | 1.79e-04 | 3.01e-03 | 40 |
GO:000038113 | Breast | IDC | regulation of alternative mRNA splicing, via spliceosome | 13/1434 | 60/18723 | 5.09e-04 | 6.65e-03 | 13 |
GO:000038013 | Breast | IDC | alternative mRNA splicing, via spliceosome | 15/1434 | 77/18723 | 6.51e-04 | 8.04e-03 | 15 |
Page: 1 2 3 4 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NOVA1 | SNV | Missense_Mutation | c.1121G>C | p.Ser374Thr | p.S374T | P51513 | protein_coding | tolerated(0.49) | benign(0.1) | TCGA-69-7979-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NOVA1 | SNV | Missense_Mutation | c.304A>T | p.Ile102Phe | p.I102F | P51513 | protein_coding | deleterious(0) | probably_damaging(0.923) | TCGA-78-7150-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD | |
NOVA1 | SNV | Missense_Mutation | c.1519G>T | p.Gly507Cys | p.G507C | P51513 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.999) | TCGA-78-7155-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD | |
NOVA1 | SNV | Missense_Mutation | novel | c.280G>T | p.Gly94Cys | p.G94C | P51513 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-78-8662-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
NOVA1 | SNV | Missense_Mutation | rs200148996 | c.778N>T | p.Gly260Cys | p.G260C | P51513 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-86-6851-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NOVA1 | SNV | Missense_Mutation | c.873T>A | p.His291Gln | p.H291Q | P51513 | protein_coding | tolerated(0.33) | benign(0) | TCGA-86-8358-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
NOVA1 | SNV | Missense_Mutation | c.577A>T | p.Thr193Ser | p.T193S | P51513 | protein_coding | deleterious(0.04) | probably_damaging(0.953) | TCGA-91-6829-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NOVA1 | SNV | Missense_Mutation | novel | c.550N>T | p.Gly184Cys | p.G184C | P51513 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-95-7039-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
NOVA1 | SNV | Missense_Mutation | c.281N>T | p.Gly94Val | p.G94V | P51513 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-99-AA5R-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NOVA1 | SNV | Missense_Mutation | c.869N>T | p.Gly290Val | p.G290V | P51513 | protein_coding | deleterious(0.04) | probably_damaging(0.998) | TCGA-22-4613-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |