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Gene: NOD1 |
Gene summary for NOD1 |
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Gene information | Species | Human | Gene symbol | NOD1 | Gene ID | 10392 |
Gene name | nucleotide binding oligomerization domain containing 1 | |
Gene Alias | CARD4 | |
Cytomap | 7p14.3 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | A0A024RA73 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10392 | NOD1 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 5.65e-05 | 4.15e-01 | -0.2116 |
10392 | NOD1 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 5.14e-03 | 3.87e-01 | -0.2119 |
10392 | NOD1 | RNA-P3T-P3T-1 | Human | Lung | IAC | 4.51e-05 | 5.81e-01 | 0.1829 |
10392 | NOD1 | RNA-P3T-P3T-2 | Human | Lung | IAC | 1.15e-04 | 5.78e-01 | 0.1835 |
10392 | NOD1 | RNA-P3T-P3T-4 | Human | Lung | IAC | 4.99e-05 | 5.76e-01 | 0.1859 |
10392 | NOD1 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 1.02e-09 | 4.45e-01 | -0.0166 |
10392 | NOD1 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 1.80e-15 | 4.82e-01 | -0.0132 |
10392 | NOD1 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 1.45e-14 | 4.60e-01 | -0.013 |
10392 | NOD1 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 5.47e-04 | 2.87e-01 | -0.0121 |
10392 | NOD1 | male-WTA | Human | Thyroid | PTC | 8.91e-35 | 3.53e-01 | 0.1037 |
10392 | NOD1 | PTC01 | Human | Thyroid | PTC | 7.53e-19 | 3.82e-01 | 0.1899 |
10392 | NOD1 | PTC04 | Human | Thyroid | PTC | 8.98e-16 | 4.07e-01 | 0.1927 |
10392 | NOD1 | PTC05 | Human | Thyroid | PTC | 2.84e-31 | 1.11e+00 | 0.2065 |
10392 | NOD1 | PTC06 | Human | Thyroid | PTC | 1.69e-49 | 9.46e-01 | 0.2057 |
10392 | NOD1 | PTC07 | Human | Thyroid | PTC | 1.06e-43 | 7.69e-01 | 0.2044 |
10392 | NOD1 | ATC12 | Human | Thyroid | ATC | 7.85e-04 | 2.27e-02 | 0.34 |
10392 | NOD1 | ATC13 | Human | Thyroid | ATC | 1.34e-08 | 1.72e-01 | 0.34 |
10392 | NOD1 | ATC4 | Human | Thyroid | ATC | 1.89e-02 | 4.22e-02 | 0.34 |
10392 | NOD1 | ATC5 | Human | Thyroid | ATC | 9.31e-15 | 1.91e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00098968 | Lung | IAC | positive regulation of catabolic process | 114/2061 | 492/18723 | 4.93e-15 | 1.25e-11 | 114 |
GO:00313318 | Lung | IAC | positive regulation of cellular catabolic process | 98/2061 | 427/18723 | 7.79e-13 | 9.25e-10 | 98 |
GO:00458628 | Lung | IAC | positive regulation of proteolysis | 80/2061 | 372/18723 | 2.62e-09 | 4.21e-07 | 80 |
GO:00310987 | Lung | IAC | stress-activated protein kinase signaling cascade | 57/2061 | 247/18723 | 3.95e-08 | 4.57e-06 | 57 |
GO:00514037 | Lung | IAC | stress-activated MAPK cascade | 54/2061 | 239/18723 | 1.86e-07 | 1.56e-05 | 54 |
GO:00072544 | Lung | IAC | JNK cascade | 42/2061 | 167/18723 | 1.99e-07 | 1.62e-05 | 42 |
GO:00105066 | Lung | IAC | regulation of autophagy | 65/2061 | 317/18723 | 4.97e-07 | 3.14e-05 | 65 |
GO:00703026 | Lung | IAC | regulation of stress-activated protein kinase signaling cascade | 45/2061 | 195/18723 | 1.03e-06 | 5.65e-05 | 45 |
GO:00463284 | Lung | IAC | regulation of JNK cascade | 34/2061 | 133/18723 | 1.88e-06 | 8.87e-05 | 34 |
GO:19016537 | Lung | IAC | cellular response to peptide | 69/2061 | 359/18723 | 2.62e-06 | 1.14e-04 | 69 |
GO:00328726 | Lung | IAC | regulation of stress-activated MAPK cascade | 43/2061 | 192/18723 | 4.06e-06 | 1.66e-04 | 43 |
GO:00072495 | Lung | IAC | I-kappaB kinase/NF-kappaB signaling | 56/2061 | 281/18723 | 7.39e-06 | 2.62e-04 | 56 |
GO:00431226 | Lung | IAC | regulation of I-kappaB kinase/NF-kappaB signaling | 51/2061 | 249/18723 | 8.41e-06 | 2.87e-04 | 51 |
GO:20001168 | Lung | IAC | regulation of cysteine-type endopeptidase activity | 48/2061 | 235/18723 | 1.65e-05 | 4.73e-04 | 48 |
GO:00525478 | Lung | IAC | regulation of peptidase activity | 80/2061 | 461/18723 | 2.39e-05 | 6.50e-04 | 80 |
GO:00432818 | Lung | IAC | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 43/2061 | 209/18723 | 3.71e-05 | 9.14e-04 | 43 |
GO:00525488 | Lung | IAC | regulation of endopeptidase activity | 75/2061 | 432/18723 | 4.18e-05 | 1.01e-03 | 75 |
GO:00109528 | Lung | IAC | positive regulation of peptidase activity | 41/2061 | 197/18723 | 4.22e-05 | 1.02e-03 | 41 |
GO:00510903 | Lung | IAC | regulation of DNA-binding transcription factor activity | 76/2061 | 440/18723 | 4.44e-05 | 1.05e-03 | 76 |
GO:00510914 | Lung | IAC | positive regulation of DNA-binding transcription factor activity | 50/2061 | 260/18723 | 5.87e-05 | 1.29e-03 | 50 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513116 | Lung | IAC | Shigellosis | 58/1053 | 247/8465 | 8.21e-07 | 3.81e-05 | 2.53e-05 | 58 |
hsa0513216 | Lung | IAC | Salmonella infection | 52/1053 | 249/8465 | 9.46e-05 | 1.28e-03 | 8.50e-04 | 52 |
hsa051205 | Lung | IAC | Epithelial cell signaling in Helicobacter pylori infection | 20/1053 | 70/8465 | 2.31e-04 | 2.54e-03 | 1.68e-03 | 20 |
hsa046212 | Lung | IAC | NOD-like receptor signaling pathway | 38/1053 | 186/8465 | 1.23e-03 | 8.24e-03 | 5.47e-03 | 38 |
hsa0513117 | Lung | IAC | Shigellosis | 58/1053 | 247/8465 | 8.21e-07 | 3.81e-05 | 2.53e-05 | 58 |
hsa0513217 | Lung | IAC | Salmonella infection | 52/1053 | 249/8465 | 9.46e-05 | 1.28e-03 | 8.50e-04 | 52 |
hsa0512012 | Lung | IAC | Epithelial cell signaling in Helicobacter pylori infection | 20/1053 | 70/8465 | 2.31e-04 | 2.54e-03 | 1.68e-03 | 20 |
hsa0462111 | Lung | IAC | NOD-like receptor signaling pathway | 38/1053 | 186/8465 | 1.23e-03 | 8.24e-03 | 5.47e-03 | 38 |
hsa0513123 | Lung | AIS | Shigellosis | 53/961 | 247/8465 | 2.70e-06 | 9.71e-05 | 6.21e-05 | 53 |
hsa0513223 | Lung | AIS | Salmonella infection | 50/961 | 249/8465 | 3.47e-05 | 5.62e-04 | 3.59e-04 | 50 |
hsa0512021 | Lung | AIS | Epithelial cell signaling in Helicobacter pylori infection | 15/961 | 70/8465 | 1.07e-02 | 4.45e-02 | 2.85e-02 | 15 |
hsa0513133 | Lung | AIS | Shigellosis | 53/961 | 247/8465 | 2.70e-06 | 9.71e-05 | 6.21e-05 | 53 |
hsa0513233 | Lung | AIS | Salmonella infection | 50/961 | 249/8465 | 3.47e-05 | 5.62e-04 | 3.59e-04 | 50 |
hsa0512031 | Lung | AIS | Epithelial cell signaling in Helicobacter pylori infection | 15/961 | 70/8465 | 1.07e-02 | 4.45e-02 | 2.85e-02 | 15 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NOD1 | SNV | Missense_Mutation | rs759079848 | c.1816C>T | p.His606Tyr | p.H606Y | Q9Y239 | protein_coding | deleterious(0) | benign(0) | TCGA-49-AARN-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NOD1 | SNV | Missense_Mutation | rs776927719 | c.680G>T | p.Gly227Val | p.G227V | Q9Y239 | protein_coding | tolerated(0.17) | benign(0.322) | TCGA-50-6593-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
NOD1 | SNV | Missense_Mutation | c.1103G>T | p.Arg368Leu | p.R368L | Q9Y239 | protein_coding | tolerated(0.16) | benign(0.005) | TCGA-91-6836-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NOD1 | SNV | Missense_Mutation | rs755565671 | c.1714G>T | p.Gly572Cys | p.G572C | Q9Y239 | protein_coding | deleterious(0.03) | benign(0.124) | TCGA-95-A4VK-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD |
NOD1 | SNV | Missense_Mutation | rs139576372 | c.668G>A | p.Arg223Gln | p.R223Q | Q9Y239 | protein_coding | tolerated(0.54) | benign(0.001) | TCGA-L9-A5IP-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
NOD1 | SNV | Missense_Mutation | rs780905084 | c.714N>A | p.Met238Ile | p.M238I | Q9Y239 | protein_coding | tolerated(0.18) | benign(0.117) | TCGA-NJ-A4YP-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NOD1 | SNV | Missense_Mutation | rs6947097 | c.164N>T | p.Ala55Val | p.A55V | Q9Y239 | protein_coding | tolerated(1) | benign(0.061) | TCGA-22-4599-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NOD1 | SNV | Missense_Mutation | c.2741N>A | p.Ala914Asp | p.A914D | Q9Y239 | protein_coding | tolerated(0.35) | benign(0) | TCGA-33-4583-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NOD1 | SNV | Missense_Mutation | novel | c.2108C>A | p.Pro703His | p.P703H | Q9Y239 | protein_coding | tolerated(0.25) | benign(0) | TCGA-37-3789-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NOD1 | SNV | Missense_Mutation | novel | c.2101N>T | p.His701Tyr | p.H701Y | Q9Y239 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-56-8624-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10392 | NOD1 | CLINICALLY ACTIONABLE, DRUGGABLE GENOME | agonist | 178101718 | ||
10392 | NOD1 | CLINICALLY ACTIONABLE, DRUGGABLE GENOME | GNF-PF-3971 | CHEMBL599890 | ||
10392 | NOD1 | CLINICALLY ACTIONABLE, DRUGGABLE GENOME | TRACHEAL CYTOTOXIN | TRACHEAL CYTOTOXIN | 21341753 | |
10392 | NOD1 | CLINICALLY ACTIONABLE, DRUGGABLE GENOME | inhibitor | 310264668 |
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