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Gene: NCAPH |
Gene summary for NCAPH |
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Gene information | Species | Human | Gene symbol | NCAPH | Gene ID | 23397 |
Gene name | non-SMC condensin I complex subunit H | |
Gene Alias | BRRN1 | |
Cytomap | 2q11.2 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | Q15003 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23397 | NCAPH | P2T-E | Human | Esophagus | ESCC | 9.53e-09 | 2.72e-01 | 0.1177 |
23397 | NCAPH | P4T-E | Human | Esophagus | ESCC | 1.45e-04 | 2.47e-01 | 0.1323 |
23397 | NCAPH | P5T-E | Human | Esophagus | ESCC | 1.22e-12 | 2.75e-01 | 0.1327 |
23397 | NCAPH | P10T-E | Human | Esophagus | ESCC | 2.02e-06 | 2.23e-01 | 0.116 |
23397 | NCAPH | P21T-E | Human | Esophagus | ESCC | 1.73e-03 | 1.68e-01 | 0.1617 |
23397 | NCAPH | P22T-E | Human | Esophagus | ESCC | 3.75e-03 | 1.16e-01 | 0.1236 |
23397 | NCAPH | P24T-E | Human | Esophagus | ESCC | 9.20e-06 | 2.78e-01 | 0.1287 |
23397 | NCAPH | P28T-E | Human | Esophagus | ESCC | 3.44e-09 | 1.79e-01 | 0.1149 |
23397 | NCAPH | P31T-E | Human | Esophagus | ESCC | 4.31e-06 | 1.64e-01 | 0.1251 |
23397 | NCAPH | P32T-E | Human | Esophagus | ESCC | 3.60e-13 | 3.07e-01 | 0.1666 |
23397 | NCAPH | P37T-E | Human | Esophagus | ESCC | 4.15e-03 | 1.87e-01 | 0.1371 |
23397 | NCAPH | P38T-E | Human | Esophagus | ESCC | 3.02e-06 | 5.14e-01 | 0.127 |
23397 | NCAPH | P48T-E | Human | Esophagus | ESCC | 7.90e-03 | 1.11e-01 | 0.0959 |
23397 | NCAPH | P52T-E | Human | Esophagus | ESCC | 4.30e-10 | 2.97e-01 | 0.1555 |
23397 | NCAPH | P74T-E | Human | Esophagus | ESCC | 9.14e-05 | 3.59e-01 | 0.1479 |
23397 | NCAPH | P75T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.70e-01 | 0.1125 |
23397 | NCAPH | P76T-E | Human | Esophagus | ESCC | 2.06e-03 | 2.80e-01 | 0.1207 |
23397 | NCAPH | P79T-E | Human | Esophagus | ESCC | 4.31e-06 | 2.11e-01 | 0.1154 |
23397 | NCAPH | P83T-E | Human | Esophagus | ESCC | 2.33e-12 | 6.10e-01 | 0.1738 |
23397 | NCAPH | P89T-E | Human | Esophagus | ESCC | 3.59e-04 | 4.30e-01 | 0.1752 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:014001414 | Esophagus | ESCC | mitotic nuclear division | 218/8552 | 287/18723 | 6.17e-26 | 1.78e-23 | 218 |
GO:000007011 | Esophagus | ESCC | mitotic sister chromatid segregation | 138/8552 | 168/18723 | 1.37e-22 | 2.63e-20 | 138 |
GO:00008194 | Esophagus | ESCC | sister chromatid segregation | 157/8552 | 202/18723 | 8.41e-21 | 1.33e-18 | 157 |
GO:000705911 | Esophagus | ESCC | chromosome segregation | 238/8552 | 346/18723 | 1.72e-18 | 1.82e-16 | 238 |
GO:00482853 | Esophagus | ESCC | organelle fission | 301/8552 | 488/18723 | 4.64e-13 | 2.12e-11 | 301 |
GO:00988133 | Esophagus | ESCC | nuclear chromosome segregation | 187/8552 | 281/18723 | 1.00e-12 | 4.36e-11 | 187 |
GO:00002802 | Esophagus | ESCC | nuclear division | 270/8552 | 439/18723 | 1.17e-11 | 4.24e-10 | 270 |
GO:00513062 | Esophagus | ESCC | mitotic sister chromatid separation | 52/8552 | 67/18723 | 9.14e-08 | 1.52e-06 | 52 |
GO:00513042 | Esophagus | ESCC | chromosome separation | 64/8552 | 96/18723 | 2.61e-05 | 2.20e-04 | 64 |
GO:00070761 | Esophagus | ESCC | mitotic chromosome condensation | 15/8552 | 17/18723 | 3.48e-04 | 2.03e-03 | 15 |
GO:004211018 | Esophagus | ESCC | T cell activation | 256/8552 | 487/18723 | 1.18e-03 | 5.87e-03 | 256 |
GO:19031317 | Esophagus | ESCC | mononuclear cell differentiation | 226/8552 | 426/18723 | 1.20e-03 | 5.88e-03 | 226 |
GO:00302176 | Esophagus | ESCC | T cell differentiation | 137/8552 | 257/18723 | 8.09e-03 | 2.87e-02 | 137 |
GO:00300984 | Esophagus | ESCC | lymphocyte differentiation | 192/8552 | 374/18723 | 1.52e-02 | 4.93e-02 | 192 |
GO:014001411 | Liver | HCC | mitotic nuclear division | 174/7958 | 287/18723 | 3.74e-10 | 1.23e-08 | 174 |
GO:0000070 | Liver | HCC | mitotic sister chromatid segregation | 110/7958 | 168/18723 | 1.42e-09 | 4.25e-08 | 110 |
GO:00008191 | Liver | HCC | sister chromatid segregation | 128/7958 | 202/18723 | 1.59e-09 | 4.73e-08 | 128 |
GO:0007059 | Liver | HCC | chromosome segregation | 197/7958 | 346/18723 | 3.57e-08 | 7.87e-07 | 197 |
GO:0098813 | Liver | HCC | nuclear chromosome segregation | 157/7958 | 281/18723 | 3.82e-06 | 4.95e-05 | 157 |
GO:0048285 | Liver | HCC | organelle fission | 254/7958 | 488/18723 | 1.07e-05 | 1.23e-04 | 254 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NCAPH | SNV | Missense_Mutation | c.439G>C | p.Glu147Gln | p.E147Q | Q15003 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CR-7402-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD | |
NCAPH | SNV | Missense_Mutation | c.1051N>T | p.Asp351Tyr | p.D351Y | Q15003 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-J4-A67N-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | PD | |
NCAPH | SNV | Missense_Mutation | c.1140N>A | p.Asp380Glu | p.D380E | Q15003 | protein_coding | tolerated(0.36) | benign(0.031) | TCGA-CG-4476-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
NCAPH | SNV | Missense_Mutation | rs759878969 | c.248N>A | p.Arg83His | p.R83H | Q15003 | protein_coding | tolerated(0.62) | benign(0) | TCGA-CG-5726-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NCAPH | SNV | Missense_Mutation | novel | c.928G>A | p.Ala310Thr | p.A310T | Q15003 | protein_coding | tolerated(0.27) | benign(0.011) | TCGA-HF-A5NB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | SD |
NCAPH | SNV | Missense_Mutation | novel | c.121N>C | p.Lys41Gln | p.K41Q | Q15003 | protein_coding | tolerated(0.14) | benign(0.054) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
NCAPH | SNV | Missense_Mutation | novel | c.1253N>A | p.Cys418Tyr | p.C418Y | Q15003 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
NCAPH | SNV | Missense_Mutation | novel | c.1816C>T | p.Pro606Ser | p.P606S | Q15003 | protein_coding | tolerated(0.52) | benign(0.019) | TCGA-VQ-A8PO-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
NCAPH | SNV | Missense_Mutation | novel | c.1795N>C | p.Ala599Pro | p.A599P | Q15003 | protein_coding | tolerated(0.19) | benign(0.003) | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
NCAPH | deletion | Frame_Shift_Del | c.1228delN | p.Asp411MetfsTer13 | p.D411Mfs*13 | Q15003 | protein_coding | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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