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Gene: MTSS1 |
Gene summary for MTSS1 |
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Gene information | Species | Human | Gene symbol | MTSS1 | Gene ID | 9788 |
Gene name | MTSS I-BAR domain containing 1 | |
Gene Alias | MIM | |
Cytomap | 8q24.13 | |
Gene Type | protein-coding | GO ID | GO:0001655 | UniProtAcc | O43312 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9788 | MTSS1 | CA_HPV_1 | Human | Cervix | CC | 9.58e-07 | -1.98e-01 | 0.0264 |
9788 | MTSS1 | CCI_1 | Human | Cervix | CC | 6.66e-11 | 1.37e+00 | 0.528 |
9788 | MTSS1 | CCI_2 | Human | Cervix | CC | 6.06e-07 | 1.11e+00 | 0.5249 |
9788 | MTSS1 | CCI_3 | Human | Cervix | CC | 6.23e-11 | 1.32e+00 | 0.516 |
9788 | MTSS1 | Tumor | Human | Cervix | CC | 1.83e-04 | 3.15e-01 | 0.1241 |
9788 | MTSS1 | sample3 | Human | Cervix | CC | 4.56e-12 | 4.30e-01 | 0.1387 |
9788 | MTSS1 | H2 | Human | Cervix | HSIL_HPV | 6.48e-04 | -1.83e-01 | 0.0632 |
9788 | MTSS1 | T3 | Human | Cervix | CC | 1.06e-08 | 4.04e-01 | 0.1389 |
9788 | MTSS1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.48e-06 | -4.10e-01 | 0.0155 |
9788 | MTSS1 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.18e-05 | -4.38e-01 | 0.096 |
9788 | MTSS1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 6.66e-12 | -5.54e-01 | 0.294 |
9788 | MTSS1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.22e-06 | -5.88e-01 | 0.281 |
9788 | MTSS1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.45e-03 | -4.32e-01 | 0.3859 |
9788 | MTSS1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.90e-12 | -8.22e-01 | 0.2585 |
9788 | MTSS1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 8.41e-15 | -6.20e-01 | 0.3005 |
9788 | MTSS1 | F007 | Human | Colorectum | FAP | 3.79e-02 | -2.37e-01 | 0.1176 |
9788 | MTSS1 | A002-C-010 | Human | Colorectum | FAP | 1.82e-02 | -2.03e-01 | 0.242 |
9788 | MTSS1 | A001-C-207 | Human | Colorectum | FAP | 2.05e-04 | -2.78e-01 | 0.1278 |
9788 | MTSS1 | A015-C-203 | Human | Colorectum | FAP | 6.60e-27 | -4.79e-01 | -0.1294 |
9788 | MTSS1 | A015-C-204 | Human | Colorectum | FAP | 3.36e-08 | -3.59e-01 | -0.0228 |
Page: 1 2 3 4 5 6 7 8 9 10 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000701510 | Cervix | CC | actin filament organization | 109/2311 | 442/18723 | 4.92e-13 | 2.45e-10 | 109 |
GO:003297010 | Cervix | CC | regulation of actin filament-based process | 96/2311 | 397/18723 | 4.00e-11 | 8.54e-09 | 96 |
GO:190290310 | Cervix | CC | regulation of supramolecular fiber organization | 92/2311 | 383/18723 | 1.49e-10 | 2.48e-08 | 92 |
GO:003295610 | Cervix | CC | regulation of actin cytoskeleton organization | 86/2311 | 358/18723 | 5.90e-10 | 7.51e-08 | 86 |
GO:00506737 | Cervix | CC | epithelial cell proliferation | 98/2311 | 437/18723 | 2.01e-09 | 2.15e-07 | 98 |
GO:00452169 | Cervix | CC | cell-cell junction organization | 53/2311 | 200/18723 | 3.83e-08 | 2.53e-06 | 53 |
GO:011005310 | Cervix | CC | regulation of actin filament organization | 67/2311 | 278/18723 | 4.01e-08 | 2.54e-06 | 67 |
GO:00506787 | Cervix | CC | regulation of epithelial cell proliferation | 83/2311 | 381/18723 | 1.31e-07 | 6.42e-06 | 83 |
GO:006157210 | Cervix | CC | actin filament bundle organization | 44/2311 | 161/18723 | 2.08e-07 | 9.34e-06 | 44 |
GO:005101710 | Cervix | CC | actin filament bundle assembly | 43/2311 | 157/18723 | 2.66e-07 | 1.12e-05 | 43 |
GO:190290510 | Cervix | CC | positive regulation of supramolecular fiber organization | 50/2311 | 209/18723 | 2.55e-06 | 7.54e-05 | 50 |
GO:005149510 | Cervix | CC | positive regulation of cytoskeleton organization | 50/2311 | 226/18723 | 2.53e-05 | 4.29e-04 | 50 |
GO:003223110 | Cervix | CC | regulation of actin filament bundle assembly | 28/2311 | 105/18723 | 5.19e-05 | 7.79e-04 | 28 |
GO:00322339 | Cervix | CC | positive regulation of actin filament bundle assembly | 18/2311 | 63/18723 | 4.39e-04 | 4.39e-03 | 18 |
GO:00605626 | Cervix | CC | epithelial tube morphogenesis | 57/2311 | 325/18723 | 3.79e-03 | 2.41e-02 | 57 |
GO:00343326 | Cervix | CC | adherens junction organization | 13/2311 | 49/18723 | 5.34e-03 | 3.10e-02 | 13 |
GO:00070092 | Cervix | CC | plasma membrane organization | 28/2311 | 142/18723 | 7.85e-03 | 4.14e-02 | 28 |
GO:00343316 | Cervix | CC | cell junction maintenance | 10/2311 | 35/18723 | 7.99e-03 | 4.18e-02 | 10 |
GO:00344051 | Cervix | CC | response to fluid shear stress | 10/2311 | 35/18723 | 7.99e-03 | 4.18e-02 | 10 |
GO:00714983 | Cervix | CC | cellular response to fluid shear stress | 7/2311 | 21/18723 | 1.04e-02 | 4.97e-02 | 7 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MTSS1 | insertion | Nonsense_Mutation | novel | c.1685_1686insATA | p.Ser561_Tyr562insTer | p.S561_Y562ins* | O43312 | protein_coding | TCGA-RC-A7SB-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
MTSS1 | SNV | Missense_Mutation | novel | c.212N>T | p.Gly71Val | p.G71V | O43312 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-55-7907-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MTSS1 | SNV | Missense_Mutation | c.208N>T | p.Gly70Cys | p.G70C | O43312 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-67-6217-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Targeted Molecular therapy | tarceva | SD | |
MTSS1 | SNV | Missense_Mutation | novel | c.1871N>A | p.Thr624Asn | p.T624N | O43312 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-MN-A4N4-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MTSS1 | SNV | Missense_Mutation | c.620N>A | p.Arg207Gln | p.R207Q | O43312 | protein_coding | tolerated(1) | probably_damaging(1) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
MTSS1 | SNV | Missense_Mutation | c.1918G>A | p.Gly640Arg | p.G640R | O43312 | protein_coding | deleterious(0.03) | probably_damaging(0.995) | TCGA-21-5787-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
MTSS1 | SNV | Missense_Mutation | rs140769162 | c.1243N>A | p.Asp415Asn | p.D415N | O43312 | protein_coding | deleterious(0.05) | probably_damaging(1) | TCGA-34-8454-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
MTSS1 | SNV | Missense_Mutation | novel | c.877G>T | p.Gly293Cys | p.G293C | O43312 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-39-5039-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MTSS1 | SNV | Missense_Mutation | novel | c.931N>A | p.Ala311Thr | p.A311T | O43312 | protein_coding | deleterious(0.04) | benign(0.003) | TCGA-46-3766-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MTSS1 | SNV | Missense_Mutation | novel | c.1093N>A | p.Val365Met | p.V365M | O43312 | protein_coding | tolerated(0.26) | benign(0.015) | TCGA-51-6867-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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