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Gene: MTA1 |
Gene summary for MTA1 |
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Gene information | Species | Human | Gene symbol | MTA1 | Gene ID | 9112 |
Gene name | metastasis associated 1 | |
Gene Alias | MTA1 | |
Cytomap | 14q32.33 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q13330 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9112 | MTA1 | LZE2T | Human | Esophagus | ESCC | 9.74e-05 | 5.95e-01 | 0.082 |
9112 | MTA1 | LZE4T | Human | Esophagus | ESCC | 1.45e-03 | -3.60e-04 | 0.0811 |
9112 | MTA1 | LZE5T | Human | Esophagus | ESCC | 2.95e-02 | 3.24e-01 | 0.0514 |
9112 | MTA1 | LZE22T | Human | Esophagus | ESCC | 3.92e-06 | 2.99e-01 | 0.068 |
9112 | MTA1 | LZE24T | Human | Esophagus | ESCC | 1.62e-15 | 1.17e-01 | 0.0596 |
9112 | MTA1 | P1T-E | Human | Esophagus | ESCC | 7.85e-13 | 3.68e-01 | 0.0875 |
9112 | MTA1 | P2T-E | Human | Esophagus | ESCC | 6.01e-17 | 2.62e-01 | 0.1177 |
9112 | MTA1 | P4T-E | Human | Esophagus | ESCC | 4.10e-29 | 7.81e-01 | 0.1323 |
9112 | MTA1 | P5T-E | Human | Esophagus | ESCC | 2.22e-21 | 3.53e-01 | 0.1327 |
9112 | MTA1 | P8T-E | Human | Esophagus | ESCC | 4.30e-43 | 1.15e+00 | 0.0889 |
9112 | MTA1 | P9T-E | Human | Esophagus | ESCC | 3.30e-07 | 9.21e-02 | 0.1131 |
9112 | MTA1 | P10T-E | Human | Esophagus | ESCC | 4.45e-27 | 5.67e-01 | 0.116 |
9112 | MTA1 | P11T-E | Human | Esophagus | ESCC | 2.25e-06 | 1.80e-01 | 0.1426 |
9112 | MTA1 | P12T-E | Human | Esophagus | ESCC | 5.71e-37 | 6.95e-01 | 0.1122 |
9112 | MTA1 | P15T-E | Human | Esophagus | ESCC | 1.29e-53 | 1.15e+00 | 0.1149 |
9112 | MTA1 | P16T-E | Human | Esophagus | ESCC | 5.83e-37 | 6.92e-01 | 0.1153 |
9112 | MTA1 | P17T-E | Human | Esophagus | ESCC | 2.61e-06 | 3.00e-01 | 0.1278 |
9112 | MTA1 | P19T-E | Human | Esophagus | ESCC | 2.84e-04 | 3.76e-01 | 0.1662 |
9112 | MTA1 | P20T-E | Human | Esophagus | ESCC | 5.55e-11 | 2.32e-01 | 0.1124 |
9112 | MTA1 | P21T-E | Human | Esophagus | ESCC | 1.10e-17 | 3.65e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00353049 | Breast | Precancer | regulation of protein dephosphorylation | 14/1080 | 90/18723 | 6.16e-04 | 7.72e-03 | 14 |
GO:003530414 | Breast | IDC | regulation of protein dephosphorylation | 18/1434 | 90/18723 | 1.39e-04 | 2.48e-03 | 18 |
GO:003530423 | Breast | DCIS | regulation of protein dephosphorylation | 18/1390 | 90/18723 | 9.33e-05 | 1.71e-03 | 18 |
GO:00353039 | Breast | DCIS | regulation of dephosphorylation | 18/1390 | 128/18723 | 6.44e-03 | 4.58e-02 | 18 |
GO:00508481 | Breast | DCIS | regulation of calcium-mediated signaling | 12/1390 | 73/18723 | 7.17e-03 | 4.85e-02 | 12 |
GO:0016311 | Colorectum | AD | dephosphorylation | 123/3918 | 417/18723 | 1.84e-05 | 3.82e-04 | 123 |
GO:0006470 | Colorectum | AD | protein dephosphorylation | 88/3918 | 281/18723 | 2.56e-05 | 4.89e-04 | 88 |
GO:0035303 | Colorectum | AD | regulation of dephosphorylation | 46/3918 | 128/18723 | 6.20e-05 | 1.04e-03 | 46 |
GO:0035304 | Colorectum | AD | regulation of protein dephosphorylation | 33/3918 | 90/18723 | 4.23e-04 | 4.77e-03 | 33 |
GO:0035306 | Colorectum | AD | positive regulation of dephosphorylation | 22/3918 | 59/18723 | 2.86e-03 | 2.14e-02 | 22 |
GO:00353032 | Colorectum | MSS | regulation of dephosphorylation | 41/3467 | 128/18723 | 1.64e-04 | 2.33e-03 | 41 |
GO:00353042 | Colorectum | MSS | regulation of protein dephosphorylation | 30/3467 | 90/18723 | 5.58e-04 | 6.19e-03 | 30 |
GO:00064702 | Colorectum | MSS | protein dephosphorylation | 73/3467 | 281/18723 | 1.15e-03 | 1.12e-02 | 73 |
GO:00163112 | Colorectum | MSS | dephosphorylation | 101/3467 | 417/18723 | 1.98e-03 | 1.70e-02 | 101 |
GO:00163113 | Colorectum | FAP | dephosphorylation | 95/2622 | 417/18723 | 7.07e-07 | 3.32e-05 | 95 |
GO:00064704 | Colorectum | FAP | protein dephosphorylation | 69/2622 | 281/18723 | 1.47e-06 | 6.39e-05 | 69 |
GO:00353034 | Colorectum | FAP | regulation of dephosphorylation | 36/2622 | 128/18723 | 2.22e-05 | 5.28e-04 | 36 |
GO:00353044 | Colorectum | FAP | regulation of protein dephosphorylation | 24/2622 | 90/18723 | 1.12e-03 | 1.08e-02 | 24 |
GO:0048016 | Colorectum | FAP | inositol phosphate-mediated signaling | 16/2622 | 55/18723 | 2.78e-03 | 2.15e-02 | 16 |
GO:00353061 | Colorectum | FAP | positive regulation of dephosphorylation | 16/2622 | 59/18723 | 5.95e-03 | 3.75e-02 | 16 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MTA1 | SNV | Missense_Mutation | c.1447N>T | p.Arg483Trp | p.R483W | Q13330 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-HU-8608-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | doxifluridine | PD | |
MTA1 | SNV | Missense_Mutation | c.1464G>T | p.Glu488Asp | p.E488D | Q13330 | protein_coding | tolerated(1) | benign(0) | TCGA-IP-7968-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
MTA1 | SNV | Missense_Mutation | rs782798640 | c.2084N>T | p.Ala695Val | p.A695V | Q13330 | protein_coding | tolerated(0.4) | benign(0.001) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
MTA1 | SNV | Missense_Mutation | novel | c.458A>G | p.Tyr153Cys | p.Y153C | Q13330 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-VQ-A8PP-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
MTA1 | SNV | Missense_Mutation | c.2044C>T | p.Arg682Cys | p.R682C | Q13330 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD | |
MTA1 | SNV | Missense_Mutation | novel | c.869N>T | p.Ala290Val | p.A290V | Q13330 | protein_coding | deleterious(0) | benign(0.313) | TCGA-VQ-A924-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MTA1 | deletion | Frame_Shift_Del | novel | c.1638delN | p.Lys549SerfsTer5 | p.K549Sfs*5 | Q13330 | protein_coding | TCGA-BR-8382-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
MTA1 | insertion | Frame_Shift_Ins | novel | c.1906_1907insG | p.Ser639LeufsTer18 | p.S639Lfs*18 | Q13330 | protein_coding | TCGA-HU-A4H3-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | ts-1 | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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