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Gene: MORC4 |
Gene summary for MORC4 |
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Gene information | Species | Human | Gene symbol | MORC4 | Gene ID | 79710 |
Gene name | MORC family CW-type zinc finger 4 | |
Gene Alias | ZCW4 | |
Cytomap | Xq22.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | B4DTP6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79710 | MORC4 | LZE24T | Human | Esophagus | ESCC | 2.11e-06 | 3.40e-01 | 0.0596 |
79710 | MORC4 | P1T-E | Human | Esophagus | ESCC | 1.13e-06 | 3.31e-01 | 0.0875 |
79710 | MORC4 | P2T-E | Human | Esophagus | ESCC | 2.08e-20 | 5.05e-01 | 0.1177 |
79710 | MORC4 | P4T-E | Human | Esophagus | ESCC | 2.81e-18 | 4.72e-01 | 0.1323 |
79710 | MORC4 | P5T-E | Human | Esophagus | ESCC | 7.16e-19 | 3.05e-01 | 0.1327 |
79710 | MORC4 | P8T-E | Human | Esophagus | ESCC | 5.18e-12 | 2.44e-01 | 0.0889 |
79710 | MORC4 | P10T-E | Human | Esophagus | ESCC | 6.53e-07 | 1.93e-01 | 0.116 |
79710 | MORC4 | P11T-E | Human | Esophagus | ESCC | 1.64e-07 | 2.71e-01 | 0.1426 |
79710 | MORC4 | P12T-E | Human | Esophagus | ESCC | 1.40e-06 | 1.51e-01 | 0.1122 |
79710 | MORC4 | P15T-E | Human | Esophagus | ESCC | 3.96e-02 | 1.12e-01 | 0.1149 |
79710 | MORC4 | P16T-E | Human | Esophagus | ESCC | 2.27e-10 | 2.17e-01 | 0.1153 |
79710 | MORC4 | P17T-E | Human | Esophagus | ESCC | 2.86e-02 | 1.55e-01 | 0.1278 |
79710 | MORC4 | P21T-E | Human | Esophagus | ESCC | 1.21e-02 | 5.23e-02 | 0.1617 |
79710 | MORC4 | P22T-E | Human | Esophagus | ESCC | 1.91e-10 | 2.25e-01 | 0.1236 |
79710 | MORC4 | P23T-E | Human | Esophagus | ESCC | 1.98e-07 | 2.46e-01 | 0.108 |
79710 | MORC4 | P24T-E | Human | Esophagus | ESCC | 1.54e-03 | 1.05e-01 | 0.1287 |
79710 | MORC4 | P26T-E | Human | Esophagus | ESCC | 1.06e-15 | 3.04e-01 | 0.1276 |
79710 | MORC4 | P27T-E | Human | Esophagus | ESCC | 3.62e-08 | 1.37e-01 | 0.1055 |
79710 | MORC4 | P28T-E | Human | Esophagus | ESCC | 3.56e-06 | 2.41e-01 | 0.1149 |
79710 | MORC4 | P31T-E | Human | Esophagus | ESCC | 4.65e-07 | 7.08e-02 | 0.1251 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MORC4 | SNV | Missense_Mutation | c.839N>A | p.Arg280His | p.R280H | Q8TE76 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-D1-A177-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
MORC4 | SNV | Missense_Mutation | novel | c.328N>T | p.Val110Leu | p.V110L | Q8TE76 | protein_coding | tolerated(0.15) | benign(0.145) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MORC4 | SNV | Missense_Mutation | novel | c.349N>T | p.Pro117Ser | p.P117S | Q8TE76 | protein_coding | tolerated(0.23) | probably_damaging(0.966) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
MORC4 | SNV | Missense_Mutation | rs370972961 | c.299N>A | p.Arg100Gln | p.R100Q | Q8TE76 | protein_coding | deleterious(0.02) | probably_damaging(0.971) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
MORC4 | SNV | Missense_Mutation | rs779948361 | c.1684N>G | p.Ser562Gly | p.S562G | Q8TE76 | protein_coding | tolerated(0.09) | benign(0.073) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
MORC4 | SNV | Missense_Mutation | novel | c.1479N>T | p.Lys493Asn | p.K493N | Q8TE76 | protein_coding | deleterious(0.01) | possibly_damaging(0.777) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MORC4 | SNV | Missense_Mutation | novel | c.423N>T | p.Lys141Asn | p.K141N | Q8TE76 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MORC4 | SNV | Missense_Mutation | rs370972961 | c.299G>A | p.Arg100Gln | p.R100Q | Q8TE76 | protein_coding | deleterious(0.02) | probably_damaging(0.971) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MORC4 | SNV | Missense_Mutation | novel | c.2714C>A | p.Ser905Tyr | p.S905Y | Q8TE76 | protein_coding | deleterious(0.05) | probably_damaging(0.962) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MORC4 | SNV | Missense_Mutation | novel | c.808G>A | p.Ala270Thr | p.A270T | Q8TE76 | protein_coding | deleterious(0.03) | probably_damaging(0.993) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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