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Gene: MEI1 |
Gene summary for MEI1 |
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Gene information | Species | Human | Gene symbol | MEI1 | Gene ID | 150365 |
Gene name | meiotic double-stranded break formation protein 1 | |
Gene Alias | HYDM3 | |
Cytomap | 22q13.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q4G0I1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
150365 | MEI1 | CCI_3 | Human | Cervix | CC | 6.87e-34 | 1.54e+00 | 0.516 |
150365 | MEI1 | CCII_1 | Human | Cervix | CC | 1.61e-12 | 5.15e-01 | 0.3249 |
150365 | MEI1 | GSM5353218_PA_PB1B_Pool_1_2_S74_L003 | Human | Prostate | Tumor | 8.74e-03 | 5.76e-01 | 0.1479 |
150365 | MEI1 | GSM5353220_PA_PB1B_Pool_3_S51_L002 | Human | Prostate | Tumor | 1.61e-04 | 6.39e-01 | 0.1531 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00482851 | Cervix | CC | organelle fission | 78/2311 | 488/18723 | 9.70e-03 | 4.79e-02 | 78 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MEI1 | SNV | Missense_Mutation | c.3001G>A | p.Ala1001Thr | p.A1001T | Q5TIA1 | protein_coding | tolerated(0.37) | benign(0.001) | TCGA-CC-A7IJ-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MEI1 | SNV | Missense_Mutation | novel | c.3220N>A | p.Ala1074Thr | p.A1074T | Q5TIA1 | protein_coding | tolerated(0.15) | benign(0.439) | TCGA-DD-AACG-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
MEI1 | SNV | Missense_Mutation | novel | c.442N>T | p.Met148Leu | p.M148L | Q5TIA1 | protein_coding | tolerated(0.1) | benign(0.022) | TCGA-DD-AAE9-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MEI1 | SNV | Missense_Mutation | c.236T>A | p.Leu79Gln | p.L79Q | Q5TIA1 | protein_coding | tolerated(0.07) | benign(0.347) | TCGA-ED-A459-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Ancillary | alvesin | CR | |
MEI1 | SNV | Missense_Mutation | rs756386772 | c.1440N>T | p.Arg480Ser | p.R480S | Q5TIA1 | protein_coding | deleterious(0.03) | benign(0.014) | TCGA-44-8117-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MEI1 | SNV | Missense_Mutation | c.793N>A | p.Gly265Arg | p.G265R | Q5TIA1 | protein_coding | tolerated(0.55) | benign(0.031) | TCGA-44-8120-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MEI1 | SNV | Missense_Mutation | c.73N>A | p.Glu25Lys | p.E25K | Q5TIA1 | protein_coding | tolerated(0.11) | benign(0.003) | TCGA-50-5946-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
MEI1 | SNV | Missense_Mutation | c.1351N>G | p.Pro451Ala | p.P451A | Q5TIA1 | protein_coding | deleterious(0.02) | benign(0.254) | TCGA-55-6972-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MEI1 | SNV | Missense_Mutation | c.1916C>T | p.Ser639Leu | p.S639L | Q5TIA1 | protein_coding | tolerated(0.12) | benign(0.007) | TCGA-55-8208-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
MEI1 | SNV | Missense_Mutation | novel | c.1713N>C | p.Leu571Phe | p.L571F | Q5TIA1 | protein_coding | deleterious(0.01) | possibly_damaging(0.491) | TCGA-62-8399-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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