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Gene: MARS |
Gene summary for MARS |
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Gene information | Species | Human | Gene symbol | MARS | Gene ID | 84174 |
Gene name | Src like adaptor 2 | |
Gene Alias | C20orf156 | |
Cytomap | 20q11.23 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9H6Q3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84174 | MARS | LZE4T | Human | Esophagus | ESCC | 2.66e-06 | 2.09e-01 | 0.0811 |
84174 | MARS | LZE7T | Human | Esophagus | ESCC | 1.73e-13 | 6.35e-01 | 0.0667 |
84174 | MARS | LZE8T | Human | Esophagus | ESCC | 6.35e-03 | 1.11e-01 | 0.067 |
84174 | MARS | LZE20T | Human | Esophagus | ESCC | 5.56e-07 | 2.62e-01 | 0.0662 |
84174 | MARS | LZE22T | Human | Esophagus | ESCC | 4.66e-08 | 3.76e-01 | 0.068 |
84174 | MARS | LZE24T | Human | Esophagus | ESCC | 3.21e-14 | 4.98e-01 | 0.0596 |
84174 | MARS | LZE21T | Human | Esophagus | ESCC | 1.70e-05 | 3.39e-01 | 0.0655 |
84174 | MARS | P1T-E | Human | Esophagus | ESCC | 1.08e-05 | 5.67e-01 | 0.0875 |
84174 | MARS | P2T-E | Human | Esophagus | ESCC | 1.55e-41 | 9.38e-01 | 0.1177 |
84174 | MARS | P4T-E | Human | Esophagus | ESCC | 6.67e-19 | 5.69e-01 | 0.1323 |
84174 | MARS | P5T-E | Human | Esophagus | ESCC | 2.37e-20 | 4.43e-01 | 0.1327 |
84174 | MARS | P8T-E | Human | Esophagus | ESCC | 5.66e-20 | 4.03e-01 | 0.0889 |
84174 | MARS | P9T-E | Human | Esophagus | ESCC | 1.61e-09 | 2.01e-01 | 0.1131 |
84174 | MARS | P10T-E | Human | Esophagus | ESCC | 3.40e-23 | 5.15e-01 | 0.116 |
84174 | MARS | P11T-E | Human | Esophagus | ESCC | 2.36e-16 | 7.47e-01 | 0.1426 |
84174 | MARS | P12T-E | Human | Esophagus | ESCC | 7.37e-35 | 7.64e-01 | 0.1122 |
84174 | MARS | P15T-E | Human | Esophagus | ESCC | 1.31e-19 | 4.85e-01 | 0.1149 |
84174 | MARS | P16T-E | Human | Esophagus | ESCC | 5.93e-28 | 5.77e-01 | 0.1153 |
84174 | MARS | P17T-E | Human | Esophagus | ESCC | 1.62e-10 | 4.71e-01 | 0.1278 |
84174 | MARS | P19T-E | Human | Esophagus | ESCC | 2.42e-07 | 7.45e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:00063992 | Esophagus | ESCC | tRNA metabolic process | 122/8552 | 179/18723 | 9.03e-10 | 2.19e-08 | 122 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MARS | SNV | Missense_Mutation | c.1483N>G | p.Ile495Val | p.I495V | P56192 | protein_coding | tolerated(0.07) | probably_damaging(0.946) | TCGA-95-8039-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
MARS | SNV | Missense_Mutation | rs745605073 | c.2264N>C | p.Met755Thr | p.M755T | P56192 | protein_coding | deleterious(0) | benign(0.065) | TCGA-21-1080-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MARS | SNV | Missense_Mutation | novel | c.2111N>G | p.Ala704Gly | p.A704G | P56192 | protein_coding | tolerated(1) | benign(0.015) | TCGA-52-7622-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MARS | SNV | Missense_Mutation | c.769N>A | p.Val257Met | p.V257M | P56192 | protein_coding | deleterious(0) | possibly_damaging(0.701) | TCGA-56-6546-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MARS | SNV | Missense_Mutation | novel | c.2621N>G | p.Ala874Gly | p.A874G | P56192 | protein_coding | tolerated(0.18) | benign(0.189) | TCGA-60-2715-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | docetaxel | PD |
MARS | SNV | Missense_Mutation | novel | c.542N>T | p.Pro181Leu | p.P181L | P56192 | protein_coding | tolerated(0.3) | benign(0.021) | TCGA-94-8491-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | unknown | PD |
MARS | insertion | Frame_Shift_Ins | novel | c.451_452insC | p.Leu152ProfsTer13 | p.L152Pfs*13 | P56192 | protein_coding | TCGA-NJ-A4YQ-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MARS | SNV | Missense_Mutation | novel | c.232G>A | p.Asp78Asn | p.D78N | P56192 | protein_coding | tolerated(0.55) | benign(0.007) | TCGA-CR-7374-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MARS | SNV | Missense_Mutation | novel | c.2263N>G | p.Met755Val | p.M755V | P56192 | protein_coding | tolerated(0.06) | benign(0.009) | TCGA-CR-7399-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MARS | SNV | Missense_Mutation | novel | c.1451N>G | p.Ser484Cys | p.S484C | P56192 | protein_coding | deleterious(0.01) | probably_damaging(0.984) | TCGA-CX-7086-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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