|
Gene: MAP3K4 |
Gene summary for MAP3K4 |
Gene summary. |
Gene information | Species | Human | Gene symbol | MAP3K4 | Gene ID | 4216 |
Gene name | mitogen-activated protein kinase kinase kinase 4 | |
Gene Alias | MAPKKK4 | |
Cytomap | 6q26 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9Y6R4 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4216 | MAP3K4 | CCI_1 | Human | Cervix | CC | 2.43e-09 | 9.63e-01 | 0.528 |
4216 | MAP3K4 | CCI_3 | Human | Cervix | CC | 6.83e-04 | 5.37e-01 | 0.516 |
4216 | MAP3K4 | LZE4T | Human | Esophagus | ESCC | 2.69e-14 | 3.73e-01 | 0.0811 |
4216 | MAP3K4 | LZE7T | Human | Esophagus | ESCC | 6.51e-09 | 3.09e-01 | 0.0667 |
4216 | MAP3K4 | LZE8T | Human | Esophagus | ESCC | 1.80e-02 | 9.09e-02 | 0.067 |
4216 | MAP3K4 | LZE20T | Human | Esophagus | ESCC | 3.49e-04 | 1.33e-01 | 0.0662 |
4216 | MAP3K4 | LZE22D1 | Human | Esophagus | HGIN | 1.32e-03 | 1.40e-01 | 0.0595 |
4216 | MAP3K4 | LZE24T | Human | Esophagus | ESCC | 1.91e-07 | 2.37e-01 | 0.0596 |
4216 | MAP3K4 | LZE21T | Human | Esophagus | ESCC | 2.62e-05 | 2.35e-01 | 0.0655 |
4216 | MAP3K4 | P1T-E | Human | Esophagus | ESCC | 7.91e-13 | 4.05e-01 | 0.0875 |
4216 | MAP3K4 | P2T-E | Human | Esophagus | ESCC | 1.07e-16 | 4.23e-01 | 0.1177 |
4216 | MAP3K4 | P4T-E | Human | Esophagus | ESCC | 1.53e-27 | 4.17e-01 | 0.1323 |
4216 | MAP3K4 | P5T-E | Human | Esophagus | ESCC | 1.51e-25 | 4.66e-01 | 0.1327 |
4216 | MAP3K4 | P8T-E | Human | Esophagus | ESCC | 8.48e-25 | 3.64e-01 | 0.0889 |
4216 | MAP3K4 | P9T-E | Human | Esophagus | ESCC | 2.48e-06 | 1.34e-01 | 0.1131 |
4216 | MAP3K4 | P10T-E | Human | Esophagus | ESCC | 1.73e-27 | 3.25e-01 | 0.116 |
4216 | MAP3K4 | P11T-E | Human | Esophagus | ESCC | 5.16e-14 | 4.85e-01 | 0.1426 |
4216 | MAP3K4 | P12T-E | Human | Esophagus | ESCC | 5.67e-18 | 3.62e-01 | 0.1122 |
4216 | MAP3K4 | P15T-E | Human | Esophagus | ESCC | 9.37e-27 | 4.84e-01 | 0.1149 |
4216 | MAP3K4 | P16T-E | Human | Esophagus | ESCC | 2.19e-23 | 3.68e-01 | 0.1153 |
Page: 1 2 3 4 5 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003367410 | Cervix | CC | positive regulation of kinase activity | 101/2311 | 467/18723 | 8.66e-09 | 7.22e-07 | 101 |
GO:00458608 | Cervix | CC | positive regulation of protein kinase activity | 85/2311 | 386/18723 | 5.61e-08 | 3.29e-06 | 85 |
GO:00018908 | Cervix | CC | placenta development | 40/2311 | 144/18723 | 4.59e-07 | 1.77e-05 | 40 |
GO:00310988 | Cervix | CC | stress-activated protein kinase signaling cascade | 58/2311 | 247/18723 | 8.02e-07 | 2.89e-05 | 58 |
GO:00614588 | Cervix | CC | reproductive system development | 87/2311 | 427/18723 | 1.37e-06 | 4.55e-05 | 87 |
GO:00486088 | Cervix | CC | reproductive structure development | 86/2311 | 424/18723 | 1.90e-06 | 5.97e-05 | 86 |
GO:00719007 | Cervix | CC | regulation of protein serine/threonine kinase activity | 75/2311 | 359/18723 | 2.76e-06 | 8.02e-05 | 75 |
GO:00514038 | Cervix | CC | stress-activated MAPK cascade | 55/2311 | 239/18723 | 2.96e-06 | 8.31e-05 | 55 |
GO:00703027 | Cervix | CC | regulation of stress-activated protein kinase signaling cascade | 46/2311 | 195/18723 | 9.35e-06 | 2.11e-04 | 46 |
GO:00719025 | Cervix | CC | positive regulation of protein serine/threonine kinase activity | 46/2311 | 200/18723 | 1.87e-05 | 3.47e-04 | 46 |
GO:00434104 | Cervix | CC | positive regulation of MAPK cascade | 90/2311 | 480/18723 | 2.92e-05 | 4.83e-04 | 90 |
GO:00328727 | Cervix | CC | regulation of stress-activated MAPK cascade | 44/2311 | 192/18723 | 3.09e-05 | 5.10e-04 | 44 |
GO:00093149 | Cervix | CC | response to radiation | 86/2311 | 456/18723 | 3.50e-05 | 5.63e-04 | 86 |
GO:00380664 | Cervix | CC | p38MAPK cascade | 17/2311 | 55/18723 | 2.25e-04 | 2.54e-03 | 17 |
GO:00094112 | Cervix | CC | response to UV | 33/2311 | 149/18723 | 5.51e-04 | 5.29e-03 | 33 |
GO:00510528 | Cervix | CC | regulation of DNA metabolic process | 65/2311 | 359/18723 | 9.25e-04 | 7.84e-03 | 65 |
GO:19007442 | Cervix | CC | regulation of p38MAPK cascade | 14/2311 | 47/18723 | 1.18e-03 | 9.56e-03 | 14 |
GO:00703043 | Cervix | CC | positive regulation of stress-activated protein kinase signaling cascade | 27/2311 | 128/18723 | 3.49e-03 | 2.26e-02 | 27 |
GO:20002789 | Cervix | CC | regulation of DNA biosynthetic process | 23/2311 | 106/18723 | 4.65e-03 | 2.81e-02 | 23 |
GO:00519738 | Cervix | CC | positive regulation of telomerase activity | 10/2311 | 34/18723 | 6.40e-03 | 3.58e-02 | 10 |
Page: 1 2 3 4 5 6 7 8 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0491212 | Cervix | CC | GnRH signaling pathway | 26/1267 | 93/8465 | 8.72e-04 | 3.87e-03 | 2.29e-03 | 26 |
hsa040109 | Cervix | CC | MAPK signaling pathway | 62/1267 | 302/8465 | 4.89e-03 | 1.67e-02 | 9.86e-03 | 62 |
hsa0491213 | Cervix | CC | GnRH signaling pathway | 26/1267 | 93/8465 | 8.72e-04 | 3.87e-03 | 2.29e-03 | 26 |
hsa0401012 | Cervix | CC | MAPK signaling pathway | 62/1267 | 302/8465 | 4.89e-03 | 1.67e-02 | 9.86e-03 | 62 |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAP3K4 | SNV | Missense_Mutation | novel | c.4441N>T | p.Asp1481Tyr | p.D1481Y | Q9Y6R4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MAP3K4 | SNV | Missense_Mutation | novel | c.3890N>C | p.Ile1297Thr | p.I1297T | Q9Y6R4 | protein_coding | deleterious(0.01) | benign(0.075) | TCGA-A5-A2K7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD |
MAP3K4 | SNV | Missense_Mutation | novel | c.740G>T | p.Arg247Ile | p.R247I | Q9Y6R4 | protein_coding | deleterious(0) | possibly_damaging(0.613) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
MAP3K4 | SNV | Missense_Mutation | novel | c.213C>A | p.Phe71Leu | p.F71L | Q9Y6R4 | protein_coding | tolerated_low_confidence(0.66) | benign(0) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MAP3K4 | SNV | Missense_Mutation | novel | c.776G>A | p.Arg259Gln | p.R259Q | Q9Y6R4 | protein_coding | tolerated(0.42) | benign(0.019) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MAP3K4 | SNV | Missense_Mutation | c.4576N>A | p.Ala1526Thr | p.A1526T | Q9Y6R4 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MAP3K4 | SNV | Missense_Mutation | c.439N>G | p.Arg147Gly | p.R147G | Q9Y6R4 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MAP3K4 | SNV | Missense_Mutation | c.670N>C | p.Lys224Gln | p.K224Q | Q9Y6R4 | protein_coding | tolerated(0.14) | probably_damaging(0.997) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MAP3K4 | SNV | Missense_Mutation | c.1211N>C | p.Asn404Thr | p.N404T | Q9Y6R4 | protein_coding | tolerated(0.11) | probably_damaging(0.995) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MAP3K4 | SNV | Missense_Mutation | rs775727719 | c.863N>A | p.Arg288His | p.R288H | Q9Y6R4 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |